Sheng Liu, PhD

Bio

Dr. Sheng Liu is an Assistant Scientist in the Department of Medical and Molecular Genetics (MMGE), at Indiana University School of Medicine. He is the project manager at Indiana University's Collaborative Core for Cancer Bioinformatics (C3B) shared by Indiana University Simon Comprehensive Cancer Center (ISC) and NCI-designated cancer center, Purdue University Center for Cancer Research (PUCCR).

Dr. Liu received his Ph.D. degree in computer science from the University of Mississippi. He completed his postdoctoral training with a specialized focus in computational modeling of gene regulation in mammalian systems at Johns Hopkins University School of Medicine. His research interests include machine learning, bioinformatics, and their applications to biomedical problems.

Key Publications

Zhu, Yini; Zhao, Yun; Wen, Jiling; Liu, Sheng; Huang, Tianhe; Hatial, Ishita; Peng, Xiaoxia; Al Janabi, Hawraa; Huang, Gang; Mittlesteadt, Jackson; Targeting the chromatin effector Pygo2 promotes cytotoxic T cell responses and overcomes immunotherapy resistance in prostate cancer,Science Immunology,8,81,2023

Mijit, Mahmut*; Liu, Sheng*; Sishtla, Kamakshi; Hartman, Gabriella D; Wan, Jun; Corson, Timothy W; Kelley, Mark R; Identification of novel pathways regulated by APE1/Ref-1 in human retinal endothelial cells,International Journal of Molecular Sciences,24,2,1101,2023

Dausinas Ni, Paige; Hartman, Melissa; Slack, Jacob; Basile, Christopher; Liu, Sheng; Wan, Jun; O'Leary, Heather A; Novel differential calcium regulation of hematopoietic stem and progenitor cells under physiological low oxygen conditions,Journal of Cellular Physiology,2023.

Pasupuleti, Santhosh Kumar; Chao, Karen; Ramdas, Baskar; Kanumuri, Rahul; Palam, Lakshmi Reddy; Liu, Sheng; Wan, Jun; Annesley, Colleen; Loh, Mignon L; Stieglitz, Elliot; Potential clinical use of azacitidine and MEK inhibitor combination therapy in PTPN11-mutated juvenile myelomonocytic leukemia,Molecular Therapy,31,4,986-1001,2023.

Khatpe, Aditi S; Dirks, Rebecca; Bhat-Nakshatri, Poornima; Mang,  Henry; Batic, Katie; Swiezy, Sarah; Olson, Jacob; Rao, Xi; Wang, Yue; Tanaka, Hiromi; Liu, Sheng; Wan, Jun; Chen, Duojiao; Liu, Yunlong; Fang, Fang; Althouse, Sandra; Hulsey, Emily; Granatir, Maggie M; Addison, Rebekah; Temm, Constance J; Sandusky, George; Lee-Gosselin, Audrey; Nephew, Kenneth; Miller, Kathy D; Nakshatri, Harikrishna; TONSL Is an Immortalizing Oncogene and a Therapeutic Target in Breast Cancer,Cancer Research,83,8,1345-1360,2023

Zhao, Ting; Liu, Sheng; Hanna, Nasser H; Jalal, Shadia; Ding, Xinchun; Wan, Jun; Yan, Cong; Du, Hong; LAL deficiency induced myeloid-derived suppressor cells as targets and biomarkers for lung cancer,Journal for Immunotherapy of Cancer,11,3,,2023.

Zhao, Yin Quan; Jin, Hong Ri; Kim, Daeho; Jung, Sung Han; Liu, Sheng; Wan, Jun; Lo, Ho-Yin; Fu, Xue Qi; Wang, Quan; Hao, Chunhai; SUMO1 degrader induces ER stress and ROS accumulation through deSUMOylation of TCF4 and inhibition of its transcription of StarD7 in colon cancer,Molecular Carcinogenesis,2023.

Zhao, Yun; Liu, Zhongshun; Liu, Guoqiang; Zhang, Yuting; Liu, Sheng; Gan, Dailin; Chang, Wennan; Peng, Xiaoxia; Sung, Eun Suh; Gilbert, Keegan; Neutrophils resist ferroptosis and promote breast cancer metastasis through aconitate decarboxylase 1,Cell Metabolism,35,10,1688-1703. e10,2023.

Chen, Duojiao*; Liu, Sheng*; Chu, Xiaona; Reiter, Jill; Gao, Hongyu; McGuire, Patrick; Yu, Xuhong; Xuei, Xiaoling; Liu, Yichen; Wan, Jun; Osteogenic Differentiation Potential of Mesenchymal Stem Cells Using Single Cell Multiomic Analysis, Genes,14,10,1871,2023.

Heller, Daniel T; Kolson, Douglas R; Brandebura, Ashley N; Amick, Emily M; Wan, Jun; Ramadan, Jad; Holcomb, Paul S; Liu, Sheng; Deerinck, Thomas J; Ellisman, Mark H; Astrocyte ensheathment of calyx-forming axons of the auditory brainstem precedes accelerated expression of myelin genes and myelination by oligodendrocytes, Journal of Comparative Neurology,2023.

Mahmut Mijit*, Sheng Liu*, Kamakshi Sishtla, Gabriella D Hartman, Jun Wan, Timothy W. Corson, Mark R. Kelley. Identification of novel pathways regulated by APE1/Ref-1 in human retinal endothelial cells. International Journal of Molecular Sciences. Accepted.

Kanhaiya Singh, Yashika Rustagi, Ahmed S Abouhashem, Saba Tabasum, Priyanka Verma, Edward Hernandez, Durba Pal, Dolly K Khona, Sujit K Mohanty, Manishekhar Kumar, Rajneesh Srivastava, Poornachander R Guda, Sumit S Verma, Sanskruti Mahajan, Jackson A Killian, Logan A Walker, Subhadip Ghatak, Shomita S Mathew-Steiner, Kristen E Wanczyk, Sheng Liu, Jun Wan, Pearlly Yan, Ralf Bundschuh, Savita Khanna, Gayle M Gordillo, Michael P Murphy, Sashwati Roy, Chandan K Sen. Genome-wide DNA hypermethylation opposes healing in patients with chronic wounds by impairing epithelial-mesenchymal transition. The Journal of clinical investigation. 132(17). 2022

Ting Zhao, Sheng Liu, Xinchun Ding, Erica M Johnson, Nasser H Hanna, Kanhaiya Singh, Chandan K Sen, Jun Wan, Hong Du, Cong Yan. Lysosomal acid lipase, CSF1R and PD-L1 determine functions of CD11c+ myeloid-derived suppressor cells. JCI insight. 2022

Yashika Rustagi, Ahmed S Abouhashem, Priyanka Verma, Sumit S Verma, Edward Hernandez, Sheng Liu, Manishekhar Kumar, Poornachander R Guda, Rajneesh Srivastava, Sujit K Mohanty, Sedat Kacar, Sanskruti Mahajan, Kristen E Wanczyk, Savita Khanna, Michael P Murphy, Gayle M Gordillo, Sashwati Roy, Jun Wan, Chandan K Sen, Kanhaiya Singh. Endothelial Phospholipase Cγ2 Improves Outcomes of Diabetic Ischemic Limb Rescue Following VEGF Therapy. Diabetes. 71(5):1149-1165. 2022