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Physician-scientists at IU School of Medicine conduct ground-breaking research studies to understand diabetes.

Diabetes Research Studies

Diabetes mellitus is a group of conditions that impact how your body processes blood sugar, or glucose — your body’s primary source of energy for muscles, tissues, and especially the brain. While the underlying causes differ between types of diabetes, they all result in elevated blood sugar levels. Over time, high blood sugar can lead to serious health complications if not managed properly.

Investigators

172-Gromski, Mark

Mark A. Gromski, MD

Associate Professor of Medicine

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5034-Vuppalanchi, Raj

Raj Vuppalanchi, M.D.

Professor of Medicine

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Open Research Studies for Diabetes

A Prospective, Randomized, Double-Blind, Sham-Controlled, Multi-Center Pivotal Study to Evaluate the Efficacy and Safety of Duodenal Mucosal Resurfacing Using the Revita System in Subjects With Type 2 Diabetes on Insulin Therapy

Enrolling: No

Principle Investigators:  Mark Gromski, MD, Raj Vuppalanchi, MD

Primary Outcome Measurement: Percentage of subjects who achieve a HbA1c ≤ 7.0% at Week 24 without the need for insulin at Week 24, DMR vs Sham.

View the study on clinicaltrials.gov

Closed Diabetes Studies

Enrolling: No

Primary Objective: 

To prospectively assemble a cohort of subjects ≥50 and ≤85 years of age with New-onset Hyperglycemia and Diabetes (NOD), called the NOD Cohort, in order to:

  1. Estimate the probability of pancreatic ductal adenocarcinoma (PDAC) in the NOD Cohort
  2. Establish a biobank of clinically annotated biospecimens including a reference set of biospecimens from pre-symptomatic PDAC and control new-onset Hyperglycemia and type 2 Diabetes Mellitus (DM) subjects
  3. Facilitate validation of emerging tests for identifying NOD subjects at high risk for having PDAC using the reference set

View this study on clinicaltrials.gov