The Center for Medical Genomics at the Indiana University School of Medicine has recently added the 10x Genomics Xenium to their fleet of instruments to support medical researchers.
Xenium is a new instrument, recently launched by 10x Genomics, that enables transcriptomic analysis at a subcellular level while maintaining spatial context, opening major pathways in disease treatment and biomarker identification. The instrument, which is the first of its kind at IU, has been jointly purchased by the Center for Medical Genomics and the Division of Nephrology on behalf of Michael Eadon, MD, an associate professor of medicine at IU School of Medicine.
The Center for Medical Genomics is a state-of-the-art technology center located in Indianapolis that provides medical scientists with affordable access to high-quality, high-throughput genomics services. The center is equipped with a variety of sequencers and advanced genomics technologies, such as 10x-based single-cell systems (three Chromium, and one Chromium X) for single cell/nucleus RNA-seq, ATAC-seq, multiome (RNA and chromatin accessibility for the same cells/nuclei), and a 10x CytAssist for spatial omics.
The Xenium technology comes with pre-validated biologically relevant targets for tissue panels. Current panels include mouse and human brain, human lung, human breast, human skin, human colon, and multi-tissue panels for human and mouse. Additionally, standalone custom panels can be designed with up to 300 genes for specific research questions.
"This platform will allow researchers within Indiana University and beyond to dive into the world of spatial biology, understanding cellular structure and function at an entirely new level," said Yunlong Liu, PhD, MS, director of both the Center for Medical Genomics and the Center for Computational Biology and Bioinformatics at IU School of Medicine. "Our deep omics expertise positions us well to offer this service to our user base. In addition, multiple investigators in the Center for Computational Biology and Bioinformatics have the expertise in developing and implementing novel bioinformatics tools for analyzing the spatial omics dataset. These skills enable us to fully harness the remarkable potential of this technology."
To learn more about the Xenium or other research services, please contact cmg@iupui.edu.
