196-Liu, Yunlong

Yunlong Liu, PhD

Director, Center for Computational Biology & Bioinformatics

Director, Center for Medical Genomics

Chancellor’s Professor, IU Indianapolis

T.K. Li Professor of Medical Research

Professor of Medical & Molecular Genetics

Professor of Biostatistics & Health Data Science

Adjunct Professor of Medicine

Email
yunliu@iu.edu
Phone
317-278-9222
Address
HS 5001
MMGE
IN
Indianapolis, IN
PubMed:

Bio

The Liu Laboratory (Laboratory for Computational Genomics) uses systems biology approaches to understand regulatory mechanisms of gene expression, including transcriptional regulation, post-transcriptional regulation, and epigenetic regulation. This area involves several interdisciplinary components, including functional genomics, genetics, computational and statistical modeling, computer science/engineering, and data management.

Liu Lab Website

Key Publications

Li R, Reiter JL, Chen AB, Chen SX, Foroud T, Edenberg HJ, Lai D, Liu Y. RNA alternative splicing impacts the risk for alcohol use disorder. Mol Psychiatry. 2023 May 23. doi: 10.1038/s41380-023-02111-1. Epub ahead of print. PMID: 37217680.

Chen SX, Simpson E, Reiter JL, Liu Y. Bioinformatics detection of modulators controlling splicing factor-dependent intron retention in the human brain. Hum Mutat. 2022 Nov;43(11):1629-1641. doi: 10.1002/humu.24379. Epub 2022 May 10. PMID: 35391504; PMCID: PMC9537345.

Dong C, Reiter JL, Dong E, Wang Y, Lee KP, Lu X, Liu Y. Intron-Retention Neoantigen Load Predicts Favorable Prognosis in Pancreatic Cancer. JCO Clin Cancer Inform. 2022 Feb;6:e2100124. doi: 10.1200/CCI.21.00124. PMID: 35148169; PMCID: PMC8846286.

Rao X, Thapa KS, Chen AB, Lin H, Gao H, Reiter JL, Hargreaves KA, Ipe J, Lai D, Xuei X, Wang Y, Gu H, Kapoor M, Farris SP, Tischfield J, Foroud T, Goate AM, Skaar TC, Mayfield RD, Edenberg HJ, Liu Y. Allele-specific expression and high- throughput reporter assay reveal functional genetic variants associated with alcohol use disorders. Mol Psychiatry. 2021 Apr;26(4):1142-1151. doi: 10.1038/s41380-019-0508-z. Epub 2019 Sep 2. PMID: 31477794; PMCID: PMC7050407.

Dong C, Cesarano A, Bombaci G, Reiter JL, Yu CY, Wang Y, Jiang Z, Zaid MA, Huang K, Lu X, Walker BA, Perna F, Liu Y. Intron retention-induced neoantigen load correlates with unfavorable prognosis in multiple myeloma. Oncogene. 2021 Oct;40(42):6130-6138. doi: 10.1038/s41388-021-02005-y. Epub 2021 Sep 9. PMID: 34504297; PMCID: PMC8426332.

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