Kathleen Overholt, MD

Key Publications

Peer Reviewed Publications:

1.    Kathleen M Overholt, T. Guinipero, N. Heerema, M. Loken, and S. Kahwash. Promyelocytic Leukemia with No Retinoic Acid Receptor Alpha Abnormality but with RUNX1T1 Insertion to Chromosome 7q: A Classification and Management Dilemma. Case Reports in Hematology. Volume 2015 (2015), Article ID 412016

 2.    Satoru Otsuru; Kathleen M Overholt; Timothy S. Olson; Ted J Hofmann; Adam J Guess; Victoria M Velazquez; Takashi Kaito; Massimo Dominici; Edwin M Horwitz. Hematopoietic Derived Cells Do Not Contribute To Osteogenesis As Osteoblasts. Bone. 2016; 94:2017, 1–9

3.    Kathleen M Overholt, Melissa J. Rose, Sarita Joshi, Gail E. Herman, Rajinder Bajwa, Rolla Abu-Arja, Hemalatha G. Rangarajan, Edwin M. Horwitz. Hematopoietic Cell Transplantation for a Child with OSTM1-Osteopetrosis.  Blood Advances 2017; 1(4):279-281

4.    Adam J. Guess, Beth Daneault,, Rongzhang Wong, Hillary Bradbury, Krista M D La Perle, James Fitch, Sheri L Hedrick, Elizabeth Hamelberg, Caroline Astbury, Peter White, Kathleen [Overholt], Hemalatha Rangarajan, Rolla Abu-Arja, Steven M Devine, Satoru Otsuru, Massimo Dominici, Lynn O’Donnell, Edwin M Horwitz. Safety Profile of Good Manufacturing Practice Manufactured Interferon c Primed Mesenchymal Stem/Stromal Cells for Clinical Trials. Stem Cells Transl Med. 2017 Oct; 6(10):1868-1879

5.    Kathleen M. Overholt, Satoru Otsuru, Timothy S. Olson, Adam J. Guess, Victoria M. Velazquez, Laura Desbourdes, Massimo Dominici, and Edwin M. Horwitz. Identification of a Murine CD45^neg F4/80^lo HSC-derived Marrow Endosteal Cell Associated with Donor Stem Cell Engraftment. Blood Advances 2017; 1(27): 2667-2678

6.    Rachael F. Grace, Robert J. Klaassen, Kristin A. Shimano, Michele P. Lambert, Amanda Grimes, James B. Bussel, Vicky R. Breakey, Yves D. Pastore, Vandy Black, Kathleen Overholt, Peter W. Forbes, Cindy Neunert. Fatigue in Children and Adolescents with Immune Thrombocytopenia. British Journal of Haemotology, 2020, 191, 98–106. https://doi.org/10.1111/bjh.16751

7.    Tyler S. Severance, Mahvish Q. Rahim, James French II, Richelle M. Baker, Andrew Shriner, Alka Khaitan, Kathleen M. Overholt. COVID-19 and Hereditary Spherocytosis:  A Recipe for Hemolysis. Pediatric Blood and Cancer 2020; e28548. DOI: 10.1002/pbc.28548

 8.    Suheyla Hasgur, Luara Desbourdes, Theresa Relation, Kathleen Overholt, Joseph Stanek, Adam Guess, Minjin Yu, Pratik Patel, Linda Roback, Massimo Dominici, Satoru Otsuru, Edwin M. Horwitz. Splenic Macrophage Phagocytosis of Intravenously Infused MSCs Attenuates Tumor Localization. Cytotherapy. 2021 May;23(5):411-422. doi: 10.1016/j.jcyt.2020.04.102.

 9.    Kristin Shimano, Anupama Narla, Melissa J. Rose, Nicholas J. Gloude, Steven W. Allen, Katie Bergstrom, Larisa Broglie, Beth A. Carella, Paul Castillo, Jill L. O. de Jong, Yigal Dror, Amy E. Geddis, James N. Huang, Bonnie W. Lau, Catherine McGuinn, Taizo A. Nakano, Kathleen Overholt, Jennifer A. Rothman, Anjali Sharathkumar, Evan Shereck, Adrianna Vlachos, Timothy S. Olson, Alison A. Bertuch, Marcin Wlodarski, Akiko Shimamura, and Jessica Boklan. “Diagnostic work-up for severe aplastic anemia in children: Consensus of the North American Pediatric Aplastic Anemia Consortium (NAPAAC).”  Am J Hematol. 2021 Nov 1;96(11):1491-1504. doi: 10.1002/ajh.26310.

10.  Severance TS, Njuguna F, Olbara G, Kugo M, Langat S, Mostert S, Klootwijk L, Skiles J, Coven SL, Overholt KM, Kaspers G, Vik TA. An evaluation of the disparities affecting the underdiagnosis of pediatric cancer in Western Kenya. Pediatr Blood Cancer. 2022 Oct;69(10):e29768. doi: 10.1002/pbc.29768. Epub 2022 May 20. PMID: 35593641.

 11.  Arand A, Overholt K, Jacob SA, Belsky JA. Epstein-Barr Virus-Positive Hemophagocytic Lymphohistiocytosis Following COVID-19 Vaccination in a Pediatric Patient. Pediatr Blood Cancer. 2023 May;70(5):e30189. doi: 10.1002/pbc.30189. Epub 2023 Jan 11. PMID: 36632038

12.  Mahvish Q. Rahim, April Rahrig, Kathleen Overholt, Erin Conboy, Amanda June Saraf. A SAMD9 Familial Variant of associated with an Aggressive Case of Pediatric MDS. Accepted by Cold Spring Harbor Molecular Case Studies 03/2023

13.  Kristin A. Shimano, Jennifer A. Rothman, Steven W. Allen, Paul Castillo, Jill L. O. de Jong, Yigal Dror, Amy E. Geddis, Bonnie W. Lau, Catherine McGuinn, Anupama Narla, Kathleen Overholt, Maria Pereda Ginocchio, Anjali Sharathkumar, Ghadir Sasa, Taizo A. Nakano, Kasiani Myers, Nicholas J. Gloude, Larisa Broglie, and Jessica Boklan. Treatment of Newly Diagnosed Severe Aplastic Anemia in Children: Evidence-based Recommendations.  Pediatr Blood Cancer. 2024 Aug;71(8):e31070. doi: 10.1002/pbc.31070.

14.  Kristin A. Shimano, Ghadir Sasa, Larisa Broglie, Nicholas J. Gloude, Kasiani Myers, Taizo A. Nakano, Anjali Sharathkumar, Jennifer A. Rothman, Maria Pereda Ginocchio, Kathleen Overholt, Anupama Narla, Catherine McGuinn, Bonnie W. Lau, Amy E. Geddis, Yigal Dror, Jill L. O. de Jong, Paul Castillo, Steven W. Allen, and Jessica Boklan. Treatment of Relapsed/Refractory Severe Aplastic Anemia in Children: Evidence-based Recommendations. Pediatr Blood Cancer. 2024 Aug;71(8):e31075. doi: 10.1002/pbc.31075.

15. Akiko Shimamura, Alexey Maschan, Carolyn Bennett, Sujith Samarasinghe, Jason E. Farrar, Chi-kong Li, Nongnuch Sirachainan, Bunchoo Pongtanakul, Patcharee Komvilaisak, Ludmila Zubarovskaya, Jennifer A. Rothman, Kelly Walkovich, Taizo A. Nakano, Alison A. Bertuch, Anabela Ferrao, Rukhmi Bhat, Rabi Hanna, Kathleen Overholt, Jessica Boklan, Tze Fang Wong, Qinxia Wang, Patrick Urban, Brigitte Strahm, Winfred Wang, Adrianna Vlachos, David A. Williams. Eltrombopag in combination with immunosuppressive therapy in pediatric severe aplastic anemia: phase 2 ESCALATE trial. Blood Advances.