6485-Cornetta, Kenneth

Kenneth G. Cornetta, MD

Professor of Clinical Medical & Molecular Genetics

Adjunct Clinical Professor of Microbiology & Immunology

Adjunct Clinical Professor of Medicine

Address
Walther Hall
980 W Walnut Street, R3 C649
IB 130
Indianapolis, IN 46202-5121
PubMed:

Bio

As a NRSA fellow at the NIH, Dr. Kenneth Cornetta participated in the first clinical application of gene transfer in humans. Joining the faculty at Indiana University in 1991, he founded the IU Vector Production Facility which has produced over 100 retroviral and lentiviral vector products that have been used in Phase I/II clinical trials throughout the US and abroad. He is currently the director of the NHLBI National Gene Vector Biorepository (www.NGVBCC.org). He has published over 150 publications in the area of gene therapy and bone marrow transplantation. He is a past President of the American Society of Gene and Cell Therapy and the inaugural chair of the Society’s Global Outreach Committee. His current clinical work includes AMPATH Kenya were he serves as director of Palliative Care and is an adjunct lecturer at the Moi University School of Medicine.

Key Publications

155.    Tarus, A.*, Cornetta, K.*, Morogo D, Nyongesa J, Elias H, Boit JM, Palliative Care Needs in Breast Cancer Patients Entering Inpatient Hospice in Western Kenya. Journal of Pain and Symptom Management 63:71-77, 2022. *Contributed equally DOI: 10.1016/j.jpainsymman.2021.07.013  

156.     Reinhardt, B.,  Habib, O., Shaw, K.L., Garabedian, E., Carbonaro-Sarracino, D.A., Terrazas, D., Campo-Fernandez, B., Satiro De Oliveira, S., Moore, T.B., Ikeda, A.K., Engel, B.C., Podsakoff, G.M., Hollis, R.P., Fernandes, A., Jackson, C., Shipien, S., Mishra, S., Davila, A., Mottahedeh, J., Vitromirov, A., Meng, W., Rosenfeld, A.M., Roche, A.M., Hokama, P., Reddy, S., Everett, J., Wang, X., Luning Prak, E.T., Cornetta, K., Hershfield, M.S., Sokolic, R.,De Ravin, S.S., Malech, H.L., Bushman, F.D., Candotti, F., and Kohn, D.B. Long-term outcomes after gene therapy for adenosine deaminase severe combined immune deficiency. Blood 138: 1304-1316, 2021.  PMC8525336

157.     Ghatak, S., Khona, D.K., Sen, A., Huang, K., Jagdale, G., Singh, K., Gopalakrishnan, V., Cornetta, K.G., Roy, S., Khanna, S.. Baker, L.A., Sen, C. K. Electroceutical fabric lowers zeta potential and eradicates coronavirus infectivity upon contact, Scientific Reports 11:21723, 2021. DOI: 10.1038/s41598-021-00910-6. PMC8571396

158.     Cornetta, K., Bonamino, M.,  Mahlangu, J.,  Mingozzi, F.,  Rangarajan, S., Rao, J. Gene Therapy Access: Global Challenges, Opportunities And Views From Brazil, South Africa, And India. Molecular Therapy, 2022. https://doi.org/10.1016/j.ymthe.2022.04.002  PMC9171243

159.     Elias, H.,  Dow, L.A., Boit, J., Asirwa, C.F., Cornetta, K.  Developing Palliative Medicine As An Accredited Medical Specialty In Kenya. JCO Global Oncology. 2022, https://ascopubs.org/doi/full/10.1200/GO.22.00025 PMC9173565

160.     Cornetta, K., Lin, T-Y., Pellin, D., Kohn, D.B. Meeting FDA Guidance Recommendations for Replication Competent Virus and Insertional Oncogenesis Testing. Molecular Therapy -Methods and Clinical Development. (2023) 28: 28-29. PMC9791246

 161.     Cornetta, K., Yao J., House, K., Duffy, L., Adusumilli, P.S., Beyer, R., Booth, C., Brenner, M., Curran, K., Grilley, B., Heslop, H., Hinrichs, C.S., Kaplan, R.N., Kiem, H-P., Kochenderfer, J., Kohn, D.B., Mailankody, S., Norberg, S.M., O'Cearbhaill, R.E., Pappas, J., Park, J., Ramos, C., Ribas, A., Rivière, I., Rosenberg, S.A., Sauter, C., Shah, N., Slovin, S.F., Thrasher, A., Williams, D.A., and Lin, T-Y.  Replication Competent Retrovirus Testing (RCR) in the National Gene Vector Biorepository: No Evidence of RCR In 1595 Post-Treatment Peripheral Blood Samples Obtained From 60 Clinical Trials. Molecular Therapy, (2023) 31: 801-809.  PMC10014217

162.     Cornetta, K., Nyariki, S., Manji, I., Kiplimo, I., Korir, M., Muinga, E., Busakhala, N., Elias, H. Telehospice for Cancer Patients Discharged from A Tertiary Care Hospital In Western Kenya.  Journal of Pain and Symptom Management, (2023) 65:378-387. PMC10106447             

163.     Cornetta,K., Kay, S., Urio, F., Minja, I.K., Mbugi, E., Mgaya, J., Mselle, T., Nkya, S. Mohamed Alimohamed, M.Z., Ndaki, K., Bonamino, M. Koya,R.C., Shah, L.D.,Mahlangu, J., Drago, D., Rangarajan,S., and Jayandharan, J.R.  Implementation of a Gene Therapy Education Initiative by the ASGCT and Muhimbili University of Health and Allied Sciences, Molecular Therapy, Molecular Therapy, (2023)  https://doi.org/10.1016/j.ymthe.2023.07.019  

164.     Elias, H., Kisembe, K., Nyariki, S., Kiplimo, I., Amisi, J. Boit, J., Tarus, A., Mohamed, N., Cornetta, K.  Impact of training on knowledge, confidence and attitude amongst Community Health Volunteers in the provision of community-based palliative care in rural Kenya. BMC Palliative Care, (2024) 23:97. https://doi.org/10.1186/s12904-024-01415-5 

165.     Doxzen, K.W., Adair, J.E.,  Fonseca Bazzo, Y.M., Bukini, D., Dalal, V., Cornetta, K., Renato Luiz Guerino-Cunha, R.L., Hongeng, S., Jotwani, G., Batista Silva Júnior, J., Kityo-Mutuluuza, C., Lakshmanan, K., Mahlangu, J., Makani, J., Mathews, V., Ozelo, M.C., Rangarajan, S., Scholefield, J., McCune, J.M. The translational gap for gene therapies in low- and middle-income countries. Science Translational Medicine 2024, 16, eadn1902. 

166.     Cornetta, K., Lin, T-Y., Tao, H., Huang, J., Piskorowski, J., Wilcox, P., Xie, D., Yao, J., House, K., Nance, E., Duffy., L.  Product Enhanced Reverse Transcriptase for assessing replication competent virus in vectors retroviral vectors pseudotyped with GALV and VSV-G envelopes. J. of Virological Methods, https://doi.org/10.1016/j.jviromet.2024.114988  PMC pending

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