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Neuromuscular Function Core

Capturing the functional impact of intervention at the muscle level

The Neuromuscular Function Core provides reliable, high-quality, standardized evaluation tools and expertise for the assessment of muscle function in small animals. The core focuses on changes in contractile properties that emerge from genetic manipulations, pharmacologic treatments, surgical interventions, dietary modifications, trauma, exercise/loading programs, induced disease (e.g., cancer and diabetes) or other environmental modifications. The core provides full service muscle testing ranging from experimental design consultation, fee-for-service measures of in vivo and ex vivo muscle contraction, access to instrumentation and equipment, training to investigators and their staff, standard operating procedures for all methodology, maintenance and calibration of all equipment, and expertise and advice for interpretation of results generated through the core. With the understanding that reliable skeletal muscle contractile measures require extensive experience by the investigator, a particular focus of the core is to perform the contractile measures on a fee-for-service basis. 

Services

equipment and computers in the neuromuscular function coreThe Neuromuscular Function Core offers the following services: 

  • Standardized, high-quality evaluation tools for assessing muscle function in small animals 

  • Experimental design consultation for neuromuscular studies 

  • Fee-for-service in vivo and ex vivo muscle contraction assessments 

  • Evaluation of contractile changes resulting from: 

    • Genetic manipulation 

    • Pharmacologic treatment 

    • Surgical intervention 

    • Dietary modification 

    • Trauma or injury models 

    • Exercise/loading protocols 

    • Disease induction (e.g., cancer, diabetes) 

    • Environmental modifications 

  • Access to instrumentation and equipment for neuromuscular function testing 

  • Training for investigators and staff on the use of equipment and techniques 

  • Provision of standard operating procedures (SOPs) for all methodologies 

  • Maintenance and calibration of neuromuscular testing equipment 

  • Interpretation support and expertise for muscle function data 

  • Specialized performance of muscle contractile testing by experienced core personnel (recommended due to technical complexity) 

Schedule in iLab

Leadership

15321-Fischer, Kathryn

Kathryn D. Fischer, PhD

Director, Behavioral Phenotyping Core

 Core Director

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47500-Brault, Jeff

Jeff Brault, PhD

Associate Professor of Anatomy, Cell Biology & Physiology

Core Co-Director

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43332-Huot, Joshua

Joshua R. Huot, PhD

Assistant Professor of Anatomy, Cell Biology & Physiology

 Core Co-Director

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David L. Waning, PhD

Associate Research Professor of Orthopaedic Surgery

Core Co-Director

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Acknowledgment Policy

In all cases, the core requests that the following statement be placed in an acknowledgements section of any published work that utilizes core facilities: 

“This work was supported by the Neuromuscular Function Core of the Indiana Center for Musculoskeletal Health (ICMH).”