Eosinophilic esophagitis (EoE) is a chronic, allergic inflammatory disease of the esophagus. EoE affects children and adults. It occurs when a type of white blood cell, the eosinophil, accumulates in the esophagus. The elevated number of eosinophils causes injury and inflammation to the esophagus, eventually leading to scar tissues. Adults with EoE usually present with difficulty swallowing. Many patient have other allergic diseases, such as seasonal allergies, asthma, allergic reactions to foods and environment.
Investigators
Open Research Studies for Eosinophilic Eosophagitis
Changes in Esophageal Distensibility in Patients with Esophageal Eosinophilia with Proton Pump Inhibitors in Patients with Eosinophilic Esophagitis: A Pilot Study
Enrolling: Yes
Principle Investigator: Akira Saito, MD
Duration: 4 months
Primary Outcomes Measured: To measure the changes in esophageal distensibility before and after treatment with PPI, topical steroids, or elimination diet in patients with esophageal eosinophilia.
Secondary Outcomes Measured: To correlate the changes in esophageal distensibility with dysphagia before and after treatment with PPI, topical steroids, or elimination diet in patients with esophageal eosinophilia.
Interested in this study? Please contact the coordinator below:
Maureen Schilling
Indiana University Eosinophilic Gastrointestinal Disorder Registry
Enrolling: Yes
Principle Investigator: Akira Saito, MD
Primary Outcomes Measured: Build a patient registry for eosinophilic gastrointestinal disorders (EGIDs), including eosinophilic esophagitis (EoE), gastritis (EG), and enteritis. These conditions involve inflammation triggered by elevated immune cells called eosinophils and can affect the esophagus, stomach, or small intestine.
Secondary Outcomes Measured: Help our team monitor care and better understand the nature and impact of these disorders.
Interested in this study? Please contact the coordinator below:
Maureen Schilling
Celiac Disease and EoE: A Comparative Study
Principle Investigator: Akira Saito, MD
Primary Outcomes Measured: To examine outcomes (clinical, endoscopic, histologic) for patients with celiac disease and EoE.
Secondary Outcomes Measured: To examine nutritional outcomes and clinical care in these patients.
Tertiary/Exploratory/Correlative Objectives: To assess pathologic severity of disease and associated conditions in these patients and other endoscopic findings.
Interested in this study? Please contact the coordinator below:
Maureen Schilling