CPT Code(s): 88237, 88275, 88271 (x per probe)
Service Code (IU Health): 53101259, 53100707, 53100640
Ordering Recommendation: FISH is useful for (1) detection of a neoplastic clone that is associated with chromosome abnormalities observed in patients with MPN, (2) to evaluate specimens in which standard cytogenetic analysis has been unsuccessful, and (3) to identify and track chromosome abnormalities for follow-up of patients and evaluate response to therapy.
Synonyms: FISH, hematopoietic malignancy, myeloproliferative neoplasms, MPN, chronic myelogenous leukemia, CML, polycythemia vera, PV, myelofibrosis, PMF, essential thrombocythemia, ET, fluorescence in situ hybridization
Methodology: Fluorescence in situ hybridization (FISH) analysis.
Performed: Monday through Friday
Reported: 2-3 days
Panels: MPN Panel - 5q, 7q, CEP 8/20q, BCR/ABL1/ASS Each probe may also be run individually. Also available: FIP1L1-LNX1-PDGFRA and PDGFRB