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Translation Core

An important component of research at the Center for Diabetes and Metabolic Diseases is to translate basic and preclinical discoveries to patients. The Translation Core provides services that facilitate and accelerate research involving human subjects, including supplying low-cost, high-quality analyte measurement services for a variety of hormones, cytokines, lipids and other analytes. The core has the capacity to undertake specialized and customizable laboratory services, including development of assays not previously available at IU School of Medicine.

Translation Core human studies services include phenotyping (i.e. GTT, clamp studies), study design and implementation. The core also offers access to a biobank of human tissues and serum. 

The Translation Core has approximately 500 square feet of dedicated space for the analyte lab in the VanNuys Medical Science Building, adjacent to IU Health University Hospital in downtown Indianapolis.

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Assistance with Human Studies

Assistance with Analyte Measures

Human Studies

Human studies are conducted at the Indiana CTSI Clinical Research Center at University Hospital in downtown Indianapolis. This 13,606 square foot space includes 10 inpatient beds/procedure rooms, 14 outpatient rooms, a sample processing laboratory and nurse/physician workspace. The Translation Core has approximately 500 square feet of dedicated space for the analyte lab in the Van Nuys Medical Science Building, adjacent to University Hospital.

Core Services

The following are the most routinely requested measures. If not on the list, interested investigators may inquire about their analyte of interest by contacting the core. Most measures available for both human and rodent samples.

  • Leptin
  • Adiponectin

  • Electrolytes
  • Iron
  • Protein
  • Ferritin
  • Albumin
  • TIBC
  • Creatinine
  • Transferrin
  • Urea
  • Hydroxybutyrate
  • AST
  • Glucose
  • ALT
  • HbA1c

  • Triglycerides
  • Non-esterified Free Fatty Acids
  • Total Cholesterol
  • LDL
  • HDL

  • Insulin
  • Proinsulin
  • C-peptide
  • Glucagon
  • Pancreatic polypeptide

  • GLP-1
  • GIP
  • PYY
  • CCK
  • Ghrelin

  • C-reactive protein
  • IL-6
  • IL-1α
  • IL-8
  • IL-10

Mesoscale Discovery electrochemiluminescence panels for up to 10 analytes per well available.

  • Oral glucose tolerance test
  • Frequently sampled intravenous glucose tolerance tests (FSIVGTT)
  • Meal tolerance test (MTT)
  • Glucagon stimulation test
  • Arginine stimulation test
  • Glucose clamp techniques
  • Body composition -  Dual energy x-ray absorptiometry (DXA)
  • Tissue biobanks
  • Study design
  • Study implementation

Core Leadership and Personnel

4921-Considine, Robert

Robert V. Considine, PhD

Professor of Medicine

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Anthony Acton

Anthony Acton

Research Analyst

4874-Hannon, Tamara

Tamara S. Hannon, MD

Professor of Pediatrics

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Brett McKinney

Brett McKinney

Senior Clinical Research Coordinator/Laboratory Manager