Skip to main content
PACER logo featuring a red electrocardiogram line that forms a heart shape around the word ‘PACER.’ Below, the text reads ‘Patient-Centered Treatment of Anxiety After Chest Pain in the ER.

PACER (Patient-centered treatment of anxiety after low-risk chest pain in the emergency room) 

Chest pain is the second most common reason for emergency room (ER) visits. Many people who go to the ER for chest pain are at low risk for a heart attack, and in about half of these patients, anxiety is the cause. After being ruled out for heart attack, anxiety often goes untreated, even though addressing it could prevent ongoing symptoms and repeat ER visits.

Cognitive behavioral therapy (CBT), which helps people change thought patterns to improve how they feel, is one way to treat anxiety.

In this study, the research team compared three approaches to treating anxiety in patients who had visited the ER with low-risk chest pain:

  1. Referral to a primary care doctor
  2. Online self-help CBT with peer support
  3. Therapist-led CBT

The team screened ER patients with low-risk chest pain for anxiety and enrolled 375 adults with high anxiety. Participants were randomly assigned to one of the three groups.

  • The first group received a referral to a primary care doctor, who also received the patient’s screening results. Patients also got an educational brochure on anxiety and treatment options.

  • The second group completed an online CBT course with six lessons over 8–12 weeks on managing worry and facing fears, plus peer support from certified recovery specialists. Those with panic symptoms completed two additional exposure therapy lessons.

  • The third group received eight one-hour CBT sessions with a therapist by computer or phone over 12 weeks, with exposure therapy added for patients who experienced panic.

Learn more about PACER

Contact the research team for more information.

PACER Timeline

January 2021

Contract start date

April 2021

Enrolled first participant

August 2022

Reached 50% cumulative enrollment target (n=188)

December 2023

Contract extended with additional funding

July 2024

Met enrollment target (n=375)

August 2025

Completion of data collection for all study aims

November 2025

Submission of draft final research report

December 2026

Contract end date

News Release
Paul Musey, MD and patient

IU School of Medicine awarded $3.4 million to study anxiety in low-risk chest pain patients

Paul Musey, MD is leading a collaborative research project evaluating the most effective way to direct these patients to enhanced care for underlying anxiety.