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Kevin Booth, PhD

Assistant Professor of Medical & Molecular Genetics

Bio

Kevin T.A. Booth, PhD, is an Assistant Professor in the Department of Medical and Molecular Genetics. He is a Clinical Laboratory Director at the Indiana University Genetic Testing Laboratories and Co-director of the Azaiez-Booth Laboratory.

Dr. Booth received his bachelor’s degree in chemistry from the University of Iowa and his PhD in genetics from the University of Iowa. He completed a postdoctoral fellowship focused on gene therapy at Harvard Medical School, followed by a Laboratory Genetics and Genomics fellowship at Indiana University School of Medicine.

Dr. Booth’s research focuses on hereditary conditions, with an emphasis on hereditary hearing loss. His work includes projects aimed at understanding the genetic basis of hearing loss and developing molecular therapeutic approaches to address these conditions.

Key Publications

Booth KTA, Jangam SV, Chui MMC, Treat K, Graziani L, Soldano A, Ruan Y, Wan-Hei Hui J, White K, Christensen CK, Lynnes T, Yamamoto S, Kanca O, Tsang MHY, Lynch SA, Mullegama SV, Batista J, Iancu D, Joss SK, Wong SYY, Mak CCY, Kwong AKY, Bellen HJ, Conboy E, Sanges R, Leung AY, Wangler MF, Chung BHY, Vetrini F. De novo and inherited variants in DDX39B cause a novel neurodevelopmental syndrome. Brain. 2025 Feb 7:awaf035. doi: 10.1093/brain/awaf035. Epub ahead of print. PMID: 39918047.

Booth KTA, Schulte RR, Smith L, Gao H, Stohler RA, Liu Y, Reshmi SC, Vance GH. ZMIZ1::ABL1 Fusion: An Uncommon Molecular Event With Clinical Implications in Pediatric Cancer. Arch Pathol Lab Med. 2025 Feb 1;149(2):159-164. doi: 10.5858/arpa.2024-0082-OA. PMID: 38749501.

Fayette MA, Booth KTA, Lynnes TC, Luna C, Minich DJ, Wilson TE, Miller MJ. Biochemical and molecular confirmation of alkaptonuria in a Sumatran orangutan (Pongo abelii). Mol Genet Metab. 2023 Jul;139(3):107628. doi: 10.1016/j.ymgme.2023.107628. Epub 2023 Jun 15. PMID: 37354891.

Hirsch Y, Chung WK, Novoselov S, Weimer LH, Rossor A, LeDuc CA, McPartland AJ, Cabrera E, Ekstein J, Scher S, Nelson RF, Schiavo G, Henderson LB, Booth KTA. Biallelic Loss-of-Function Variants in BICD1 Are Associated with Peripheral Neuropathy and Hearing Loss. Int J Mol Sci. 2023 May 17;24(10):8897. doi: 10.3390/ijms24108897. PMID: 37240244; PMCID: PMC10219021.

Booth KT, Hirsch Y, Vardaro AC, Ekstein J, Yefet D, Quint A, Weiden T, Corey DP. Identification of Novel and Recurrent Variants in MYO15A in Ashkenazi Jewish Patients With Autosomal Recessive Nonsyndromic Hearing Loss. Front Genet. 2021 Oct 18;12:737782. doi: 10.3389/fgene.2021.737782. PMID: 34733312; PMCID: PMC8558392. 

Full pub list: https://www.ncbi.nlm.nih.gov/myncbi/kevin.booth.1/bibliography/public/

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