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Zhana Duren, PhD

Associate Professor of Medical & Molecular Genetics

Address
HS 4000
MMGE
IN
Indianapolis, IN

Bio

Zhana Duren, Ph.D, is an Associate Professor of Medical and Molecular Genetics at the Indiana University School of Medicine. Dr. Duren’s research focuses on development of computational methods and bioinformatics tools for integration of multi-omics and gene regulatory networks. The long-term research goal is to answer the key scientific question” How non-coding genetic variant act through context specific gene regulatory network to influence phenotype”.

 

Duren Lab Website (https://durenlab.com/)

Key Publications

Qiuyue Yuan and Zhana Duren. Inferring gene regulatory networks from single cell multiome data using atlas-scale external data. Nature Biotechnology (2024): 1-11.  

Xiangqi Bai, Zhana Duren, Lin Wan, and Li C Xia. Joint inference of clonal structure using single-cell genome and transcriptome sequencing data. NAR Genomics and Bioinformatics 6.1 (2024): lqae017.

Zhanying Feng, Zhana Duren, Jingxue Xin, Qiuyue Yuan, Yaoxi He, Bing Su, Wing Hung Wong, and Yong Wang. Heritability enrichment in context-specific regulatory networks improves phenotype-relevant tissue identification. Elife 11 (2022): e82535.

Zhanying Feng, Xianwen Ren, Zhana Duren, and Yong Wang. Human genetic variants associated with COVID-19 severity are enriched in immune and epithelium regulatory networks. Phenomics (2022), 1-15.

Qiuyue Yuan and Zhana Duren. Integration of single-cell multi-omics data by regression analysis on unpaired observations. Genome Biology (2022). 

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