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The Systems Biology and Multi-Omics Core

The Systems Biology and Multi-Omics Core provides comprehensive support for musculoskeletal research at the Indiana Center for Musculoskeletal Health (ICMH) by enabling genomic and metabolomic studies tailored to the unique challenges of skeletal muscle, bone and tendon tissues. 

As an integrated extension of the Center for Medical Genomics, the Center for Computational Biology and Bioinformatics and a newly established virtual metabolomics service, the Systems Biology and Multi-Omics Core coordinates study design, assay selection, data generation, analysis and dissemination. It also promotes novel technology development and training in omics-based approaches. 

By combining investigator-generated and publicly available datasets, the core drives new mechanistic insights in musculoskeletal biology through cutting-edge computational and bioinformatics infrastructure at Indiana University School of Medicine. This core will not only provide essential services at subsidized rates, as well as serving as an educational and collaborative hub, empowering musculoskeletal health investigators to generate transformative discoveries with unprecedented molecular resolution.

Services

instrument for genomic sequencing

The Systems Biology and Multi-Omics Core offers the following services:

  • Bioinformatics consulting and experimental design
  • DNA/RNA-seq analysis
  • Single cell analysis
  • Metabolomics analysis
  • Epigenetics analysis

Price

$120/hour with 50% discount of preliminary results generation for future grant application 

Leadership

196-Liu, Yunlong

Yunlong Liu, PhD

Professor of Medical & Molecular Genetics

Core Director

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26797-O'Connell, Thomas

Thomas M. O'Connell, PhD

Associate Professor of Otolaryngology-Head & Neck Surgery

Core Co-Director

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63227-Peng, Gang

Gang Peng, PhD

Assistant Professor of Medical & Molecular Genetics

Director of Bioinformatics

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Acknowledgment Policy

In all cases, the core requests that the following statement be placed in an acknowledgements section of any published work that utilizes core facilities: 

“Bioinformatics analysis for this study was supported by the Bioinformatics Core at the Indiana Center for Musculoskeletal Health. We thank the core for assistance with data processing, analysis and interpretation."

 

Publications

So, J., Strobel, O., Wann, J., Kim, K., Paul, A., Acri, D.J., Dabin, L.C., Kim, J., Peng, G. and Roh, H.C., 2025. Robust single-nucleus RNA sequencing reveals depot-specific cell population dynamics in adipose tissue remodeling during obesity. Elife, 13, p.RP97981. 

Peng, G., Deosthale, P., Pianeta, R., Messersmith, H.M. and Plotkin, L.I., 2024. Sex dimorphic response to osteocyte miR21 deletion in murine calvaria bone as determined by RNAseq analysis. JBMR plus, 8(6), p.ziae054. 

Shimonty, A., Pin, F., Prideaux, M., Peng, G., Huot, J., Kim, H., Rosen, C.J., Spiegelman, B.M. and Bonewald, L.F., 2024. Deletion of FNDC5/Irisin modifies murine osteocyte function in a sex-specific manner. Elife, 12, p.RP92263. 

Prideaux M, Smargiassi A, Peng G, Brotto M, Robling AG, Bonewald LF. 2023. L-BAIBA Synergizes with Sub-Optimal Mechanical Loading to Promote New Bone Formation. JBMR Plus. 7(6):e10746.