43572-Wang, Xuepeng

Xuepeng Wang, PhD

Assistant Research Professor of Pediatrics

Phone
(317) 737-5295
Address
Wells R4
PNEB
IN
Indianapolis, IN
PubMed:

Bio

Xuepeng Wang, PhD, is an Assistant Research Professor of Pediatrics at Indiana University School of Medicine. His research focuses on hematopoietic stem cell biology, leukemia, and the molecular mechanisms that regulate normal and malignant hematopoiesis.

His work investigates how oxygen availability, metabolic regulation, and intracellular signaling pathways influence hematopoietic stem cell function, with the goal of improving stem cell transplantation outcomes. His research also explores the roles of signaling networks in leukemia cell biology, including their potential contributions to leukemic cell growth, survival, migration, and interactions with the bone marrow microenvironment.

Through these complementary research directions, he aims to advance our understanding of hematopoietic regulation and identify new strategies to improve stem cell transplantation and develop targeted approaches for hematologic malignancies.

Key Publications

1. Wang X, Srivastava S, Kanumuri R, et al. Ambient oxygen disrupts amino acid homeostasis and impairs human hematopoietic stem and progenitor cell engraftment. Blood. 2026. https://doi.org/10.1182/blood.2026034288

2. Wang X, Ramdas B, Kumar R, Zhang J, Kapur R. Suppression of Rho-associated kinase 1 (ROCK1) promotes human hematopoietic stem cell expansion by attenuating mitochondrial fission. Leukemia. 2025;39:2825–2829. https://doi.org/10.1038/s41375-025-02770-9

3. Wang X, Cooper S, Broxmeyer HE, Kapur R. Transient regulation of RNA methylation in human hematopoietic stem cells promotes their homing and engraftment. Leukemia. 2023;37:453–464. https://doi.org/10.1038/s41375-022-01761-4

4. Wang X, Cooper S, Broxmeyer HE, Kapur R. Nuclear translocation of TFE3 under hypoxia enhances the engraftment of human hematopoietic stem cells. Leukemia. 2022;36:2144–2148. https://doi.org/10.1038/s41375-022-01628-8

5. Wang X, Broxmeyer HE. DUSP16 is a regulator of human hematopoietic stem and progenitor cells and promotes their expansion ex vivo. Leukemia. 2021;35:1516–1520. https://doi.org/10.1038/s41375-020-01064-6

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