4910-Chalasani, Naga

Naga P. Chalasani, MD

David W. Crabb Professor of Gastroenterology and Hepatology

Professor of Medicine

Adjunct Professor of Anatomy, Cell Biology & Physiology

Address
702 Rotary Circle, Suite 225

Indianapolis, IN 46202
PubMed:

Bio

Dr. Chalasani completed medical school in India before moving to the United States to pursue an Internal Medicine residency at Emory University in Atlanta, followed by a fellowship in Gastroenterology and Hepatology at the same institution.

He joined Indiana University School of Medicine in 1997 as an Assistant Professor in the Division of Gastroenterology and Hepatology. Dr. Chalasani currently serves as the David W. Crabb Professor of Gastroenterology and Hepatology, Adjunct Professor of Anatomy, Cell Biology & Physiology, and Director of the Terance Kahn Liver Research Program.

Throughout his career, he has held numerous leadership positions, including Chief of the Division of Gastroenterology and Hepatology (2007–2020), Associate Dean for Clinical Research (2017–2020), Interim Chair of the Department of Medicine (2020–2021), and Vice President for Academic Affairs at Indiana University Health (2022–2024).

Dr. Chalasani is a highly regarded clinician who has been recognized as a Top Doctor for more than 15 consecutive years. He has maintained continuous National Institutes of Health (NIH) funding since 1999 and currently serves as Principal Investigator on multiple NIH-funded U01 and R01 awards.

Internationally recognized for his contributions to the fields of metabolic dysfunction-associated steatotic liver disease (MASLD) and drug-induced liver injury (DILI), Dr. Chalasani is among the most published and cited investigators at Indiana University. As of September 2026, his Google Scholar profile reflected an H-index of 130 and more than 87,000 citations. In 2026, he was named Co-Editor-in-Chief of HEPATOLOGY, the flagship journal of the American Association for the Study of Liver Diseases (AASLD), further recognizing his leadership and impact in the field of hepatology.

He is an elected member of the American Society for Clinical Investigation (ASCI), the Association of American Physicians (AAP), and the National Academy of Medical Sciences–India (2024). In addition to his research accomplishments, he has mentored more than 75 undergraduate and graduate students, medical students, subspecialty trainees, and junior faculty members. Twenty of his mentees have gone on to secure federal funding, including K awards, U01, R21, and R01 grants, Department of Defense funding, and VA Merit Review awards.

In recognition of his extraordinary contributions to hepatology research and mentorship, the Naga P. Chalasani Endowed Professorship in Gastroenterology and Hepatology was established at Indiana University School of Medicine in October 2022.

Key Publications

  1. Siddiqui MS, Van Natta ML, Connelly MA, Clark J, Neuschwander-Tetri BA, Diehl AM, Dasarathy S, Loomba R, Chalasani N, Kowdley KV, Hameed B, Wilson LA, Yates KP, Belt P, Kleiner DE, Behling C, Tonascia J, Sanyal AJ. The metabolic vulnerability index predicts outcomes in patients with metabolic dysfunction associated steatotic liver disease. Nat Commun. 2026 Jun 23;17(1):5362. doi: 10.1038/s41467-026-73742-5. PMID: 42337268; PMCID: PMC13291223.

  2. Yoder L, Tapper EB, Kalman R, Rinella M, Bendin N, Verma M, Pike F, Chalasani N, Nalumasu N, Orman ES. The Transitional Liver Clinic: Study protocol for a stepped-wedge cluster randomized trial. Hepatol Commun. 2026 Jun 19;10(7):e0990. doi: 10.1097/HC9.0000000000000990. PMID: 42319136; PMCID: PMC13286549.

  3. Miller K, Wilson LA, Vilar-Gomez E, Samala N, Yuan L, Ajmera V, Kleiner DE, Chalasani N. Histologic severity is identical between normal weight and overweight adults with MASLD: Implications for the definition of lean MASLD. Hepatol Commun. 2026 Jun 12;10(7):e0969. doi: 10.1097/HC9.0000000000000969. PMID: 42275579; PMCID: PMC13263071.

  4. Kaplan LM, Startseva E, le Roux CW, Wharton S, Bozkurt B, Mazo DF, von Schlippenbach J, González Maldonado S, Ajaz Hussain S, Neff GW, Gonzalez Rojas Y, Smith C, Younes R, Sanyal AJ; SYNCHRONIZE-MASLD Investigators. Survodutide in adults with obesity and metabolic dysfunction-associated steatotic liver disease: SYNCHRONIZE-MASLD, a randomized, double-blind, placebo-controlled phase 3 trial. Nat Med. 2026 Aug;32(8):2948-2958. doi: 10.1038/s41591-026-04479-3. Epub 2026 Jun 7. Erratum in: Nat Med. 2026 Aug 25. doi: 10.1038/s41591-026-04650-w. PMID: 42252333; PMCID: PMC13472939.

  5. Dasarathy S, Tu W, Welch N, Gawrieh S, Yu Y, Tang Q, Kettler C, Sanyal AJ, Szabo G, Shah VH, Bataller R, Nagy LE, McClain CJ, Chalasani N, Kerr T, Mitchell MC; for AlcHepNet Investigators. Natural history and development of a novel composite endpoint in patients with alcohol-associated hepatitis: Data from a prospective multicenter study. Hepatology. 2026 Jun 1;83(6):1469-1482. doi: 10.1097/HEP.0000000000001513. Epub 2025 Sep 9. PMID: 40924794; PMCID: PMC12672022.

  6. Chalasani N, Tillman EJ, Billes SK, Rolph T, Noureddin M. Consistent efficacy of efruxifermin across PNPLA3 genotypes in phase 2b trials in MASH. Hepatology. 2026 Aug 1;84(2):617-620. doi: 10.1097/HEP.0000000000001792. Epub 2026 May 12. PMID: 42127430; PMCID: PMC13374643.

  7. Chalasani N, Vuppalanchi R, Noureddin M, Shiffman ML, Lawitz E, Mena E, Gunn NT, Ladron de Guevara L, Elgouhari H, Safadi R, Jamil K, Harrison SA, Alkhouri N. Efficacy and safety of belapectin for the prevention of esophageal varices in patients with MASH cirrhosis: The randomized, placebo-controlled NAVIGATE trial. Hepatology. 2026 May 1. doi: 10.1097/HEP.0000000000001774. Epub ahead of print. PMID: 42065864.

  8. Nephew LD, Cotter T, Singal A, Arab JP, Behari J, Tang Q, Gawrieh S, Tu W, Chalasani N. Neighborhood Disadvantage and Access to Liver Transplant Referral for Severe Alcohol-Associated Hepatitis. JAMA Netw Open. 2026 Mar 2;9(3):e262567. doi: 10.1001/jamanetworkopen.2026.2567. PMID: 41854611; PMCID: PMC13003376.

  9. Schwantes-An TH, Abreu MA, Neuschwander-Tetri BA, Wang J, Guo X, Tan J, Hegele RA, Davidson NO, Lotta L, Verweij N, Yates KP, Rotter JI, Chalasani N. Evaluation of Pathogenic Variants Associated With Monogenic Disorders of Dyslipidemia in Patients With Well Characterised MASLD. Liver Int. 2026 Feb;46(2):e70486. doi: 10.1111/liv.70486. PMID: 41514510; PMCID: PMC12789714.

  10. De A, Chalasani N, Duseja A. Biomarkers in Metabolic Dysfunction-Associated Steatotic Liver Disease. Gastroenterol Clin North Am. 2026 Mar;55(1):185-202. doi: 10.1016/j.gtc.2025.09.003. Epub 2025 Nov 7. PMID: 41581949.

  11. Vilar-Gomez E, Yates KP, Kleiner DE, Behling C, Cummings OW, Wilson LA, Liang T, Jarasvaraparn C, Loomba R, Schwimmer JB, Sanyal AJ, Hoofnagle J, Chalasani N. Genetic and non-genetic drivers of histological progression and regression in MASLD. J Hepatol. 2026 Mar;84(3):502-516. doi: 10.1016/j.jhep.2025.09.013. Epub 2025 Sep 24. PMID: 40998180; PMCID: PMC12495455.

  12. Vilar-Gomez E, Nephew L, Gawrieh S, Vuppalanchi R, Kettler C, Pike F, Tu W, Samala N, Liangpunsakul S, Chalasani N. Healthy eating and physical activity significantly lower sex-specific alcohol-attributable liver mortality in the United States. J Hepatol. 2026 Jan;84(1):18-34. doi: 10.1016/j.jhep.2025.06.033. Epub 2025 Aug 27. PMID: 40866123.

  13. Gawrieh S, Yao J, Guo X, Diehl AM, Rotter JI, Chalasani NP. Biological Age, PNPLA3, and Risk of Metabolic Dysfunction-associated Steatotic Liver Disease. Clin Gastroenterol Hepatol. 2026 Apr;24(4):1195-1197. doi: 10.1016/j.cgh.2025.08.014. Epub 2025 Aug 25. PMID: 40865626; PMCID: PMC13134670.

  14. Noureddin M, Rinella ME, Chalasani NP, Neff GW, Lucas KJ, Rodriguez ME, Rudraraju M, Patil R, Behling C, Burch M, Chan DC, Tillman EJ, Zari A, de Temple B, Shringarpure R, Jain M, Rolph T, Cheng A, Yale K. Efruxifermin in Compensated Liver Cirrhosis Caused by MASH. N Engl J Med. 2025 Jun 26;392(24):2413-2424. doi: 10.1056/NEJMoa2502242. Epub 2025 May 9. PMID: 40341827.

  15. Vuppalanchi R, Parvataneni S, Cihlar L, Longshore L, Orman E, Desai AP, Chalasani N. Inpatient Telehepatology at Community Hospitals: Expanding Access and Comanaging Complex Care. NEJM Catal Innov Care Deliv. 2025 Jun;6(6):10.1056/CAT.24.0412. doi: 10.1056/CAT.24.0412. Epub 2025 May 14. PMID: 41409718; PMCID: PMC12707029.

  16. Lammert C, Teal E, Ghabril M, Chalasani N. Incidence of Possible Drug-induced Liver Injury Due to Commonly Implicated Agents in the United States. Clin Gastroenterol Hepatol. 2025 May;23(6):1061-1062.e1. doi: 10.1016/j.cgh.2024.09.012. Epub 2024 Oct 22. PMID: 39447947.

  17. Le P, Tatar M, Rothberg MB, Wilson LA, Allende D, Diehl AM, Loomba R, Chalasani N, Neuschwander-Tetri BA, Kowdley K, Sanyal AJ, Tonascia J, Dasarathy S; NASH Clinical Research Network (CRN). Association of Components of Metabolic Syndrome and the Progression of Nonalcoholic Fatty Liver Disease. Am J Gastroenterol. 2026 Jan 1;121(1):159-170. doi: 10.14309/ajg.0000000000003455. Epub 2025 Mar 31. PMID: 40163040; PMCID: PMC12584972.

  18. Ghabril M, Vuppalanchi R, Chalasani N. Drug-Induced Liver Injury in Patients With Chronic Liver Disease. Liver Int. 2025 Mar;45(3):e70019. doi: 10.1111/liv.70019. PMID: 39927421; PMCID: PMC11808633.

  19. Chalasani N, Hayashi PH, Luffer-Atlas D, Regev A, Watkins PB. Assessment of liver injury potential of investigational medicines in drug development. Hepatology. 2025 Feb 25. doi: 10.1097/HEP.0000000000001281. Epub ahead of print. PMID: 39999469.

  20. Gopalakrishna H, Ghabril M, Gu J, Li YJ, Fontana RJ, Kleiner DE, Koh C, Chalasani N; Drug-Induced Liver Injury Network. Drug-induced Liver Injury Due to Medications for Alcohol Use Disorder: Results From the DILIN Prospective Study. J Addict Med. 2025 May-Jun 01;19(3):314-321. doi: 10.1097/ADM.0000000000001421. Epub 2024 Dec 9. PMID: 39651750; PMCID: PMC12133418.

  21. Chalasani N, Vilar-Gomez E, Loomba R, Yates KP, Diehl AM, Neuschwander-Tetri BA, Dasarathy S, Kowdley KV, Terrault N, Wilson LA, Tonascia J, Sanyal AJ. PNPLA3 rs738409, age, diabetes, sex, and advanced fibrosis jointly contribute to the risk of major adverse liver outcomes in metabolic dysfunction-associated steatotic liver disease. Hepatology. 2024 Nov 1;80(5):1212-1226. doi: 10.1097/HEP.0000000000000896. Epub 2024 Apr 23. PMID: 38652636; PMCID: PMC11798878.

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