The Bloomington campus of IU School of Medicine is home to advanced research labs for faculty and student research endeavors.
Richard Carpenter, PhD
Researchers in this lab uses proteomics, genomics, and bioinformatics to study how transcription factors are regulated in cancer cells and the subsequent genomic programs induced by these transcription factors. We have a strong interest in transcription factors that play a role in tumor progression, metastasis, and angiogenesis.
David Daleke, PhD
This
lab studies phospholipid transporters, or “flippases,” which help create and
maintain the asymmetric organization of phospholipids in biological membranes
and are essential for normal cell function. Current studies are focused
on the molecular structure of flippases and mechanisms of lipid substrate
stereospecificity.
Peter Hollenhorst, PhD
Researchers in this lab use genomics and bioinformatics approaches to study the mechanisms that ETS family transcription factors use to interact with the genome in an effort to delineate both normal and oncogenic functions of these proteins.
Polly Husmann, PhD
Research focuses on factors outside of the classroom that affect student learning. Examples include study habits, metacognitive skills, self-directed, and self-regulated learning. Studies evaluate these factors in undergraduate, graduate, and medical student populations.
Kenneth P. Nephew, PhD
Investigators in this lab are using next generation sequencing technology and computational models to explore the role of epigenetics in ovarian cancer cells, cancer stem cells and resistance to chemotherapy. The team also studies breast cancer, estrogen receptor biology and endocrine resistance.
Heather M. O’Hagan, PhD
The overall focus of this lab is to determine how epigenetic factors contribute to cancer initiation, progression, and therapy response. We study how standard of care therapies and activated signaling pathways lead to altered epigenetic states that promote cancer progression and therapy resistance.
Jia Shen, PhD, MS
In close collaboration with clinical physicians and surgeons, the Shen laboratory harnesses patient-derived samples to advance brain cancer research. Employing a fusion of cutting-edge computational and experimental methodologies, including single-cell and spatial omics analyses, mouse models, and drug screening, we are dedicated to unraveling the intricate mechanisms underlying brain tumor development and treatment resistance. Our primary mission is to pioneer innovative immunotherapies for brain tumors in adults and children, with a specialized focus on targeting the unique characteristics of cancer stem cells.
Claire Walczak, PhD
Lab is interested in the molecular mechanisms that govern mitotic spindle assembly and chromosome segregation in both normal and tumor-derived cells. Researchers in this group are developing screening assays to identify new drugs that target microtubule assembly.