Salvatore Condello, PhD

Bio

Dr. Condello earned his doctorate in Biochemistry, Cell and Molecular Biology at the University of Messina and completed a postdoctoral fellowship in 2015 at Indiana University School of Medicine in the laboratory of Dr. Matei, Department of Obstetrics and Gynecology. In 2016, he joined Northwestern University Feinberg School of Medicine, Department of Obstetrics and Gynecology as an Assistant Research Professor. Dr. Condello is currently Assistant Professor in the Department of Obstetrics and Gynecology at Indiana University School of Medicine in the subspecialty of Gynecology Oncology. His ongoing research is focused in identifying and validating important oncogenic pathways and metabolic pattern alterations correlated with ovarian cancer stem cells survival and proliferation, with the final aim to find new functional target genes and test novel therapeutics. Recently, Dr. Condello has been recognized and awarded by the Department of Defense with the Ovarian Cancer Academy – Early-Career Investigator Award for his studies on Investigating and Targeting Ovarian Cancer Stem Cells Interactions with the Tumor Niche.

Key Publications

1. Condello S, Sima LE, Ivan C, Cardenas H, Schiltz GE, Mishra RK, Matei D. Tissue transglutaminase regulates interactions between ovarian cancer stem cells and the tumor niche. Cancer Res. 2018 Jun 1;78(11):2990-3001.

2. Junjie Li, Salvatore Condello, Jessica Thomes-Pepin, Xiaoxiao Ma, Yu Xia, Thomas D. Hurley, Daniela Matei, Ji-Xin Cheng. Lipid Desaturation Is a Metabolic Marker and Therapeutic Target of Ovarian Cancer Stem Cells. Cell Stem Cell. 2016 Dec 8. pii: S1934-5909(16)30400-3.

3. Lee J, Condello S, Yakubov B, Emerson R, Caperell-Grant A, Hitomi K, Xie J, Matei D. Tissue Transglutaminase Mediated Tumor-Stroma Interaction Promotes Pancreatic Cancer Progression. Clin Cancer Res. 2015 Oct 1; 21(19):4482-93.

4. Condello S, Morgan CA, Nagdas S, Cao L, Turek J, Hurley TD, Matei D. β-Catenin-regulated ALDH1A1 is a target in ovarian cancer spheroids. Oncogene. 2015 Apr 30;34(18):2297-308.

5. Yinu Wang, Horacio Cardenas, Fang Fang, Salvatore Condello, Pietro Taverna, Matthew Segar, Yunlong Liu, Kenneth P. Nephew, and Daniela Matei. Epigenetic Targeting of Ovarian Cancer Stem Cells. Cancer Res. 2014 Sep 1; 74(17):4922-36.

6. Condello S, Cao L, Matei D. Tissue transglutaminase regulates β-catenin signaling through a c-Src-dependent mechanism. FASEB J. 2013 Aug; 27(8):3100-12. doi: 10.1096/fj.12-222620. PMC4050431.