Wells Center News and Events

The Herman B Wells Center for Pediatric Research is home to a vibrant community of experts who proudly share their latest advances in pediatric research through scholarly publications, news, stories and engaging seminars.

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Wells Center Seminar Series

The Wells Center Seminar Series seeks to foster the rich dynamic and collaborative culture of the center while promoting regular interaction between investigators at all levels.

The program is overseen by Jason M. Spaeth, PhD, assistant director of faculty enrichment and development at the Wells Center, and organized by Shari Parker, program manager of special events.

The series features educational presentations from external experts, discussions with professionals within the institution’s vast internal network, interactive breakout sessions and more.

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Featured News and Stories

Pediatrics

Recent publications featuring Wells Center authors

“Aptamers in cancer therapy: Why has clinical translation lagged behind preclinical promise?” Published in Biomedicine & Pharmacotherapy. Contributing IU authors: Thoa T. Tran, Melissa L. Fishel, Jianjun Zhang, Salvatore Condello, Xiaoling Zhong, Max Schmidt
“Association of Food Insecurity and Short-Term Kidney Outcomes in Neonates.” Published in American Journal of Perinatology. Contributing IU authors: Michelle C. Starr, Abigail C. Hardy, Paulomi Chaudhry, Cara L. Slagle, Danielle E. Soranno
“BACH2 links β1-adrenergic receptor/β-arrestin1 signaling to MIAT to inhibit cardiac fibroblast activation and cardiomyocyte apoptosis.” Published in Cell Death Discovery. Contributing IU authors: Bruno Moukette, Jian-Peng Teoh, Waleed J. Hashmi, Satoshi Kawaguchi, Tatsuya Aonuma, Hamedane Moustapha, Steven S. Welc, Simon J. Conway, Suthat Liangpunsakul, Lei Yang, Ankit A Desai, Il-Man Kim
“Beta cell glucose sensitivity identifies clinical response to disease-modifying therapies initiated at stage 3 type 1 diabetes onset.” Published in Diabetologia. Contributing IU author: Carmella Evans-Molina.
“Beta cell microRNAs function as molecular hubs of type 1 diabetes pathogenesis and as biomarkers of diabetes risk.” Published in Diabetologia. Contributing IU authors: Farooq Syed, Preethi Krishnan, Garrick Chang, Jyoti Rana, Sarah R. Langlais, Sumon Hati, Kentaro Yamada, Anh K. Lam, Sayali Talware, Jacqueline Del Carmen Aquino, Eli Hagedorn, Rajesh Sardar, Carmella Evans-Molina
“Beyond 100 years of vitamin E and related molecules - Milestones and open challenges.” Published in Molecular Aspects of Medicine. Contributing IU authors: Joan Cook-Mills, Jacquelyn Lajiness
“Chemical inhibition of a bacterial immune system.” Published in Cell Host & Microbe. Contributing IU authors: Zhiyu Zang, Olivia K. Duncan, Yanyao Cai, Chengqian Zhang, Shelley A. H. Dixon, Steven P. Angus, Joseph P. Gerdt
“Conserved pathogenesis of ancestral and contemporary Oropouche virus strains in a murine pregnancy model.” Published in Nature Communications. Contributing IU authors: Krista B. Gunter, James M. Bowen, Dorcus C. A. Omoga, Stephanie Pozuelos, Henry Giesel, Curtis Witt, Lisa M. Rogers, David M. Aronoff, Andrew M. Lunel, Jay Vornhagen, Natasha L. Tilston
“CRISPR-Cas9-mediated homology-directed repair rescues the induced bone marrow failure in Fancc−/− mice.” Published in Molecular Therapy - Nucleic Acids. Contributing IU authors: Hemavathy Harikrishnan, Mahesh Lamsal, Ka-Kui Chan, Junping Zhang, Kwadwo Fosu, Hong Phuong Nguyen, D. Wade Clapp, Elizabeth A. Sierra Potchanant, Reuben Kapur, Weidong Xiao, Ngoc Tung Tran
“Current Status of Clinical Gene Therapy for Hemophilia and Globin Disorders.” Published in Journal of Blood Medicine. Contributing IU authors: Rebecca Winkler, Ishan Herath, Radoslaw Kaczmarek, Weidong Xiao, Roland W. Herzog, Paige E. Severeid
“Deaths in gene therapy of Duchenne muscular dystrophy and other diseases: Underlying mechanisms and mitigating strategies.” Published in Molecular Therapy. Contributing IU author: Roland W. Herzog
“Deficient Cardiolipin Remodelling Alters Muscle Fibre Composition and Neuromuscular Connectivity in Barth Syndrome.” Published in Journal of Cachexia, Sarcopenia and Muscle. Contributing IU authors: Catalina Matias, Paige L. Snider, Elizabeth A Sierra Potchanant, Joshua R. Huot, Simon J. Conway, Jeffrey J. Brault
“Development of a Novel Method to Detect AAV Vector Integration.” Published in Viruses. Contributing IU authors: Junping Zhang, Thao Thi Dang, Tsai-Yu Lin, Xiangping Yu, Jiahe Tian, Olga Simmons, Emma Kou, Kenneth Cornetta, Weidong Xiao
“Differential Trajectories of Airway and Parenchymal Function in Infants Born Preterm.” Published in The Journal of Pediatrics. Contributing IU authors: Robert S. Tepper, Jeffrey Bjerregaard, Christina Tiller, Laura Amos, Greg Sokol
“Effect of temperature and preservative selection on C-peptide degradation in randomly voided urine.” Published in Journal of Clinical and Translational Endocrinology. Contributing IU authors: Eli H. Hagedorn, Cameron R. Rostron, Anthony Acton, Mallory Oswalt, Robert V. Considine, Carmella Evans-Molina
“Factor VIII originates primarily from anatomically distinct subsets of liver sinusoidal endothelial cells.” Published in Blood Advances. Contributing IU authors: Paige E. Severeid, Wenjun Zhang, Chandrashekhar A. Kubal, Renzhi Han, Sreevani Arisa, Roland W. Herzog, Radoslaw Kaczmarek
“FLT3-SYK inhibitor and Ixazomib combination impact HOXA and oxidative stress control by β-catenin, SQSTM1 and NRF2 in AML.” Published in npj Precision Oncology. Contributing IU authors: Santhosh Kumar Pasupuleti, Sravanti Rangaraju, Justin Layer, Kanaka Sai Ram Padam, Larry D. Cripe, Hamid Sayar, Katie J. Sargent, Jill Weisenbach, Heiko Konig, Huda Salman, Baskar Ramdas, Lakshmi Reddy Palam, Lindsey D. Mayo, Utpal P. Davé, H. Scott Boswell, Reuben Kapur
“Hemophilia A gene therapy: Moving to the next chapter.” Published in Molecular Therapy. Contributing IU authors: Radoslaw Kaczmarek, Roland W. Herzog
“Hemophilia B gene therapy: a NAb–solute barrier overcome by adeno-associated virus serotype 5.” Published in Research and Practice in Thrombosis and Haemostasis. Contributing IU author: Radoslaw Kaczmarek
“Heterogeneous endocrine cell composition defines human islet functional phenotypes.” Published in Nature Communications. Contributing IU author: Carmella Evans-Molina
“Inflammatory Bowel Disease-induced Inflammation Augments Clonal Hematopoiesis of Indeterminate Potential through Ref-1.” Published in Blood. Contributing IU authors: Ramesh Kumar, Rahul Kanumuri, Baskar Ramdas, Santhosh Kumar Pasupuleti, Lakshmi Reddy Palam, Xuepeng Wang, Kanaka Sai Ram Padam, Mark R. Kelley, Reuben Kapur
“Involvement of Periostin in Intestinal Fibrosis Associated With Crohn's Disease.” Published in Journal of Gastroenterology and Hepatology. Contributing IU author: Simon J. Conway
“Ligand binding drives proteolysis of the SmcR master transcription factor and controls quorum sensing-state transitions in Vibrio species.” Published in mBio. Contributing IU authors: Tanmaya A. Rasal, Chelsea A. Simpson, Abigail D. Padgett, Logan J. Geyman, Finley J. Andrew, Laura C. Brown, Julia C. van Kessel
“Meeting Report on FASEB Protein Arginine Methylation: Mechanism to Therapeutics.” Published in Journal of Biological Chemistry. Contributing IU author: Ngoc Tung Tran
“MEK inhibitor Mirdametinib promotes fracture healing in osteofibrous dysplasia RASopathy.” Published in The Journal of Clinical Investigation. Contributing IU author: Simon J. Conway
“Modeling pediatric brain tumors with human stem cells.” Published in Frontiers in Cellular Neuroscience. Contributing IU authors: Noah Burket, Titto Augustine, Jignesh Tailor
“Neurofibromatosis type 1 plexiform neurofibromas: Integrating treatment across pediatric and adult populations.” Published in Neuro-Oncology. Contributing IU author: Steven D. Rhodes
“Parental obesity and risk of metabolic dysfunction associated steatotic liver disease in adult offspring: UK birth cohort study.” Published in Gut. Contributing IU author: Brian Jesse DeBosch
“Progression from Stage 1 to Stage 3 Type 1 Diabetes Characterized by Hypoglycemia.” Published in JCEM Case Reports. Contributing IU authors: Aakash Nagarapu, Jamie L. Felton
“Real-world effectiveness of asthma biologics by age of initiation and early-childhood risk factors.” Published in Annals of the American Thoracic Society. Contributing IU authors: Arthur H. Owora, Kirsten Kloepfer, Robert Tepper, Nadia Krupp, Samantha H. Averill, Ryan C. Unruh, Bowen Jiang, Yash Shah, Benjamin Gaston, Erick Forno
“Ref-1 drives ulcerative colitis induced systemic defects in hematopoietic cells.” Published in Communications Biology. Ramesh Kumar, Rahul Kanumuri, Sarah S. Burns, Baskar Ramdas, Lakshmi Reddy Palam, Santhosh Kumar Pasupuleti, Xuepeng Wang, Mark R. Kelley, Reuben Kapur
“Reframing RB Tumor Suppressor Dysfunction as a Therapeutic Vulnerability in Cancer.” Published in Cancers (Basel). Contributing IU authors: Rada Malko, Harlan E. Shannon, Erika A. Dobrota, Keiko E. Kreklau, Lauren K. Stevens, Kyle W. Jackson, M. Reza Saadatzadeh, Pankita H. Pandya, Karen E. Pollok
“Replication protein A protects lagging strand gaps, restricting PARP inhibitor-induced synthetic lethality in BRCA1-deficient tumors.” Published in Nucleic Acids Research. Contributing IU authors: Pamela S. VanderVere-Carozza, Matthew R. Jordan, Joy E Garrett, Karen E. Pollok, John J. Turchi
“Splenic rupture secondary to pegfilgrastim in a healthy allogeneic peripheral blood hematopoietic stem cell donor.” Published in International Journal of Hematology. Contributing IU author: Daniel Peltier
“Structure-functionality relationship of collagen-fibrin interpenetrating hydrogels for engineered tumor-stroma models.” Published in Acta Biomaterialia. Contributing IU author: Melissa L. Fishel
“Targeting APE1 endonuclease activity impairs metastasis and enhances genotoxic therapy response in pancreatic cancer.” Published in Journal of Experimental & Clinical Cancer Research. Contributing IU authors: Eyram K. Kpenu, Mahmut Mijit, Silpa Gampala, Sheng Liu, Jun Wan, Randall S. Wireman, Jacqueline Peil, Dana K. Mitchell, Sanya Haiaty, Rajesh Sardar, Akanksha Sharma, Millie M. Georgiadis, Melissa L. Fishel, Mark R. Kelley
“Transient prophylactic immunosuppression with abatacept or dasatinib prevents immune responses in AAV gene transfer.” Published in Contributing IU authors: Kentaro Yamada, Miguel Gonzalez-Visiedos, Calista M. Greenwood, Moanaro Biswas, Maite Muñoz-Melero, Sandeep R. P. Kumar, Roland W. Herzog
“Type I Interferons as Contextual Regulators of B-Cell Tolerance in Type 1 Diabetes.” Published in Biomolecules. Contributing IU authors: Mebrahtu G. Tedla, Jamie L. Felton
“Variant burden and severity of cardiomyopathy in patients with DMD-related Duchenne muscular dystrophy.” Published in Pediatric Research. Contributing IU authors: Gabrielle C. Geddes, Stephanie M. Ware, Tae-Hwi Schwantes-An, Marco A. Abreu, John J. Parent, Conner C. Earl, Larry W. Markham

Wells Center News and Events

Explore More

Wells Center Seminar Series

Upcoming Seminars and Events

Featured News and Stories

IU study explains why current hemophilia A gene therapies may be missing the mark

Severe childhood malaria linked to cognitive impairment later in life

Two-pronged strategy targets core survival systems in treatment-resistant blood cancer

IU researchers identify clotting protein as potential target in pancreatic cancer

Hidden blood mutations may be driving severe IBD — IU team uncovers new treatment target

IU research brings kidney stone care into a new era

IU neurofibromatosis specialist named ASCI Young Physician-Scientist awardee

IU blood cancer researcher receives 2026 ASH Scholar Award

More stories from the Wells Center and Department of Pediatrics

Recent publications featuring Wells Center authors