Md Mamun Al-Amin, PhD
Assistant Research Professor of Medical & Molecular Genetics
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NB 103
MMGE
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Indianapolis, IN - PubMed:
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Bio
Md Mamun Al-Amin, PhD, is an Assistant Research Professor in the Department of Medical and Molecular Genetics at the Stark Neurosciences Research Institute. His research focuses on understanding how brain cells and connections are affected in neurodegenerative diseases, particularly Alzheimer’s disease.
Dr. Amin combines advanced brain imaging techniques with tissue analysis to study how changes in brain structure relate to cognitive decline. He utilizes tools such as diffusion-weighted magnetic resonance imaging, a specialized MRI method to maps the brain’s communication pathways, alongside immunohistochemistry and behavioral testing apparatus. Through these methods, he investigates how damage to white matter and neural networks influences resilience or vulnerability to dementia.
His work aims to better understand how Alzheimer’s-related changes, including amyloid buildup, interact with the brain’s wiring system. By linking imaging findings with cellular-level evidence, he seeks to contribute to earlier detection strategies and the development of more effective treatments.
Dr. Amin earned his PhD in Neuroscience from the Queensland Brain Institute. In addition to his research, he is committed to mentoring students and trainees and fostering collaboration across scientific disciplines. He also participates in community outreach and educational initiatives to promote public understanding of brain health.
Key Publications
Al-Amin, M. M., Kim, B., Karahan, H., Tate, M. D., Walsh, S. P., Puntambekar, S. S., ... & Kim, J. (2025). Apolipoprotein ε4 exacerbates white matter impairment in a mouse model of Aβ amyloidosis by decreasing actively myelinating oligodendrocytes. Alzheimer's & dementia: the journal of the Alzheimer's Association, 21(10), e70791.
Karahan, H., Hartigan, K., Al-Amin, M. M., John, S. K., McCord, B., Wijeratne, H. S., ... & Kim, J. (2025). Deletion of neuronal Idol ameliorates Alzheimer's disease-related pathologies via APOE receptors. Alzheimer's & dementia: the journal of the Alzheimer's Association, 21(12), e70949.
Kim, B., Dabin, L. C., Tate, M. D., Karahan, H., Sharify, A. D., Acri, D. J., Al-Amin, M. M., Philtjens, S., Smith, D. C., Wijeratne, H. R. S., Park, J. H., Jucker, M., & Kim, J. (2024). Effects of SPI1-mediated transcriptome remodeling on Alzheimer's disease-related phenotypes in mouse models of Aβ amyloidosis. Nat Commun, 15(1), 3996.
Cadiz, M. P., Gibson, K. A., Todd, K. T., Nascari, D. G., Massa, N., Lilley, M. T., Olney, K. C., Al-Amin, M. M., Jiang, H., Holtzman, D. M., & Fryer, J. D. (2024). Aducanumab anti-amyloid immunotherapy induces sustained microglial and immune alterations. J Exp Med, 221(2).
Karahan, H., Smith, D. C., Kim, B., McCord, B., Mantor, J., John, S. K., Al-Amin, M. M., Dabin, L. C., & Kim, J. (2023). The effect of Abi3 locus deletion on the progression of Alzheimer's disease-related pathologies. Front Immunol, 14, 1102530.
Al-Amin, M. M., Sullivan, R. K., Alexander, S., Carter, D. A., Bradford, D., & Burne, T. H. (2022). Impaired spatial memory in adult vitamin D deficient BALB/c mice is associated with reductions in spine density, nitric oxide, and neural nitric oxide synthase in the hippocampus. AIMS neuroscience, 9(1), 31.
Smith, D. C., Karahan, H., Wijeratne, H. R. S., Al-Amin, M., McCord, B., Moon, Y., & Kim, J. (2022). Deletion of the Alzheimer's disease risk gene Abi3 locus results in obesity and systemic metabolic disruption in mice. Frontiers in aging neuroscience, 14, 1035572.
Karahan, H., Smith, D. C., Kim, B., Dabin, L. C., Al-Amin, M. M., Wijeratne, H. R. S., Pennington, T., Viana di Prisco, G., McCord, B., Lin, P. B., Li, Y., Peng, J., Oblak, A. L., Chu, S., Atwood, B. K., & Kim, J. (2021). Deletion of Abi3 gene locus exacerbates neuropathological features of Alzheimer's disease in a mouse model of Aβ amyloidosis. Sci Adv, 7(45), eabe3954.
| Year | Degree | Institution |
|---|---|---|
| 2019 | PhD | The University of Queensland |
| 2012 | M.Sc. | Ludwig Maximilian University of Munich |
| 2010 | MS | Jahangirnager University |
| 2006 | BPHARM | Jahangirnager University |
Dr. Amin’s research investigates the structural and functional alterations within critical brain regions, specifically the white matter and the hippocampus. He focuses on the role of white matter, which comprises approximately half of the human brain and facilitates long-range connectivity across neural networks. Although disruptions in white matter integrity frequently emerge during the early stages of Alzheimer’s disease, the precise cellular mechanisms governing these changes remain largely undefined.
His work aims to elucidate the cellular underpinnings of impaired white matter integrity and its subsequent contribution to cognitive decline. Additionally, Dr. Amin examines the hippocampus, a region essential for spatial navigation, learning, and memory. The hippocampus exhibits consistent structural vulnerability across a broad spectrum of neuropsychiatric and neurodegenerative disorders.
Through these investigations, he seeks to advance the understanding of neurobiological mechanisms underlying cognitive impairment. Ultimately, his research aims to identify novel therapeutic targets for Alzheimer's disease and related neurological conditions.
Desc: T32 Training Grant on Alzheimer’s Disease and ADRD
Scope: National
Date: 2022-09-01