69889-Tadepalli, Sirimuvva

Sirimuvva Tadepalli, PhD

Assistant Professor of Microbiology & Immunology

Email
sirtade@iu.edu
Address
Walter Hall (R3), C221
980 W Walnut St
Indianapolis, IN 46202
PubMed:

Bio

Dr. Sirimuvva Tadepalli is an Assistant Professor in the Department of Microbiology & Immunology at IUSM. She completed her PhD in Materials Science from Washington University, where she studied the interactions between functional nanomaterials and biomolecules for immune monitoring and diagnostics. She then transitioned to a postdoctoral training in cancer immunology at Stanford University, where she studied the functional role of myeloid cells in driving response to radiotherapy.

Dr. Tadepalli is a recipient of the Young Investigator Award from the American Association of Immunologists, the Merck Postdoctoral Fellowship from the Life Sciences Research Foundation, the Dean's Postdoctoral Fellowship from Stanford Medicine and the Graduate Student Gold Award from the Materials Research Society. She joined the faculty at IUSM in 2025. 

At IUSM, Tadepalli lab studies the functional and phenotypic heterogeneity of myeloid cells, key coordinators of innate and adaptive immune response during radiation therapy. Her lab integrates molecular engineering and cancer immunology to design nano-enabled therapeutics that reprogram myeloid cells and improve cancer treatment outcomes. 

For more information about our research and opportunities, please reach out.

 

Key Publications

Tadepalli S., Clements D.R., Raquer-McKay, H.R., Lüdtke A., Saravanan S., Seong, D., Vitek, L., Richards, C., Carette, J.E., Graves E.E., Idoyaga J. CD301b+ monocyte-derived DCs mediates resistance to radiotherapy. J. Exp. Med. 2025, 222 (6): e20231717.

Tadepalli, S., Clements, D. R., Saravanan, S., Hornero, R. A., Lüdtke, A., Blackmore, B., Paulo, J. A., Gottfried-Blackmore, A., Seong, D., Park, S., Chan, L., Kopecky, B. J., Liu, Z., Ginhoux, F., Lavine, K. J., Murphy, J. P., Mack, M., Graves, E. E., Idoyaga, J. Rapid Recruitment and IFN-I–Mediated Activation of Monocytes Dictate Focal Radiotherapy Efficacy. Sci. Immunol. 2023, 8 (84).

Tadepalli S., Yim J., Cao S., Wang, Z., Naik, R., Singamaneni S. Metal Organic Framework Encapsulation for the Preservation and Photothermal Enhancement of Enzyme Activity, Small, 2018, 14, 1702382.

Tadepalli S., Slocik J., Gupta M., Naik R., Singamaneni, S. Bio-optics and Bioinspired Optical Materials. Chem. Rev. 2017, 117 (20), 12705–12763.

Tadepalli, S., Wang, Z., Slocik, J., Naik, R., Singamaneni, S. Effect of Size and Curvature on the Enzyme Activity of Bionanoconjugates. Nanoscale, 2017 Oct 19;9 (40), 15666-15672.

Tadepalli S., Yim J., Madireddi K., Luan J., Naik R., Singamaneni S. Gold nanorod-mediated photothermal enhancement of the biocatalytic activity of a polymer-encapsulated enzyme. Chem. Mater. 2017, 29 (15), 6308-6314.

Tadepalli S., Wang Z., Liu K.-K., Jiang Q., Slocik J. M., Naik R. R.; Singamaneni, S. Influence of Surface Charge of the Nanostructures on the Biocatalytic Activity. Langmuir 2017, 33 (26), 6611–6619.

Tadepalli S., Hamper H., Park S. H., Cao S., Naik R. R., Singamaneni S. Adsorption Behavior of Silk Fibroin on Amphiphilic Graphene Oxide. ACS Biomater. Sci. Eng. 2016, 2, 1084-1092.

Tadepalli S., Kuang Z., Jiang Q., Liu K.-K., Fisher M. A., Morrissey J. J., Kharasch E. D., Slocik J. M., Naik R. R., Singamaneni S. Peptide Functionalized Gold Nanorods for the Sensitive Detection of a Cardiac Biomarker Using Plasmonic Paper Devices. Sci. Rep. 2015, 5, 16206.

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