5098-Kono, Tatsuyoshi

Tatsuyoshi Kono, PhD

Associate Research Professor of Pediatrics

Phone
(317) 278-9517
Address
1210 Waterway Blvd.,
Ste. 4100,
MS 2021
Indianapolis, IN 46202
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Bio

Dr. Tatsuyoshi Kono is an Associate Professor in the Pediatrics Department at the Indiana University School of Medicine (IUSM). He earned his Ph.D. at Tohoku University in Japan and completed his postdoctoral training in basic diabetes research at IUSM. Since joining the Diabetes Research Center in 2008, Dr. Kono’s research has centered on understanding pathways that alter β cell function and survival under diabetic conditions.

To date, Dr. Kono has focused on defining the role of β cell endoplasmic reticulum (ER) calcium dyshomeostasis and key calcium regulatory proteins during the progression of diabetes. His research will identify important signaling pathways that synergistically regulate ER, mitochondrial, and Golgi calcium homeostasis and will define new mechanisms that regulate β cell function and health. One of Dr. Kono’s goals is to continue to provide an open environment for education and R&D as a leader in international collaboration in diabetes research.

Full publication list

Key Publications

 

  1. Lee CC, Kono T, Syed F, Weaver SA, Sohn P, Wu W, Chang G, Liu J, Slak Rupnik M, Evans-Molina C. (2024). Sodium Butyrate Prevents Cytokine-Induced β-Cell Dysfunction Through Restoration of Stromal Interaction Molecule 1 Expression and Activation of Store-Operated Calcium Entry. FASEB J. 38(15):e23853. [doi: 10.1096/fj.202302501RR] PMID: 39120544
  2. Williams KE, Zou Y, Qiu B, Kono T, Guo C, Garcia D, Chen H, Graves T, Lai Z, Evans-Molina C, Ma YY, Liangpunsakul S, Yong W, Liang T. (2023). Sex-Specific Impact of Fkbp5 on Hippocampal Response to Acute Alcohol Injection: Involvement in Alterations of Metabolism-Related Pathways. Cells 13(1):89. [doi: 10.3390/cells13010089]

  3. Lee CC, Kono T, Syed F, Weaver SA, Sohn P, Wu W, Chang G, Liu J, Rupnik MS, Evans-Molina C. (2023). Histone Deacetylase Inhibitors Prevent Cytokine-Induced β Cell Dysfunction Through Restoration of Stromal Interaction Molecule 1 Expression and Activation of Store-Operated Calcium Entry. bioRxiv. [doi: 10.1101/2023.12.06.570443] 
  1. *†Iida H, Kono T, Lee CC, Krishnan P, Arvin MC, Weaver SA, Jarvela TS, Branco RCS, McLaughlin MR, Bone RN, Tong X, Arvan P, Lindberg I, Evans-Molina C. (2023). SERCA2 regulates proinsulin processing and processing enzyme maturation in pancreatic beta cells. Diabetologia 66(11):2042-2061. [doi: 10.1007/s00125-023-05979-4] First co-author of the paper. Had a role as a mentor of the first authors.
  1. *†Sohn P, McLaughlin MR, Krishnan P, Wu W, Slak Rupnik M, Takasu A, Senda T, Lee CC, Kono T, Evans-Molina C. (2023). Stromal Interaction Molecule 1 Maintains β-Cell Identity and Function in Female Mice Through Preservation of G-Protein-Coupled Estrogen Receptor 1 Signaling. Diabetes 72(10):1433-1445. [doi: 10.2337/db22-0988]  Corresponding author of the paper. Had a role as a mentor of the first authors.
  2. Davidson RK, Kanojia S, Wu W, Kono T, Xu J, Osmulski M, Bone RN, Casey N, Evans-Molina C, Sims EK, Spaeth JM. (2023). The Chd4 Helicase Regulates Chromatin Accessibility and Gene Expression Critical for β-Cell Function In Vivo. Diabetes 72(6):746-757. [doi: 10.2337/db22-0939]

7.       Yan S, Conley JM, Reilly AM, Stull ND, Abhyankar SD, Ericsson AC, Kono T, Molosh AI, Kubal CA, Evans-Molina C, and Ren H. (2022). Intestinal Gpr17 deficiency improves glucose metabolism by promoting GLP-1 secretion. Cell Reports 38, 110179. 10.1016/j.celrep.2021.110179.

 

8. *†Tong X, Chaudhry Z, Lee CC, Bone RN, Kanojia S, Maddatu J, Sohn P, Weaver SA, Robertson MA, Petrache I, Evans-Molina C, Kono T.
Cigarette smoke exposure impairs β-cell function through activation of oxidative stress and ceramide accumulation. Mol Metab. 2020 Mar 13;37:100975. doi:10.1016/j.molmet.2020.100975. Link

 

9. *Kono T , Tong X, Taleb S, Bone RN, Iida H, Lee CC, Sohn P, Gilon P, Roe MW, Evans-Molina C.
Impaired Store-Operated Calcium Entry and STIM1 Loss Lead to Reduced Insulin Secretion and Increased Endoplasmic Reticulum Stress in the Diabetic β cell.   Diabetes. 2018 Nov;67(11):2293-2304  https://pubmed.ncbi.nlm.nih.gov/30131394/

 

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