69889-Tadepalli, Sirimuvva

Sirimuvva Tadepalli, PhD

Assistant Professor of Microbiology & Immunology

Email
sirtade@iu.edu
Address
Walter Hall (R3), C221
980 W Walnut St
Indianapolis, IN 46202
PubMed:

Bio

Dr. Sirimuvva Tadepalli is an Assistant Professor in the Department of Microbiology & Immunology at IUSM. She completed her PhD in Materials Science from Washington University, where she studied the interactions between functional nanomaterials and biomolecules for immune monitoring and diagnostics. She then transitioned to a postdoctoral training in cancer immunology at Stanford University, where she studied the functional role of myeloid cells in driving response to radiotherapy. She is a recipient of Young Investigator Award from the American Association of Immunologists, Merck Postdoctoral Fellowship from the Life Sciences Research Foundation, Dean's Postdoctoral Fellowship from Stanford Medicine and Graduate Student Gold Award from the Materials Research Society. She joined the faculty at IUSM in 2025. 

 

At IUSM, Tadepalli lab studies the functional and phenotypic heterogeneity of myeloid cells, key coordinators of innate and adaptive immune response during cancer therapy. We integrate molecular engineering with cancer immunology to design precision nanotherapeutics that enhance treatment responsiveness. Our interdisciplinary research program in nano-enabled myeloid therapeutics spans across cancer immunology, nanotechnology, materials science and molecular engineering, driving innovation at the interface of engineering and biology.  

Reach out to know more about our research and oppurtunities. 

 

Key Publications

Tadepalli S., Clements D.R., Raquer-McKay, H.R., Lüdtke A., Saravanan S., Seong, D., Vitek, L., Richards, C., Carette, J.E., Graves E.E., Idoyaga J. CD301b+ monocyte-derived DCs mediates resistance to radiotherapy. J. Exp. Med. 2025, 222 (6): e20231717.

Tadepalli, S., Clements, D. R., Saravanan, S., Hornero, R. A., Lüdtke, A., Blackmore, B., Paulo, J. A., Gottfried-Blackmore, A., Seong, D., Park, S., Chan, L., Kopecky, B. J., Liu, Z., Ginhoux, F., Lavine, K. J., Murphy, J. P., Mack, M., Graves, E. E., Idoyaga, J. Rapid Recruitment and IFN-I–Mediated Activation of Monocytes Dictate Focal Radiotherapy Efficacy. Sci. Immunol. 2023, 8 (84). 

Tadepalli, S., Wang, Z., Slocik, J., Naik, R., Singamaneni, S. Effect of Size and Curvature on the Enzyme Activity of Bionanoconjugates. Nanoscale, 2017 Oct 19;9 (40), 15666-15672. 

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