Sheng Liu, PhD

Key Publications

Zhu, Yini; Zhao, Yun; Wen, Jiling; Liu, Sheng; Huang, Tianhe; Hatial, Ishita; Peng, Xiaoxia; Al Janabi, Hawraa; Huang, Gang; Mittlesteadt, Jackson; Targeting the chromatin effector Pygo2 promotes cytotoxic T cell responses and overcomes immunotherapy resistance in prostate cancer,Science Immunology,8,81,2023

Mijit, Mahmut*; Liu, Sheng*; Sishtla, Kamakshi; Hartman, Gabriella D; Wan, Jun; Corson, Timothy W; Kelley, Mark R; Identification of novel pathways regulated by APE1/Ref-1 in human retinal endothelial cells,International Journal of Molecular Sciences,24,2,1101,2023

Dausinas Ni, Paige; Hartman, Melissa; Slack, Jacob; Basile, Christopher; Liu, Sheng; Wan, Jun; O'Leary, Heather A; Novel differential calcium regulation of hematopoietic stem and progenitor cells under physiological low oxygen conditions,Journal of Cellular Physiology,2023.

Pasupuleti, Santhosh Kumar; Chao, Karen; Ramdas, Baskar; Kanumuri, Rahul; Palam, Lakshmi Reddy; Liu, Sheng; Wan, Jun; Annesley, Colleen; Loh, Mignon L; Stieglitz, Elliot; Potential clinical use of azacitidine and MEK inhibitor combination therapy in PTPN11-mutated juvenile myelomonocytic leukemia,Molecular Therapy,31,4,986-1001,2023.

Khatpe, Aditi S; Dirks, Rebecca; Bhat-Nakshatri, Poornima; Mang,  Henry; Batic, Katie; Swiezy, Sarah; Olson, Jacob; Rao, Xi; Wang, Yue; Tanaka, Hiromi; Liu, Sheng; Wan, Jun; Chen, Duojiao; Liu, Yunlong; Fang, Fang; Althouse, Sandra; Hulsey, Emily; Granatir, Maggie M; Addison, Rebekah; Temm, Constance J; Sandusky, George; Lee-Gosselin, Audrey; Nephew, Kenneth; Miller, Kathy D; Nakshatri, Harikrishna; TONSL Is an Immortalizing Oncogene and a Therapeutic Target in Breast Cancer,Cancer Research,83,8,1345-1360,2023

Zhao, Ting; Liu, Sheng; Hanna, Nasser H; Jalal, Shadia; Ding, Xinchun; Wan, Jun; Yan, Cong; Du, Hong; LAL deficiency induced myeloid-derived suppressor cells as targets and biomarkers for lung cancer,Journal for Immunotherapy of Cancer,11,3,,2023.

Zhao, Yin Quan; Jin, Hong Ri; Kim, Daeho; Jung, Sung Han; Liu, Sheng; Wan, Jun; Lo, Ho-Yin; Fu, Xue Qi; Wang, Quan; Hao, Chunhai; SUMO1 degrader induces ER stress and ROS accumulation through deSUMOylation of TCF4 and inhibition of its transcription of StarD7 in colon cancer,Molecular Carcinogenesis,2023.

Zhao, Yun; Liu, Zhongshun; Liu, Guoqiang; Zhang, Yuting; Liu, Sheng; Gan, Dailin; Chang, Wennan; Peng, Xiaoxia; Sung, Eun Suh; Gilbert, Keegan; Neutrophils resist ferroptosis and promote breast cancer metastasis through aconitate decarboxylase 1,Cell Metabolism,35,10,1688-1703. e10,2023.

Chen, Duojiao*; Liu, Sheng*; Chu, Xiaona; Reiter, Jill; Gao, Hongyu; McGuire, Patrick; Yu, Xuhong; Xuei, Xiaoling; Liu, Yichen; Wan, Jun; Osteogenic Differentiation Potential of Mesenchymal Stem Cells Using Single Cell Multiomic Analysis, Genes,14,10,1871,2023.

Heller, Daniel T; Kolson, Douglas R; Brandebura, Ashley N; Amick, Emily M; Wan, Jun; Ramadan, Jad; Holcomb, Paul S; Liu, Sheng; Deerinck, Thomas J; Ellisman, Mark H; Astrocyte ensheathment of calyx-forming axons of the auditory brainstem precedes accelerated expression of myelin genes and myelination by oligodendrocytes, Journal of Comparative Neurology,2023.

Mahmut Mijit*, Sheng Liu*, Kamakshi Sishtla, Gabriella D Hartman, Jun Wan, Timothy W. Corson, Mark R. Kelley. Identification of novel pathways regulated by APE1/Ref-1 in human retinal endothelial cells. International Journal of Molecular Sciences. Accepted.

Kanhaiya Singh, Yashika Rustagi, Ahmed S Abouhashem, Saba Tabasum, Priyanka Verma, Edward Hernandez, Durba Pal, Dolly K Khona, Sujit K Mohanty, Manishekhar Kumar, Rajneesh Srivastava, Poornachander R Guda, Sumit S Verma, Sanskruti Mahajan, Jackson A Killian, Logan A Walker, Subhadip Ghatak, Shomita S Mathew-Steiner, Kristen E Wanczyk, Sheng Liu, Jun Wan, Pearlly Yan, Ralf Bundschuh, Savita Khanna, Gayle M Gordillo, Michael P Murphy, Sashwati Roy, Chandan K Sen. Genome-wide DNA hypermethylation opposes healing in patients with chronic wounds by impairing epithelial-mesenchymal transition. The Journal of clinical investigation. 132(17). 2022

Ting Zhao, Sheng Liu, Xinchun Ding, Erica M Johnson, Nasser H Hanna, Kanhaiya Singh, Chandan K Sen, Jun Wan, Hong Du, Cong Yan. Lysosomal acid lipase, CSF1R and PD-L1 determine functions of CD11c+ myeloid-derived suppressor cells. JCI insight. 2022

Yashika Rustagi, Ahmed S Abouhashem, Priyanka Verma, Sumit S Verma, Edward Hernandez, Sheng Liu, Manishekhar Kumar, Poornachander R Guda, Rajneesh Srivastava, Sujit K Mohanty, Sedat Kacar, Sanskruti Mahajan, Kristen E Wanczyk, Savita Khanna, Michael P Murphy, Gayle M Gordillo, Sashwati Roy, Jun Wan, Chandan K Sen, Kanhaiya Singh. Endothelial Phospholipase Cγ2 Improves Outcomes of Diabetic Ischemic Limb Rescue Following VEGF Therapy. Diabetes. 71(5):1149-1165. 2022

Jake L Owens, Elena Beketova, Sheng Liu, Qi Shen, Jogendra Singh Pawar, Andrew M Asberry, Jie Yang, Xuehong Deng, Bennett D Elzey, Timothy L Ratliff, Liang Cheng, Richard Choo, Deborah E Citrin, Thomas J Polascik, Bangchen Wang, Jiaoti Huang, Chenglong Li, Jun Wan, Chang-Deng Hu. Targeting Protein Arginine Methyltransferase 5 Suppresses Radiation-induced Neuroendocrine Differentiation and Sensitizes Prostate Cancer Cells to Radiation. Molecular Cancer Therapeutics. 21(3):448-459. 2022

Alan Y Hsu, Tianqi Wang, Ramizah Syahirah, Sheng Liu, Kailing Li, Weiwei Zhang, Jiao Wang, Ziming Cao, Simon Tian, Sandro Matosevic, Christopher J Staiger, Jun Wan, Qing Deng. RORA regulates neutrophil migration and activation in zebrafish. Frontiers in Immunology. 13. 2022

Kailing Li, Audrey KY Wang, Sheng Liu, Shuyi Fang, Alex Z Lu, Jikui Shen, Lei Yang, Chang-Deng Hu, Kai Yang, Jun Wan. Advanced Functions Embedded in the Second Version of Database, Global Evaluation of SARS-CoV-2/hCoV-19 Sequences 2. Frontiers in Medicine. 9. 2022

X. Zhong, A. Narasimhan, L. M Silverman, A. R Young, S. Shahda, S. Liu, J. Wan, Y. Liu, L. G Koniaris, T. A Zimmers. Sex specificity of pancreatic cancer cachexia phenotypes, mechanisms, and treatment in mice and humans: role of Activin. Journal of Cachexia, Sarcopenia and Muscle. 13(4):2146-2161. 2022

S. Fang, S. Liu, D. Yang, L. Yang, C. Hu, J. Wan. Decoding regulatory associations of G-quadruplex with epigenetic and transcriptomic functional components. Front Genet 2022;13:957023

J. Du, Q. Wang, S. Yang, S. Chen, Y. Fu, S. Spath, P. Domeier, D. Hagin, S. Anover-Sombke, M. Haouili, S. Liu, J. Wan, L. Han, J. Liu, L. Yang, N. Sangani, Y. Li, X. Lu, S. C. Janga, M. H Kaplan , T. R Torgerson, S. F Ziegler, B. Zhou. FOXP3 exon 2 controls T reg stability and autoimmunity. Sci Immunol. 7(72). 2022

Z. Zhou, K. Van der Jeught, Y. Fang, T. Yu, Y. Li, Z. Ao, S. Liu, L. Zhang, Y. Yang, H. Eyvani, M.L Cox, X. Wang, X. He, G. Ji, B. P Schneider, F. Guo, J. Wan, X. Zhang, X. Lu. An organoid-based screen for epigenetic inhibitors that stimulate antigen presentation and potentiate T-cell-mediated cytotoxicity. Nature biomedical engineering. 2021. 5(11)1320-1335.

W. Zhao, L. Jiang, T. Fang, F. Fang, Y. Liu, Y. Zhao, Y. You, H. Zhou, X. Su, J. Wang, S. Liu, Y. Chen, J. Wan, X. Huang. β-Lapachone Selectively Kills Hepatocellular Carcinoma Cells by Targeting NQO1 to Induce Extensive DNA Damage and PARP1 Hyperactivation. Frontiers in Oncology. 2021. 

S. Fang*, S.Liu*, J. Shen, A. Lu, A. Wang, Y. Zhang, K. Li, J. Liu, L. Yang, C. Hu, J. Wan. Updated SARS-CoV-2 Single Nucleotide Variants and Mortality Association. J Med Virol. 2021 Dec;93(12):6525-6534

C. Xu, Y. Fu, S. Liu, J. Trittipo, X. Lu, S. Sun, R. Qi, H. Du, C. Yan, C. Zhang, M. Kaplan, K. Yang. BATF regulates Treg-cell functional specification and fitness of triglyceride metabolism in restraining allergic responses. The Journal of Immunology. 2021. 206(9);2088-2100.

C. Zhu, M. Huang, H. Kim, K. Chowdhury, J. Gao, S. Liu, J. Wan, L. Wei. X. Dong. SIRT6 controls hepatic lipogenesis by suppressing LXR, ChREBP, and SREBP1. BBA – Molecular Basis of Disease. Accepted.

Y. Chen, S. Fang, Q. Ding, R. Jiang, J. He, Q. Wang, Y. Jin, X. Huang, S. Liu, M. Captiano, T. Trinh, Y. Teng, Q. Meng, J. Wan, H. Broxmeyer, B. Guo. ADGRG1 enriches for functional human hematopoietic stem cells following ex vivo expansion-induced mitochondrial oxidative stress. J. Clin. Invest. 2021;131(20):e148329.

J. Liu, S. Liu, L. Han, Y. Sheng, Y. Zhang, I. Kim, J. Wan, L. Yang. LncRNA HBL1 is required for genome-wide PRC2 occupancy and function in cardiogenesis from human pluripotent stem cells. Development. 2021. 148(13):dev199628.

N. Morral, S. Liu, A. M.Conteh, X. Chu, Y. Wang, X. C. Dong, Y. Liu, A. K. Linnemann, J. Wan. Aberrant gene expression induced by a high fat diet is linked to H3K9 acetylation in the promoter-proximal region. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 1864:3. 2021

P. Bhat-Nakshatri, H. Gao, S. Liu, P. C. McGuire, X. Xuei, J. Wan, Y. Liu, S. K. Althouse, A. Colter, G. Sandusky, A. M. Storniolo, and H.  Nakshatri. A single cell atlas of the healthy breast tissues reveal clinically relevant clusters of breast epithelial cells. Cell Reports Medicine. 2021. 2(3); 100219.

S. Fang, K. Li, J. Shen, S. Liu, J. Liu, L. Yang, C-D Hu, J. Wan. GESS: a database of global evaluation of SARS-CoV-2/hCoV-19 sequences. Nucleic acids research. 49:D1, D706-D714. 2020.

J. Liu, S. Liu, H. Gao, L. Han, X. Chu, Y. Sheng, W. Shou, Y. Wang, Y. Liu, J Wan, L. Yang. Genome-wide studies reveal the essential and opposite roles of ARID1A in controlling human cardiogenesis and neurogenesis from pluripotent stem cells. Genome Biology. 21, 169. 2020.

E. Beketova, S. Fang, J. L. Owens, S. Liu, X. Chen, Q. Zhang, A. M. Asberry, X. Deng, J. Malola, J. Huang, C. Li, R. Pili, B. D. Elzey, T. L. Ratliff, J. Wan and C-D  Hu. Protein Arginine Methyltransferase 5 Promotes pICln-Dependent Androgen Receptor Transcription in Castration-Resistant Prostate Cancer. Cancer Research. 80:4904–17. 2020.

S. Liu*, J. Shen*, S. Fang, K. Li, J. Liu, L. Yang, C. Hu, J. Wan. Genetic Spectrum and Distinct Evolution Patterns of SARS-CoV-2. Front. Microbiol. 11:593548. 2020.

S. Dey, S. Liu, T. D Factora, S. Taleb, P. Riverahernandez, L. Udari, X. Zhong, J. Wan, J. Kota. Global targetome analysis reveals critical role of miR-29a in pancreatic stellate cell mediated regulation of PDAC tumor microenvironment. BMC Cancer. Accepted.

J. Wen, G. Huang, S. Liu, J. Wan, X. Wang, Y. Zhu, W. Kaliney, C. Zhang, L. Cheng, X. Wen, X. Lu. Polymorphonuclear MDSCs Are Enriched in the Stroma and Expanded in Metastases of Prostate Cancer. J Pathol Clin Res. 6(3):171-177. 2020.

D. Xu, D. Zhou, K. Bum-Erdene, B. J. Bailey, K. Sishtla, S. Liu, J. Wan, U. K. Aryal, J. A. Lee, C. D. Wells, M. L. Fishel, T. W. Corson, K. E. Pollok*, and S. O. Meroueh. Phenotypic Screening of Chemical Libraries Enriched by Molecular Docking to Multiple Targets Selected from Glioblastoma Genomic Data. ACS Chem. Biol. 15:6, 1424–1444. 2020.

D. Xu, M. Yang, M. Capitano, B. Guo, S. Liu, J. Wan, H. Broxmeyer, and X. Huang. Pharmacological activation of nitric oxide signaling promotes human hematopoietic stem cell homing and engraftment. Leukemia. 35, pages229–234. 2020.

J. L. Owens, E. Beketova*, S. Liu*, S.L. Tinsley, A. M. Asberry, X. Deng, J. Huang, C. Li, J. Wan, and C. Hu. PRMT5 cooperates with pICln to function as a master epigenetic activator of DNA double-strand break repair genes. iScience. 23:1, 2020. Co-second author

S. Dey, J. Kwon, S. Liu, T. Zimmers, J. Wan, J. kota. miR-29a is repressed by MYC in pancreatic cancer and its restoration exhibits anti-tumorigenicity via downregulation of LOXL2. Molecular Cancer Research. 18:2. 2020.

B. Khambu, H. Hong, S. Liu, G. Liu, X. Chen, Z. Dong, J. Wan, X-M Yin. The HMGB1-RAGE axis modulates the growth of autophagy-deficient hepatic tumors. Cell death & disease. 11:5, 1-15. 2020

A. Hsu, D. Wang, S. Liu, J. Lu, R. Syahirah, D. A. Bennin, A. Huttenlocher, D. M. Umulis, J. Wan, and Q. Deng. Phenotypical microRNA screen reveals a noncanonical role of CDK2 in regulating neutrophil migration. PNAS. 116 (37) 18561-18570. 2019.

J. Wan, H. Dai, X. Zhang, S. Liu, Y. Lin, A. Somani, J. Xie, J. Han.  Distinct Transcriptomic Landscapes of Cutaneous Basal Cell Carcinomas and Squamous Cell Carcinomas. Genes & Diseases. 2019. Accepted.

M. Hu, D. Kim, S. Liu, D. J Zack, S. Blackshaw, J. Qian.  PanoView: An iterative clustering for single-cell RNA sequencing data. PLOS Computational Biology. 15(8): e1007040. 2019.

A. Hsu, S. Liu, R. Syahirah, K. Brasseale, J. Wan, Q. Deng. Inducible overexpression of zebrafish microRNA-722 suppresses chemotaxis of human neutrophil like cells. Molecular Immunology. 112:206-214. 2019.

Y. Chen, C. Yao, Y. Teng, R. Jiang, X. Huang, S. Liu, J. Wan, H. Broxmeyer, and B. Guo. Phorbol ester induced ex vivo expansion of rigorously-defined phenotypic but not functional human cord blood hematopoietic stem cells: a cautionary tale demonstrating that phenotype does not always recapitulate stem cell function. Nature leukemia. 33(12):2962-2966. 2019

C. Zibetti, S. Liu, J. Wan, J. Qian, S. Blackshaw. Epigenomic profiling of retinal progenitors reveals LHX2 is required for developmental regulation of open chromatin. Communications Biology. 2:142. 2019.

J. Xu, Y. Liu , Y. Li , H. Wang , S. Stewart , K. Van der Jeught , P. Agarwal , Y. Zhang , S. Liu , G. Zhao , J. Wan , X. Lu, X. He. Precise targeting of POLR2A as a therapeutic strategy for human triple negative breast cancer. Nature nanotechnology. 14, pages388–397. 2019.

A. Shinde, S. Hardy, D. Kim, S. S. Akhand, M. Jolly, W. Wang, J. Anderson, R. Khodadadi, W. Brown, J. George, S. Liu, J. Wan, H. Levine, C. Willey, C. Krusemark, R. Geahlen, and M. Wendt. Spleen tyrosine kinase-mediated autophagy is required for epithelial-mesenchymal plasticity and breast cancer metastasis. Cancer Research. 79(8):1831-1843. 2019.

A. Cerra-Francoa*, S. Liu*, M. Azar, K. Shiue, S. Freije, J. Hintona, C. Deiga, N. C. Estabrook III, S. G. Ellswortha, K. Huang, K. Diabe, M. P. Langer, R. Zellars, F. M. Konga, J. Wan, and T. Lautenschlaeger. Predictors of Nodal and Metastatic Failure in Early Stage Non-Small Cell Lung Cancer after Stereotactic Body Radiation Therapy. 20(3):186-193.e3. co-first author