CPT Code(s): 88237, 88275, 88271 (x per probe)
Service Code (IU Health): 53101259, 53100707, 53100640
Ordering Recommendation: For diagnosis of new cases of multiple myeloma or other plasma cell proliferative disorders, or to confirm diagnosis and establish prognostic grouping important for subsequent therapy. Companion testing with chromosome analysis will help in further delineating chromosomal abnormalities.
Synonyms: FISH, Hematopoietic malignancy, Plasma Cell Myeloma, Multiple Myeloma, Plasma Cell Proliferative Disorder, Monoclonal Gammopathy of Unknown Significance (MGUS)
Methodology: Fluorescence in situ hybridization (FISH) analysis.
Performed: Monday through Friday
Reported: 2-3 days
Panels: PCM Panel - 1q/8p, 5q, 7q, t(11;14), D13S319/RB1, IGH, TP53/CEP 17 If IGH=abnormal, reflex to t(4;14) and t(14;16). Each probe may be run individually.