65403-Khomtchouk, Bohdan

Bohdan Khomtchouk

Faculty/Instructor

Assistant Professor of Bioinformatics &amp

Data Science

Phone
(317) 278-5203
Address
IT 477
BHI
IN
Indianapolis, IN

Bio

Dr. Khomtchouk’s research group is pioneering the field of cardioinformatics, working at the nexus of bioinformatics and precision cardiology and attempting to integrate computational biology and AI/machine learning-based approaches to illuminate novel cardio-(vascular/renal/metabolic) biology and enable new therapeutics.

The lab’s principal research focus is on engineering database technologies that provide powerful query and browsing interfaces between biomedical data and user with a primary goal of enabling computationally-derived therapeutics in heart disease and its associated renal and metabolic co-morbidities (e.g., chronic kidney disease and type 2 diabetes). These collectively comprise the leading cause of death worldwide and disproportionally affect older demographics and historically underrepresented minority populations.

Dr. Khomtchouk’s research program is nationally recognized by the American Heart Association (AHA). He also serves on the editorial board of “Circulation: Genomic and Precision Medicine,” the AHA’s flagship computational journal. You may also see Dr. Khomtchouk in the classroom teaching the following courses: INFO B536 Computational Methods for Biomedical Informatics and INFO B556 Biological Database Management.

Key Publications

Szatrowski, A, Maggio, Z, Khomtchouk, B. HDL Cholesterol Is Remarkably Cardioprotective Against Coronary Artery Disease in Native Hawaiians and Pacific Islanders. JACC Adv. 2025 Jun, 4 (6_Part_1) . https://doi.org/10.1016/j.jacadv.2025.101741

Khomtchouk, Bohdan B., et al. "CETP and SGLT2 inhibitor combination therapy increases glycemic control: a 2x2 factorial Mendelian randomization analysis." Frontiers in Endocrinology 15 (2024): 1359780.

Khomtchouk, Bohdan B. "Cardioinformatics Advancements in Healthcare and Biotechnology." Circulation: Genomic and Precision Medicine 16.3 (2023): 283-285.

Hallee, Logan, and Bohdan B. Khomtchouk. "Machine learning classifiers predict key genomic and evolutionary traits across the kingdoms of life." Scientific Reports 13.1 (2023): 2088.

Khomtchouk, Bohdan B. "Cardioinformatics Advancements in Healthcare and Biotechnology." Circulation: Genomic and Precision Medicine 16.3 (2023): 283-285.

Khomtchouk, Bohdan B., et al. "CETP and SGLT2 inhibitor combination therapy improves glycemic control." medRxiv (2023).

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