Participate in your grant and/or provide a letter of support
Provide lab space, instrumentation and training for molecule design, synthesis and analysis.
Small molecules as well as peptide design, synthesis, and analysis by LCQTOF/NMR.
Drug, metabolites qualification and quantification by LCQTOF.
Intact Protein characterization and covalent inhibitor drug discovery.
LC/high accurate mass analysis up to four decimals for small molecules, peptides and oligonucleotides
LC/MS for proteins and modified proteins (covalent inhibitors discovery)
LC/MS/MS analysis: targeted and untargeted
Automated purification systems are designed for up to 150g of sample per run, whether natural product extracts or other organic compound mixtures from chemistry.
The Waters 2545 Quaternary Gradient Module (QGM) is a low-pressure mixing quaternary graident pump that serves as a solvent delivery device for AutoPurification Systems. Waters Fraction Collector III is an easy-to-use, standalone or software-controlled fraction collector.
Efficient and controlled heating via microwave
Accelerated organic reactions
Hetereocycles, cross-coupling reactions
Total Collection: ~220,000 compounds
Diversity-Oriented Small Molecules
LOPAC 1280: Includes 1,280 known drugs and bioactives, covering all major target classes, including CPCRs and kinases
Microsource Spectrum: Comprises 2,400 US and international drugs, natural products and their derivatives, and reported bioactives (non-drug enzyme inhibitors, receptor blockers, membrane active compounds, and cellular toxins) that have not made it to clinical trials
AnalytiCon MEGx: Comprises 1,000 pur natural products extracted and purified from plants and microorganisms
AnalytiCon NATx: Includes 5,000 semi-synthetic natural products that were built based on natural product precursors with tractable chemistry
| Instrument | Unit | Internal Price |
|---|---|---|
| Molecule design, synthesis and analysis labor | Per Hour | $80 |
| Molecule design, synthesis and analysis project | Per Hour | $120 |
|
Agilent 1290 LC - 6545 QTOF |
Per Hour | $75 |
| Stuart Melting Point Meter | Per Hour | $25 |
| Polarimeter | Per Hour | $25 |
| Chemical Hood and Space | Daily Per Chemist | $25 |
| Biotage Microwave Reactor | Per Hour | $40 |
| Waters Preparative HPLC | Per Hour | $74 |
| Buchi Evaporation System | Per Hour | $25 |
| Biotage Flash Purification System | Per Hour | $71 |
| Multichannel N2 Dryer | Per Hour | $25 |
Material cost for instrument usage will be charged separately if it occurs.
For instrument training and assisted instrument usage, labor rate will be added to the specific instrument rate.
Rates for external non-profit organizations and external profit organization are also available.
Please contact Lifan Zeng, PhD, for more information.
