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Research

The Division of Pediatric Pulmonology, Allergy and Sleep Medicine in the Department of Pediatrics at Indiana University School of Medicine conducts basic, translational and clinical research. Specific areas of study include cystic fibrosis, asthma, bronchopulmonary dysplasia, primary ciliary dyskinesia, specialized physiologic testing, allergic diseases and sleep disorders.

The division has a history of participating in investigator-initiated studies as well as drug trials and is a part of the Cystic Fibrosis Foundation Therapeutic Development Network, the Food Allergy Research and Education Network, and the Pediatric Behavioral Sleep Research Network. The division has been awarded funding from the NIH, the Cystic Fibrosis Foundation, the American Lung Association, the American Academy of Allergy, Asthma and Immunology, and the Food Allergy Research and Education Network.

Get Research Updates

Research faculty throughout IU School of Medicine’s academic departments post updates about their work to the research updates blog. Stay up-to-date about medical research in pediatrics.

Leadership with Research Expertise

Leadership with Research Expertise

In January 2019, James F. Chmiel, MD, joined the faculty at Riley Hospital for Children and Indiana University School of Medicine as the Division Chief for Pediatric Pulmonology, Allergy, and Sleep Medicine. Dr. Chmiel brings to an exceptional translational research expertise with an outstanding educational talent to develop new generation of pediatric pulmonologists.

Dr. Chmiel was Associate Director, LeRoy W. Matthews Cystic Fibrosis Center, Division of Pediatric Pulmonology, Rainbow Babies and Children’s Hospital in Cleveland, Ohio, and Director of the Pediatric Pulmonology Fellowship at Case Western Reserve University (CWRU) for 14 years. Early in his career, Dr. Chmiel primarily focused in basic science and translational research to study the airway inflammatory response in a mouse model. He then transitioned to a clinical research career to better understand the inflammatory response of the lung, particularly as it relates to asthma and CF and the impact of anti-inflammatory therapeutics upon this response. Dr. Chmiel is particularly interested in studying the counter-regulatory mechanisms responsible for modulating the airway inflammatory response.

Dr. Chmiel participates in both independent and multi-center clinical trials and has been the lead PI on several multi-center studies sponsored by the Cystic Fibrosis Foundation’s Therapeutic Development Network (TDN). With more than fourteen years of experience mentoring various levels of academic trainees, Dr. Chmiel has mentored dozens of assistant or associate level professors, several of which have received NIH loan-repayment, early investigator Cystic Fibrosis Foundation or K awards. 

Herman B Wells Center for Pediatric Research

Herman B Wells Center for Pediatric Research

The Pulmonary Inflammation/Asthma and Allergic Diseases Research Group within the Wells Center for Pediatric Research studies the initiation, pathogenesis and progression of these diseases to identify better ways to treat or prevent allergic symptoms. Research spans many areas–from examining the regulation of genes important for the development of T cells involved in allergic inflammation and the biology of cytokines and other factors that promote allergic disease to examining lung development and function and how changes contribute to lung reactivity to allergens.

Pediatric Translational Research Center

Pediatric Translational Research Center

The Pediatric Translational Research Center is the flagship pediatric research facility located in Riley Hospital for Children. This is the primary site for most of the pediatric patient-oriented research conducted at IU School of Medicine, the Department of Pediatrics, and Indiana Clinical and Translational Sciences Institute. The Translational Research and Integrated Biology Lab facility is housed within this facility and is the site of the Division of Pediatric Pulmonology, Allergy and Sleep Medicine’s storage freezers, lab equipment and workspace for laboratory technicians.

Specialty Areas of Pulmonary, Allergy and Sleep Medicine Research

The Aerodigestive team in the Division of Pediatric Pulmonology, Allergy and Sleep Medicine aims to provide multidisciplinary care to pediatric patients with complex airway and gastrointestinal problems to improve clinical outcomes by coordinating evaluations and operative procedures while providing an educational environment for trainees entering the field of aerodigestive care. In addition, this team is tailoring its management approach to encourage the implementation of research protocols.

Clinical Trials

Pediatric Pulmonology, Allergy and Sleep Medicine faculty lead and participate in a number of research trials ranging from asthma to Primary Ciliary Dyskinesia and Cystic Fibrosis, allowing pediatric pulmonary fellows to focus in their specific area of interests. The division is involved in both investigator-initiated and pharmaceutical sponsor trials with more than 70 ongoing protocols. The division also has a dedicated research team that includes a research director, twelve research coordinators/nurses, two respiratory therapists and a regulatory specialist. This team has wide-ranging experience in recruiting patients for research studies.