Shing Fai Chan, PhD
Assistant Research Professor of Radiology & Imaging Sciences
- Phone
- (317) 274-0918
- Address
-
KIC E371
CARD
IN
Indianapolis, IN - PubMed:
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Bio
Dr. Chan earned his BSc and MPHIL from Hong Kong University of Science and Technology and Ph.D. degree from the University of California, San Diego. Subsequently he completed postdoctoral training at Sanford-Burnham-Prebys Institute and Janssen: Pharmaceutical Companies of Johnson & Johnson in San Diego. He was recruited as Research Assistant Professor to Indiana University in 2019.
His current research at the Department of Radiology and Imaging Sciences is focused on investigating the time-dependent signaling cascade events following myocardial infarction using various cutting-edge tools employed in stem cell biology, molecular biology, and cardiovascular biology.
| Year | Degree | Institution |
|---|---|---|
| 2017 | Postdoctoral Training | Janssen Pharmaceutical Companies of Johnson & Johnson |
| 2013 | Postdoctoral Training | Sanford Burnham Prebys Discovery Institute |
| 2009 | PhD | University of California, San Diego |
| 1999 | MPHIL | Hong Kong University of Science and Technology |
| 1997 | BSC | Hong Kong University of Science and Technology |
- Research following Myocardial Infarction
- Stem Cell Biology
- Molecular Biology
- Cardiovascular Biology
Intramyocardial hemorrhage drives fatty degeneration of infarcted myocardium.
Cokic I; Chan SF; Guan X; Nair AR; Yang HJ; Liu T; Chen Y; Hernando D; Sykes J; Tang R; Butler J; Dohnalkova A; Kovarik L; Finney R; Kali A; Sharif B; Bouchard LS; Gupta R; Krishnam MS; Vora K; Tamarappoo B; Howarth AG; Kumar A; Francis J; Reeder SB; Wood JC; Prato FS; Dharmakumar R; Nature communications 2022 Oct 27
Cokic I; Chan SF; Guan X; Nair AR; Yang HJ; Liu T; Chen Y; Hernando D; Sykes J; Tang R; Butler J; Dohnalkova A; Kovarik L; Finney R; Kali A; Sharif B; Bouchard LS; Gupta R; Krishnam MS; Vora K; Tamarappoo B; Howarth AG; Kumar A; Francis J; Reeder SB; Wood JC; Prato FS; Dharmakumar R; Nature communications 2022 Oct 27
NitroSynapsin therapy for a mouse MEF2C haploinsufficiency model of human autism.
Tu S; Akhtar MW; Escorihuela RM; Amador-Arjona A; Swarup V; Parker J; Zaremba JD; Holland T; Bansal N; Holohan DR; Lopez K; Ryan SD; Chan SF; Yan L; Zhang X; Huang X; Sultan A; McKercher SR; Ambasudhan R; Xu H; Wang Y; Geschwind DH; Roberts AJ; Terskikh AV; Rissman RA; Masliah E; Lipton SA; Nakanishi N; Nature communications 2017 Nov 14
Tu S; Akhtar MW; Escorihuela RM; Amador-Arjona A; Swarup V; Parker J; Zaremba JD; Holland T; Bansal N; Holohan DR; Lopez K; Ryan SD; Chan SF; Yan L; Zhang X; Huang X; Sultan A; McKercher SR; Ambasudhan R; Xu H; Wang Y; Geschwind DH; Roberts AJ; Terskikh AV; Rissman RA; Masliah E; Lipton SA; Nakanishi N; Nature communications 2017 Nov 14
Transcriptional profiling of MEF2-regulated genes in human neural progenitor cells derived from embryonic stem cells.
Chan SF; Huang X; McKercher SR; Zaidi R; Okamoto SI; Nakanishi N; Lipton SA; Genomics data 2015 Mar 1
Chan SF; Huang X; McKercher SR; Zaidi R; Okamoto SI; Nakanishi N; Lipton SA; Genomics data 2015 Mar 1
ATM-dependent phosphorylation of MEF2D promotes neuronal survival after DNA damage.
Chan SF; Sances S; Brill LM; Okamoto S; Zaidi R; McKercher SR; Akhtar MW; Nakanishi N; Lipton SA; The Journal of neuroscience : the official journal of the Society for Neuroscience 2014 Mar 26
Chan SF; Sances S; Brill LM; Okamoto S; Zaidi R; McKercher SR; Akhtar MW; Nakanishi N; Lipton SA; The Journal of neuroscience : the official journal of the Society for Neuroscience 2014 Mar 26
S-nitrosylation-mediated redox transcriptional switch modulates neurogenesis and neuronal cell death.
Okamoto S; Nakamura T; Cieplak P; Chan SF; Kalashnikova E; Liao L; Saleem S; Han X; Clemente A; Nutter A; Sances S; Brechtel C; Haus D; Haun F; Sanz-Blasco S; Huang X; Li H; Zaremba JD; Cui J; Gu Z; Nikzad R; Harrop A; McKercher SR; Godzik A; Yates JR 3rd; Lipton SA; Cell reports 2014 Jul 4
Okamoto S; Nakamura T; Cieplak P; Chan SF; Kalashnikova E; Liao L; Saleem S; Han X; Clemente A; Nutter A; Sances S; Brechtel C; Haus D; Haun F; Sanz-Blasco S; Huang X; Li H; Zaremba JD; Cui J; Gu Z; Nikzad R; Harrop A; McKercher SR; Godzik A; Yates JR 3rd; Lipton SA; Cell reports 2014 Jul 4
Isogenic human iPSC Parkinson's model shows nitrosative stress-induced dysfunction in MEF2-PGC1a transcription.
Ryan SD; Dolatabadi N; Chan SF; Zhang X; Akhtar MW; Parker J; Soldner F; Sunico CR; Nagar S; Talantova M; Lee B; Lopez K; Nutter A; Shan B; Molokanova E; Zhang Y; Han X; Nakamura T; Masliah E; Yates JR 3rd; Nakanishi N; Andreyev AY; Okamoto S; Jaenisch R; Ambasudhan R; Lipton SA; Cell 2013 Nov 27
Ryan SD; Dolatabadi N; Chan SF; Zhang X; Akhtar MW; Parker J; Soldner F; Sunico CR; Nagar S; Talantova M; Lee B; Lopez K; Nutter A; Shan B; Molokanova E; Zhang Y; Han X; Nakamura T; Masliah E; Yates JR 3rd; Nakanishi N; Andreyev AY; Okamoto S; Jaenisch R; Ambasudhan R; Lipton SA; Cell 2013 Nov 27
S-Nitrosylation of parkin as a novel regulator of p53-mediated neuronal cell death in sporadic Parkinson's disease.
Sunico CR; Nakamura T; Rockenstein E; Mante M; Adame A; Chan SF; Newmeyer TF; Masliah E; Nakanishi N; Lipton SA; Molecular neurodegeneration 2013 Aug 28
Sunico CR; Nakamura T; Rockenstein E; Mante M; Adame A; Chan SF; Newmeyer TF; Masliah E; Nakanishi N; Lipton SA; Molecular neurodegeneration 2013 Aug 28
MEF2C enhances dopaminergic neuron differentiation of human embryonic stem cells in a parkinsonian rat model.
Cho EG; Zaremba JD; McKercher SR; Talantova M; Tu S; Masliah E; Chan SF; Nakanishi N; Terskikh A; Lipton SA; PloS one 2011 Aug 25
Cho EG; Zaremba JD; McKercher SR; Talantova M; Tu S; Masliah E; Chan SF; Nakanishi N; Terskikh A; Lipton SA; PloS one 2011 Aug 25
Association of the small GTPase Rheb with the NMDA receptor subunit NR3A.
Sucher NJ; Yu E; Chan SF; Miri M; Lee BJ; Xiao B; Worley PF; Jensen FE; Neuro-Signals 2010 Dec 7
Sucher NJ; Yu E; Chan SF; Miri M; Lee BJ; Xiao B; Worley PF; Jensen FE; Neuro-Signals 2010 Dec 7
The retroviral oncoprotein Tax targets the coiled-coil centrosomal protein TAX1BP2 to induce centrosome overduplication.
Ching YP; Chan SF; Jeang KT; Jin DY; Nature cell biology 2006 Jun 11
Ching YP; Chan SF; Jeang KT; Jin DY; Nature cell biology 2006 Jun 11
Mitochondrial targeting of growth suppressor protein DLC2 through the START domain.
Ng DC; Chan SF; Kok KH; Yam JW; Ching YP; Ng IO; Jin DY; FEBS letters 2005 Dec 9
Ng DC; Chan SF; Kok KH; Yam JW; Ching YP; Ng IO; Jin DY; FEBS letters 2005 Dec 9
Deleted in liver cancer (DLC) 2 encodes a RhoGAP protein with growth suppressor function and is underexpressed in hepatocellular carcinoma.
Ching YP; Wong CM; Chan SF; Leung TH; Ng DC; Jin DY; Ng IO; The Journal of biological chemistry 2003 Jan 16
Ching YP; Wong CM; Chan SF; Leung TH; Ng DC; Jin DY; Ng IO; The Journal of biological chemistry 2003 Jan 16
Temporal and regional expression of NMDA receptor subunit NR3A in the mammalian brain.
Wong HK; Liu XB; Matos MF; Chan SF; Pérez-Otaño I; Boysen M; Cui J; Nakanishi N; Trimmer JS; Jones EG; Lipton SA; Sucher NJ; The Journal of comparative neurology 2002 Sep 2
Wong HK; Liu XB; Matos MF; Chan SF; Pérez-Otaño I; Boysen M; Cui J; Nakanishi N; Trimmer JS; Jones EG; Lipton SA; Sucher NJ; The Journal of comparative neurology 2002 Sep 2
Characterization and comparison of the NR3A subunit of the NMDA receptor in recombinant systems and primary cortical neurons.
Sasaki YF; Rothe T; Premkumar LS; Das S; Cui J; Talantova MV; Wong HK; Gong X; Chan SF; Zhang D; Nakanishi N; Sucher NJ; Lipton SA; Journal of neurophysiology 2002 Apr
Sasaki YF; Rothe T; Premkumar LS; Das S; Cui J; Talantova MV; Wong HK; Gong X; Chan SF; Zhang D; Nakanishi N; Sucher NJ; Lipton SA; Journal of neurophysiology 2002 Apr
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