6622-Wen, Qiuting

Qiuting Wen, PhD

Assistant Professor of Radiology & Imaging Sciences

Address
GH4100
RADY
IN
Indianapolis, IN
PubMed:

Bio

Dr. Qiuting Wen (pronounced chiu-ting) received her Ph.D. from the UCSF–UC Berkeley Joint Program in Bioengineering, where she developed a strong interest in translational MRI methods. She later joined Indiana University to focus on advanced diffusion MRI techniques. She developed dynamic diffusion-weighted imaging (dynDWI) to characterize human brain pulsations and cerebrospinal fluid (CSF) dynamics, contributing to the study of brain physiology and the glymphatic waste clearance system.

Her research seeks to apply multimodal imaging approaches to better understand the physiological drivers of CSF circulation and how their dysfunction may relate to aging, Alzheimer’s disease, and CSF disorders.

Lab website: https://sites.google.com/view/wenlab/home



Key Publications

  1. Zhu H, Liu P, Foster E, Jin N, Zhou X, Balédent O, Wen Q*. Quantitative evaluation of low-frequency oscillations using real-time phase-contrast MRI during drowsiness. Fluids Barriers CNS. 2025 Dec 8;22(1):125. doi: 10.1186/s12987-025-00741-x. PMID: 41361451; PMCID: PMC12701604.
  2. Nair V.V., Wright A.M., Xu T, Foster E, Zhou X, Tong Y, Wen Q*. Effect of brief rest on hemodynamics and CSF oscillations across age. Neuroimage. 2025 Nov 1;321:121531. doi: 10.1016/j.neuroimage.2025.121531. Epub 2025 Oct 15. PMID: 41106647.
  3. Wright A.M., Xu T, Koo J, Zhao Y, Tong Y, Wen Q*. An fMRI approach to assess intracranial arterial-to-venous cardiac pulse delay in aging. Imaging Neurosci (Camb). 2025 Oct 30;3:IMAG.a.969. doi: 10.1162/IMAG.a.969. PMID: 41178936; PMCID: PMC12576844.
  4. Wright A.M., Xu T, Tong Y, Wen Q*. HyPER: Region-specific hypersampling of fMRI to resolve low-frequency, respiratory, and cardiac pulsations, revealing age-related differences. Neuroimage. 2025 Nov 1;321:121502. doi: 10.1016/j.neuroimage.2025.121502. Epub 2025 Oct 1. PMID: 41043798.
  5. Wen Q*, Muskat J, Babbs CF, et al. Dynamic diffusion-weighted imaging of intracranial cardiac impulse propagation along arteries to arterioles in the aging brain. Journal of Cerebral Blood Flow & Metabolism. 2025;0(0). doi:10.1177/0271678X251320902
  6. Wright A.M., Xu, T, Ingram J, Koo, J, Zhao Y, Tong Y, Wen Q*. Robust data-driven segmentation of pulsatile cerebral vessels using functional magnetic resonance imaging. Interface Focus. 2024 Dec 6;14(6):20240024. doi: 10.1098/rsfs.2024.0024. PMID: 39649451; PMCID: PMC11620823.
  7. Wright, A.M., Wu, YC., Yang, HC. Tong Y*., Wen Q*. Coupled pulsatile vascular and paravascular fluid dynamics in the human brain. Fluids Barriers CNS 21, 71 (2024). https://doi.org/10.1186/s12987-024-00572-2
  8. Wright AM, Wu YC, Feng L, Wen Q*. Diffusion magnetic resonance imaging of cerebrospinal fluid dynamics: Current techniques and future advancements. NMR Biomed. 2024 May 7:e5162. doi: 10.1002/nbm.5162. Epub ahead of print. PMID: 38715420.
  9. Wright AM, Wu YC, Chen NK, Wen Q*. Exploring Radial Asymmetry in MR Diffusion Tensor Imaging and Its Impact on the Interpretation of Glymphatic Mechanisms. J Magn Reson Imaging. 2023 Dec 29. doi: 10.1002/jmri.29203. Epub ahead of print. PMID: 38156600.
  10. Wen Q*, Wright A, Tong Y, Zhao Y, Risacher SL, Saykin AJ, Wu YC, Limaye K, Riley K. Paravascular fluid dynamics reveal arterial stiffness assessed using dynamic diffusion-weighted imaging. NMR Biomed. 2023 Oct 5:e5048. doi: 10.1002/nbm.5048. Epub ahead of print. PMID: 37798964.
  11. Wen Q, Wang H, Haacke EM, Jiang Q, Hu J. Contribution of Direct Cerebral Vascular Transport in Brain Substance Clearance. Aging Dis. 2023 Aug 13. doi: 10.14336/AD.2023.0426. Epub ahead of print. PMID: 37611901.
  12. Wen Q*, Tong Y, Zhou X, Dzemidzic M, Ho CY, Wu YC. Assessing Pulsatile Waveforms of Paravascular Cerebrospinal Fluid Dynamics within the Glymphatic Pathways using Dynamic Diffusion-weighted Imaging (dDWI). Neuroimage, 2022.
  13. Shahid SS, Wen Q, Risacher SL, Farlow MR, Unverzagt FW, Apostolova LG, Foroud TM, Zetterberg H, Blennow K, Saykin AJ, Wu YC. Hippocampal-subfield microstructures and their relation to plasma biomarkers in Alzheimer's disease. Brain.  2022 Jun 30;145(6):2149-2160. 
  14. Hall Z, Chien B, Risacher SL, Saykin AJ, Wu YC, Wen Q*. Tau deposition and structural connectivity demonstrate differential association patterns with neurocognitive tests. Brain Imaging and Behavior 2021 Sep 17 (Cover article)
  15. Wen Q*, Risacher SL, Xie L, Li J, Harezlak J, Tallman E, Farlow MR, Unverzagt FW, Gao S, Apostolova LG, Saykin AJ, and Wu YC. Tau-related white-matter alterations along spatially selective pathways. Neuroimage. 2021 Feb 1;226:117560.
  16. Wen Q*, Feng L, Zhou K, Wu Y-C. Rapid golden-angle diffusion-weighted propeller MRI for simultaneous assessment of ADC and IVIM. Neuroimage. 2020 Dec;223:117327
  17. Wen Q, Mustafi SM, Harezlak J, Li J, Risacher SL, West JD, Tallman E, Farlow MR, Unverzagt FW, Apostolova LG, Saykin AJ, and Wu YC. White-matter alterations in early-stage Alzheimer’s disease: A tract-specific study. Alzheimers Dement (Amst). 2019 Dec; 11: 576–587
  18. Wen Q, Kodiweera C, Dale BM, Shivraman G, Wu Y-C. Rotating single-shot acquisition (RoSA) with composite reconstruction for fast high-resolution diffusion imaging. Magnetic Resonance in Medicine 2018 Jan,79(1):264-275
  19. Wen Q, Kelley D, Banerjee S, Xu D, Lupo JM, Hess C, Nelson SJ. Clinically feasible NODDI characterization of brain tumor using an optimized multiband EPI at 7T. Neuroimage Clin. 2015, 9: 291–299.
  20. Wen Q, Jalilian L, Lupo JM, Molinaro AM., Chang SM, Clarke J, Prados M, Nelson SJ. Comparison of ADC metrics and their association with outcome for patients with newly diagnosed glioblastoma being treated with radiation therapy, temozolomide, erlotinib and bevacizumab, J Neurooncol. 2015 Jan,121(2):331-9.
  21. Wen Q, Jalilian L, Lupo JM, Li Y, Roy R, Molinaro AM, Chang SM, Prados M, Butowski N, Clarke J, Nelson SJ. Association between diffusion and clinical outcome varies with treatment regimen for patients with newly diagnosed glioblastoma. Transl Oncol. 2015 Dec,8(6):446-55.

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