Tzu-Chieh Ho
Assistant Research Professor of Pediatrics
- Phone
- (317) 274-0043
- Address
-
R4 - W169
PNEB
IN
Indianapolis, IN - PubMed:
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Bio
Dr. Ho’s research focuses on how stem cell-intrinsic and microenvironmental mechanisms drive disease progression and therapeutic resistance in hematologic malignancies, including acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS).
Her work seeks to elucidate the biological basis of disease persistence and treatment failure, with the goal of informing more effective therapeutic strategies for patients with blood cancers.
Dr. Ho’s research aims to develop novel treatments for blood cancers by investigating the mechanistic aspects of hematologic malignancies. Specifically, Dr. Ho focuses on elucidating the role of cancer stem and progenitor populations and their interactions with the bone marrow microenvironment (BMME) in myeloid malignancies, including AML and MDS, using both human specimens and murine models. Her work integrates cell-intrinsic and microenvironmental signaling pathways, with an emphasis on inflammatory and immune regulatory mechanisms, including contributions from mesenchymal stromal cells (MSCs) and immune cell populations, to understand how leukemia stem cells (LSCs) and MDS hematopoietic stem and progenitor cells (HSPCs) sustain survival, resist therapy, and evade immune control.
Desc: Clinical/Translational and Emerging Therapies Award
Scope: University
Date: 2025-07-21
Desc: Early Career Investigator Pilot Award
Scope: University
Date: 2024-07-16