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Indiana University School of Medicine
Indiana University School of Medicine
Internal Medicine

Didactics

Academy of Teaching ScholarsThe fellowship program involves a series of didactic classes designed to provide basic skills in clinical design, pharmacokinetics and pharmacogenetics, biomarker assessment and development, as well as ethical issues in clinical research. Didactic courses take place within a rich academic research environment that involves the study of therapeutics in humans of all ages and ethnicities.

Clinical Pharmacology Friday Didactic Schedule

August 29, 2025
Drug Measurement 2 -- macromolecular drugs
Ronald Bowsher, PhD

September 5, 2025
Drug Measurement 1  -- small molecules
Lais Da Silva, PhD

September 19, 2025
Kinetics Following and Intravenous Bolus Dose
Richard Bergstrom, PhD and Lais Da Silva, PhD

September 26, 2025
Membranes and Distribution
Lais Da Silva, PhD

October 3, 2025
Elimination
Steve Hall, PhD

October 10, 2025
Constant Rate Input
Rich Bergstrom, PhD

October 17, 2025
Kinetics Following an Extravascular Dose
Kevin Sowinski, PhD

October 24, 2025
Absorption
TBD

October 31, 2025
Response Following a Single Dose; Therapeutic Window
Brian Overholser, PharmD

November 7, 2025
Multiple Dose Regimens; Initiating and Managing Therapy
Rich Bergstrom, PhD

November 14, 2025
Variability; Genetics; Drug Interactions
Sara Quinney, PharmD, PhD

November 21, 2025
Age, Weight, and Gender; Disease
Sara Quinney, PharmD, PhD

December 5, 2025
Metabolite and Drug Response
Steve Hall, PhD

December 12, 2025
Distribution Kinetics
Sara Quinney, PharmD, PhD

March 14, 2025
Toxicology
Thomas Jones, PhD

March 21, 2025
NO DIDACTICS - 14th Annual Indiana CTSI Pharmacometrics Modeling and Simulation Symposium

March 28, 2025
Introduction/Phase I
Eric A. Benson, MD, PhD

April 4, 2025
NO DIDACTICS

April 11, 2025
Biomarker Development
Tom Callaghan, MD, PhD

April 18, 2025
Precision Oncology Trials
William Macais, MD, PhD

April 25, 2025
Role of Modeling
Robert Stratford, PhD

May 2, 2025
Preclinical Pharmacology
Sitta Sittampalam, PhD

May 9, 2025
Special Populations: Gender, Disease, Age, and Other Covariates
Rich Bergstrom, PhD

May 16, 2025
Special Populations: Hepatic/Renal Impaired States
Michael Eadon, MD

May 23, 2025
Ethical Considerations and Rate Diseases
Matt Rotelli, PhD

May 30, 2025
Late Phase Trial Development
William Macias, MD, PhD

Aug. 9, 2024
Pharmacogenetics: General Concepts
Todd Skaar, PhD

Aug. 16, 2024
Genotyping and Sequencing I
Todd Skaar, PhD

Aug. 23, 2024
Genotyping and Sequencing II
Todd Skaar, PhD

Aug. 30, 2024
Drug Metabolism Overview
Zeruesenay Desta, PhD

Sept. 6, 2024
Clinical Relevance of CYP2Cs Genetic Polymorphism Part 1
Zeruesenay Desta, PhD

Sept. 13, 2024
Clinical Relevance of CYP2Cs Genetic Polymorphism Part 2
Zeruesenay Desta, PhD

Sept. 20, 2024
Clinical Pharmacogenomics Testing
Victoria Pratt, PhD, FACMG

Sept. 27, 2024
Pharmacogenetics of Phase II Metabolism: Glucuronidation and Thiopurine Methyltransferase #2
Zeruesenay Desta, PhD

Oct. 4, 2024
Pharmacogenetics of CYP2D6
Todd Skaar, PhD

Oct. 11, 2024
Pharmacogenetics of CYP3A
Todd Skaar, PhD

Oct. 18, 2024
Pharmacogenomics of Drug Transporters and Pharmacogenomics of Hypertension Therapies
Michael Eadon, MD

Oct. 25, 2024
PGx Extraction
Tyler Shugg, PharmD, PhD

Nov. 1, 2024
Phenoconversions
Tom Callaghan, MD, PhD

Nov. 8, 2024
GWAS, Polygenic Models, and Secondary Big Data Analysis
Nick Powell, PharmD

Nov. 15, 2024
Opioid Pharmacodynamics
Tom Callaghan, MD, PhD

Nov. 22, 2024
Clinical Implementation of Pharmacogenomic Testing
Emma Tillman, PharmD, PhD

Nov. 29, 2024
No Didactics - Day after Thanksgiving

Dec. 6, 2024
Cancer Somatic Genomics
Patrick Kiel, PharmD

Dec. 13, 2024
QT Prolongation
Brian Overholser, PharmD, FDCP

January 19, 2024
Statistical Analysis 1: Continuous Data
Paul Berg, MS and Forrest Williamson, PhD, MS

January 26, 2024
Statistical Analysis 2: Categorical Data
Paul Berg, MS and Forrest Williamson, PhD, MS

February 2, 2024
Statistical Tests and Model Building
Paul Berg, MS and Forrest Williamson, PhD, MS

February 9, 2024
Human Studies 1 (Design)
Paul Berg, MS and Forrest Williamson, PhD, MS

February 16, 2024
Human Studies 2 (Analysis/Interpretations)
Paul Berg, MS and Forrest Williamson, PhD, MS

February 23, 2024
Statistical Methods for Clinical Pharmacology
Paul Berg, MS and Forrest Williamson, PhD, MS

August 25, 2023
Drug Measurement 1 -- Small Molecules
Lais Da Silva, PhD

September 1, 2023
Drug Measurement 2 -- Macromolecular Drugs
Ronald Bowsher, PhD

September 8, 2023
Therapeutic Relevance; Fundamental Concepts and Terminology
Richard Bergstrom, PhD and Brian Overholser, PharmD

September 15, 2023
Kinetics Following and Intravenous Bolus Dose
Kevin Sowinski, PharmD

September 22, 2023
Membranes and Distribution; Distribution Kinetics
Sara Quinney, PharmD, PhD

September 29, 2023
Elimination
Brian Overholser, PharmD

October 6, 2023
Kinetics Following an Extravascular Dose; Absorption
Kevin Sowinski, PharmD

October 13, 2023
Constant-Rate Input
Lais Da Silva, PhD

October 20, 2023
Response Following a Single Dose; Therapeutic Window
Brian Overholser, PharmD

October 27, 2023
Multiple Dose Regimens; Initiating and Managing Therapy
Richard Bergstrom, PhD

November 3, 2023
Metabolite and Drug Response; Drug Interaction
Lais Da Silva, PhD

November 10, 2023
Variability; Genetics; Age, Weight, Gender, Disease
Sara Quinney, PharmD, PhD

November 17, 2023
Variability; Genetics; Age, Weight, Gender, Disease
Sara Quinney, PharmD, PhD

November 24, 2023
NO CLASS - THANKSGIVING BREAK

December 1, 2023
Nonlinearities
Sara Quinney, PharmD, PhD

December 8, 2023
Protein Drugs; Predictions of Human PK from Preclinical
Richard Bergstrom, PhD

December 15, 2023
TAKE HOME FINAL EXAMINATION

February 3, 2023
Introduction/Phase 1
Eric Benson, MD and Tom Callaghan, MD, PhD

February 10, 2023
Toxicology
Thomas Jones, PhD

February 17, 2023
Application of Artificial Intelligence and Machine Learning for Precision Medicine
Workshop by Indiana CTSI WGHI Winter Retreat

February 24, 2023
NO DIDACTIC - SYMPOSIUM

March 3, 2023
Biomarker Development
Tom Callaghan, MD, PhD

March 10, 2023
Precision Oncology Trials
Tom Callaghan, MD, PhD

March 17, 2023
NO DIDACTIC - SPRING BREAK

March 24, 2023
Preclinical Pharmacology
Andrew Dahlem, DVM (hc), PhD

March 31, 2023
Late Phase Trial Development
William Macias, MD, PhD

April 7, 2023
Role of Modeling
Robert Stratford, PhD

April 14, 2023
Ethical Considerations and Rare Diseases
Tim Franson, MD

April 21, 2023
Special Populations: Gender, Disease, Age, and Other Covariates
Richard Bergstrom, PhD
 
April 28, 2023
Special Populations: Hepatic/Renal Impaired States
Michael Eadon, MD

August 12, 2022
Pharmacogenetics: General Concepts
Todd Skaar, PhD

August 19, 2022
Clinical Relevance of CYP2Cs Genetic Polymorphism I
Zeruesenay Desta, PhD

August 23, 2022
Genotyping and Sequencing I (SPECIAL DAY - HELD ON TUESDAY IN LIEU OF SEMINAR)
Todd Skaar, PhD

August 26, 2022
Genotyping and Sequencing II
Todd Skaar, PhD

September 2, 2022
Clinical Relevance of CYP2Cs Genetic Polymorphism II
Zeruesenay Desta, PhD

September 9, 2022
Pharmacogenetics of Phase II Metabolism: Glucuronidation
Zeruesenay Desta, PhD

September 16, 2022
Pharmacogenetics of Phase II Metabolism: N-acetylation and Thiopurine Methyltransferase
Zeruesenay Desta, PhD

September 23, 2022
Pharmacogenetics of CYP2D6
Todd Skaar, PhD

September 30, 2022
Pharmacogenomics of CYP3A
Todd Skaar, PhD

October 7, 2022
GWAS, Polygenic Models, and Secondary Big Data Analysis
Nick Powell, PharmD

October 14, 2022
Phenoconversions 
Tom Callaghan, MD, PhD

October 21, 2022
Clinical Implementation of Pharmacogenomic Testing
Emma Tillman, Pharm D, PhD

October 28, 2022
Clinical Pharmacogenomics Testing
Victoria Pratt, PhD, FACMG

November 4, 2022
Opioid Pharmacodynamics
Tom Callaghan, MD, PhD

November 11, 2022
QT Prolongation
Brian Overholser, PharmD, FDCP

November 18, 2022
Pharmacogenomics of Drug Transporters
Michael Eadon, MD

November 25, 2022
No Didactics - Day After Thanksgiving Holiday

December 2, 2022
Pharmacogenomics of Hypertension Therapies
Michael Eadon, MD

December 9, 2022
PGx Extraction
Tyler Shugg, PharmD, PhD

December 16, 2022
Cancer Somatic Genomics
Patrick Kiel, PharmD

January 21, 2022
Univariate Continuous Statistical Data Analysis
Forrest Williamson, PhD

January 28, 2022
Univariate Categorical Statistical Data Analysis
Forrest Williamson, PhD

February 4, 2022
Statistical Tests and Model Building
Forrest Williamson, PhD and Paul H Berg, MS

February 11, 2022
Human Studies 1 (Design)
Paul H Berg, MS

February 25, 2022
Human Studies 2 (Analysis/Interpretations)
Forrest Williamson, PhD and Paul H Berg, MS

March 4, 2022
Statistical Methods Useful in Clinical Pharmacology
Paul H Berg, MS

August 17, 2021
Drug Measurement 1 - small molecule
Andi Masters, MS

September 3, 2021
Drug Measurement 2 - macromolecular drugs
Ronald Bowsher, PhD

September 10, 2021
Therapeutic Relevance; Fundamental Concepts and Terminology
Rich Bergstrom, PhD and Brian Overholser, PharmD

September 17, 2021
Kinetics Following and Intravenous Bolus Dose
Kevin Sowinski, PharmD

September 24, 2021
Membranes and Distribution; Distribution Kinetics
Sara Quinney, PhD

October 1, 2021
Elimination
Brian Overholser, PharmD

October 8, 2021
Kinetics Following an Extravascular Dose; Absorption
Kevin Sowinski, PharmD

October 15, 2021
Constant-Rate Input
Robert Stratford, PhD

October 22, 2021
Response Following a Single Dose; Therapeutic Window
Brian Overholser, PharmD

October 29, 2021
Multiple Dose Regimens; Initiating and Managing
Rich Bergstrom, PhD

November 5, 2021
Metabolite and Drug Response; Drug Interaction
Robert Stratford, PhD

November 12, 2021
Variability; Genetics; Age, Weight, Gender, Disease
Sara Quinney, PhD

November 19, 2021
Variability; Genetics; Age, Weight, Gender, Disease
Sara Quinney, PhD

November 26, 2021
NO CLASS - THANKSGIVING BREAK

December 3, 2021
Nonlinearities
Sara Quinney, PhD

December 10, 2021
Protein Drugs; Predictions of Human PK
Rich Bergstrom, PhD

December 17, 2021
TAKE HOME FINAL EXAM

April 16, 2021
Special Populations - Pregnancy
Sara K. Quinney, PhD

April 23, 2021
Special Populations - Geriatric
J. Thomas Callaghan, MD, PhD

April 30, 2021
Special Populations - Hepatic / Renal
Michael T. Eadon, MD

August 14, 2020
Pharmacogenetics: General Concepts
Todd Skaar, PhD

August 21, 2020
Clinical Relevance of CYP2C9 and CYP2C19 Genetic Polymorphism
Zeruesenay Desta, PhD

August 28, 2020
Genotyping and Sequencing I
Todd Skaar, PhD

September 4, 2020
Clinical Relevance of CYP2Cs Genetic Polymorphism
Zeruesenay Desta, PhD

September 11, 2020
Genotyping and Sequencing II
Todd Skaar, PhD

September 18, 2020
Pharmacogenetics of Phase II Metabolism: Glucuronidation
Zeruesenay Desta, PhD

September 25, 2020
Pharmacogenetics of Phase II Metabolism: N-acetylation and Thiopurine Methyltransferase
Zeruesenay Desta, PhD

October 2, 2020
Pharmacogenetics of CYP2D6
Todd Skaar, PhD

October 9, 2020
Pharmacogenomics of CYP3A
Todd Skaar, PhD

October 16, 2020
Phenoconversions
Tom Callaghan, MD, PhD

October 23, 2020
No Didactics

October 30, 2020
No Didactics

November 6, 2020
Opioid Pharmacodynamics
Tom Callaghan, MD, PhD

November 13, 2020
QT Prolongation
Brian Overholser, PharmD, FDCP

November 20, 2020
Pharmacogenomics of Drug Transporters
Michael Eadon, MD

December 4, 2020
Pharmacogenomics of Hypertension Therapies
Michael Eadon, MD

December 11, 2020
Clinical Pharmacogenomics Testing
Victoria Pratt, PhD, FACMG

January 10, 2020
Statistical Analysis 1: Continuous Data
Forrest Williamson, PhD

January 17, 2020
Statistacal Analysis 2 Categorical Data
Forrest Williamson, PhD

January 24, 2020
Statistical Tests and Model Building
Fanni Natanegara, PhD

January 30, 2020
Human Studies 1 (Design)
Paul H. Berg, MS

February 7, 2020
Human Studies 2 (Analysis/Interpretations)
Fanni Natanegara, PhD

February 14, 2020
Statistical Methods for Clinical Pharmacology
Paul H. Berg, MS