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Indiana University School of Medicine
Indiana University School of Medicine
Pediatrics

Recent Publications

  • PrecISE- A Biomarker Stratified Adaptive Trial of 5 Interventions in Severe Asthma: Final Protocol and the Baseline Cohort. Denlinger LC, Israel E, Moore WC, Georas SN, Wright RJ, Castro M, Peden DB, Anstrom KJ, Bleecker ER, Alexander LC, Cahill KN, Cardet JC, Carr TF, Cedano J, Chen AY, Chupp GL, Comhair SAA, DiMango EA, Erzurum SC, Fahy JV, Fajt ML, Gaston BM, Jackson DJ, Jain S, Jarjour NN, Kenyon NJ, Kraft M, Krishnan JA, Kumar R, Lugogo NL, Martinez FD, Marquis MA, Pappalardo AA, Phipatanakul W, Rank MA, Rosenberg SR, Salciccioli JD, Sanchez M, Smith LJ, Sumino K, Szefler SJ, Tang M, Vijayanand P, Wechsler ME, Wenzel SE, White SR, Zeki AA, Ivanova A, Bacharier LB, Akuthota P; NHLBI PrecISE Study Team.J Allergy Clin Immunol. 2026 Feb 16:S0091-6749(26)00082-5. doi: 10.1016/j.jaci.2026.02.001. Online ahead of print.PMID: 41707916

  • PrecISE: Precision Medicine in Severe Asthma: An adaptive platform trial with biomarker ascertainment. Israel E, Denlinger LC, Bacharier LB, LaVange LM, Moore WC, Peters MC, Georas SN, Wright RJ, Mauger DT, Noel P, Akuthota P, Bach J, Bleecker ER, Cardet JC, Carr TF, Castro M, Cinelli A, Comhair SAA, Covar RA, Alexander LC, DiMango EA, Erzurum SC, Fahy JV, Fajt ML, Gaston BM, Hoffman EA, Holguin F, Jackson DJ, Jain S, Jarjour NN, Ji Y, Kenyon NJ, Kosorok MR, Kraft M, Krishnan JA, Kumar R, Liu AH, Liu MC, Ly NP, Marquis MA, Martinez FD, Moy JN, O'Neal WK, Ortega VE, Peden DB, Phipatanakul W, Ross K, Smith LJ, Szefler SJ, Teague WG, Tulchinsky AF, Vijayanand P, Wechsler ME, Wenzel SE, White SR, Zeki AA, Ivanova A.J Allergy Clin Immunol. 2021 May;147(5):1594-1601. doi: 10.1016/j.jaci.2021.01.037. Epub 2021 Mar 2.PMID: 33667479

  • HSD3B1 genotype identifies glucocorticoid responsiveness in severe asthma. Zein J, Gaston B, Bazeley P, DeBoer MD, Igo RP Jr, Bleecker ER, Meyers D, Comhair S, Marozkina NV, Cotton C, Patel M, Alyamani M, Xu W, Busse WW, Calhoun WJ, Ortega V, Hawkins GA, Castro M, Chung KF, Fahy JV, Fitzpatrick AM, Israel E, Jarjour NN, Levy B, Mauger DT, Moore WC, Noel P, Peters SP, Teague WG, Wenzel SE, Erzurum SC, Sharifi N.Proc Natl Acad Sci U S A. 2020 Jan 28;117(4):2187-2193. doi: 10.1073/pnas.1918819117. Epub 2020 Jan 13.PMID: 31932420

  • Vitamin C supplementation to pregnant smokers alters asthma- and allergy-associated CpGs in child buccal DNA at 5 years of age. Shorey-Kendrick LE, McEvoy CT, Milner K, Harris J, Brownsberger J, Tepper RS, Park B, Gao L, Vu A, Morris CD, Thompson EE, Ober C, Spindel ER.Clin Epigenetics. 2025 Oct 3;17(1):155. doi: 10.1186/s13148-025-01965-2.PMID: 41044653

  • A phase I study targeting the APE1/Ref-1 redox signaling protein with APX3330: first clinical agent targeting APE1/Ref-1 in cancer. Kelley MR, Wan J, Liu S, Kpenu E, Wireman R, Mosley AL, Liu H, Lakhani NJ, Shahda S, O'Neil B, Opyrchal M, Messmann RA.Oncologist. 2026 Jan 17;31(2):oyaf423. doi: 10.1093/oncolo/oyaf423.PMID: 41423797

  • New Ref-1/APE1 targeted inhibitors demonstrating improved potency for clinical applications in multiple cancer types. Gampala S, Moon HR, Wireman R, Peil J, Kiran S, Mitchell DK, Brewster K, Mang H, Masters A, Bach C, Smith-Kinnamen W, Doud EH, Rai R, Mosley AL, Quinney SK, Clapp DW, Hamdouchi C, Wikel J, Zhang C, Han B, Georgiadis MM, Kelley MR, Fishel ML.Pharmacol Res. 2024 Mar;201:107092. doi: 10.1016/j.phrs.2024.107092. Epub 2024 Feb 2.PMID: 38311014

  • New Ref-1/APE1 targeted inhibitors demonstrating improved potency for clinical applications in multiple cancer types. Gampala S, Moon HR, Wireman R, Peil J, Kiran S, Mitchell DK, Brewster K, Mang H, Masters A, Bach C, Smith-Kinnamen W, Doud EH, Rai R, Mosley AL, Quinney SK, Clapp DW, Hamdouchi C, Wikel J, Zhang C, Han B, Georgiadis MM, Kelley MR, Fishel ML.Pharmacol Res. 2024 Mar;201:107092. doi: 10.1016/j.phrs.2024.107092. Epub 2024 Feb 2.PMID: 38311014

  • Effect of bevacizumab on non-target intracranial meningiomas and non-vestibular schwannomas in NF2-related schwannomatosis: NF104. Nakhate V, Ly I, Muzikansky A, Rapalino O, Allen JC, Blakeley JO, Campian JL, Clapp DW, Dhall G, Jain RK, Karajannis MA, Packer RJ, Tonsgard J, Ullrich NJ, Korf BR, Fisher MJ, Plotkin SR; Neurofibromatosis Clinical Trials Consortium.J Neurooncol. 2025 Jul;173(3):751-757. doi: 10.1007/s11060-025-05020-1. Epub 2025 May 28.PMID: 40434540

  • Selumetinib in adults with NF1 and inoperable plexiform neurofibroma: a phase 2 trial. Gross AM, O'Sullivan Coyne G, Dombi E, Tibery C, Herrick WG, Martin S, Angus SP, Shern JF, Rhodes SD, Foster JC, Rubinstein LV, Baldwin A, Davis C, Dixon SAH, Fagan M, Ong MJ, Wolters PL, Tamula MA, Reid O, Sankaran H, Fang F, Govindharajulu JP, Browne AT, Kaplan RN, Heisey K, On TJ, Xuei X, Zhang X, Johnson BC, Parchment RE, Clapp DW, Srivastava AK, Doroshow JH, Chen AP, Widemann BC.Nat Med. 2025 Jan;31(1):105-115. doi: 10.1038/s41591-024-03361-4. Epub 2025 Jan 6.PMID: 39762421

  • Cabozantinib for neurofibromatosis type 1-related plexiform neurofibromas: a phase 2 trial. Fisher MJ, Shih CS, Rhodes SD, Armstrong AE, Wolters PL, Dombi E, Zhang C, Angus SP, Johnson GL, Packer RJ, Allen JC, Ullrich NJ, Goldman S, Gutmann DH, Plotkin SR, Rosser T, Robertson KA, Widemann BC, Smith AE, Bessler WK, He Y, Park SJ, Mund JA, Jiang L, Bijangi-Vishehsaraei K, Robinson CT, Cutter GR, Korf BR; Neurofibromatosis Clinical Trials Consortium; Blakeley JO, Clapp DW.Nat Med. 2021 Jan;27(1):165-173. doi: 10.1038/s41591-020-01193-6. Epub 2021 Jan 13.PMID: 33442015

Elexacaftor/Tezacaftor/Ivacaftor Supports Treatment for CF with ΔI1023-V1024-CFTR. Huang Y, Gonzales Cordova JM, Penrod S, Bendy LL, Cheng PC, Sanders DB, Davis MD, Gaston B, Chmiel JF.Int J Mol Sci. 2025 May 31;26(11):5306. doi: 10.3390/ijms26115306.PMID: 40508114

  • Vitamin C Supplementation Among Pregnant Smokers and Airway Function Trajectory in Offspring: A Secondary Analysis of a Randomized Clinical Trial. McEvoy CT, Shorey-Kendrick LE, MacDonald KD, Park BS, Spindel ER, Morris CD, Tepper RS.JAMA Pediatr. 2024 Jun 1;178(6):616-618. doi: 10.1001/jamapediatrics.2024.0430.PMID: 38587836

  • Vitamin C supplementation improves placental function and alters placental gene expression in smokers. Shorey-Kendrick LE, McEvoy CT, O'Sullivan SM, Milner K, Vuylsteke B, Tepper RS, Morgan TK, Roberts VHJ, Lo JO, Frias AE, Haas DM, Park B, Gao L, Vu A, Morris CD, Spindel ER.Sci Rep. 2024 Oct 26;14(1):25486. doi: 10.1038/s41598-024-73005-7.PMID: 39461975

In Vivo Analysis of Tissue S-Nitrosothiols in Pediatric Sepsis. Cater DT, Clem C, Marozkina N, Gaston B.Antioxidants (Basel). 2024 Feb 21;13(3):263. doi: 10.3390/antiox13030263.PMID: 38539797

Phase I Clinical Trial of Islet Antigen-Specific Plasmid Coexpressing Tolerogenic Proteins Demonstrates Safety in Adults With Type 1 Diabetes. Greenbaum CJ, Long SA, Gitelman SE, Gaglia JL, Daniels M, Brusko TM, Lord S, Bundy BN, Krischer JP, Haller MJ, Steck AK, DiMeglio LA, Evans-Molina C, Moran A, Prahalad P, Wilson DM, Russell WE, Sherr JL, Raskin P, Clements MA, Moore WV, Libman I, Wassermann K, von Herrath M, Bergholdt R, Hastrup H, Kobernat SE, Kus AM, Tung LW, Goland RS, Herold KC; Type 1 Diabetes TrialNet Study Group*.Diabetes. 2026 Mar 1;75(3):506-518. doi: 10.2337/db25-0777.PMID: 41564354

  • A Treatment to Eliminate SARS-CoV-2 Replication in Human Airway Epithelial Cells Is Safe for Inhalation as an Aerosol in Healthy Human Subjects. Davis MD, Clemente TM, Giddings OK, Ross K, Cunningham RS, Smith L, Simpson E, Liu Y, Kloepfer K, Ramsey IS, Zhao Y, Robinson CM, Gilk SD, Gaston B.Respir Care. 2021 Jan;66(1):113-119. doi: 10.4187/respcare.08425. Epub 2020 Sep 22.PMID: 32962996

  • Effectiveness of a short-term oxygen therapy training program in Liberia during and after COVID-19. Luke MB, Ziah M 2nd, Lu LZN, Davis MD, Arzoaquoi S, Drucker E, Kanneh F, Logan GG, Massaquoi M.Front Public Health. 2025 Feb 12;13:1490134. doi: 10.3389/fpubh.2025.1490134. eCollection 2025.PMID: 40013036