Precision PULmonary Medicine, P-PULM, is a multidisciplinary research initiative that integrates advanced biomedical technologies — such as multi-omics, genomics, transcriptomics, proteomics, metabolomics, microbiomics and exposomics — with clinical and social data to improve the understanding, diagnosis and treatment of lung and respiratory diseases. The goal is to tailor interventions to individual patients based on their unique molecular, genetic, environmental and lifestyle profiles.
P-PULM is housed within the Division of Pulmonary, Critical Care and Sleep Medicine in the Department of Medicine at Indiana University School of Medicine. The program provides a robust framework for applying omics technologies to improve the diagnosis and management of lung and respiratory diseases, with a focus on identifying molecular characteristics that enable more precise prevention, diagnosis and treatment.
Members of P-PULM have access to cutting-edge technologies led by a dedicated analytics team with expertise in statistics, biostatistics, bioinformatics and functional genomics. The program hosts a fully equipped computational lab featuring high-performance Mac, PC and Linux workstations, servers and parallel computing resources. All necessary software for pulmonary research and access to research databases are available.
Innovative Multidisciplinary Research Design
Key research goals include:
- Understanding the biological and environmental exposure basis of individual variations in pulmonary and respiratory diseases presentation, treatment response and outcomes.
- Identifying clinical practices that exacerbate pulmonary/respiratory health disparities and advance health and disease for all.
- Share the latest findings from basic science and translational research that will inform the development of precision medicine approaches to the treatment or prevention of pulmonary and respiratory diseases.
