
Md Mamun Al-Amin, PhD
Postdoctoral Fellow in Medical & Molecular Genetics
Bio
I am a Postdoctoral fellow at the Stark Neurosciences Research Institute, Indiana University School of Medicine. My research focuses on understanding the cellular and molecular mechanisms underlying neurodegenerative diseases, particularly Alzheimer’s disease. I integrate advanced neuroimaging techniques—including NODDI- an advanced diffusion tensor imaging, structural MRI, Magnetic resonance spectroscopy —with behavioral and histological analyses to investigate how white matter integrity, myelination, and neuronal connectivity contribute to cognitive resilience and decline. His current work explores the regulatory role of microRNA in oligodendrocyte function and axonal health in amyloidosis models. Originally from Bangladesh, I am deeply committed to advancing diversity and inclusion in neuroscience while fostering innovative, translational research that bridges molecular pathology and brain network organization.
Key Publications
1) Al-Amin MM, Kim B, Karahan H, Tate MD, Walsh SP, Puntambekar SS, et al. Apolipoprotein ε4 exacerbates white matter impairment in a mouse model of Aβ amyloidosis by decreasing actively myelinating oligodendrocytes. Alzheimers Dement. 2025;21:e70791.
2) Kim, B., Dabin, L. C., Tate, M. D., Karahan, H., Sharify, A. D., Acri, D. J., Al-Amin, M. M., Philtjens, S., Smith, D. C., Wijeratne, H. R. S., Park, J. H., Jucker, M., & Kim, J. (2024). Effects of SPI1-mediated transcriptome remodeling on Alzheimer's disease-related phenotypes in mouse models of Aβ amyloidosis. Nat Commun, 15(1), 3996. https://doi.org/10.1038/s41467-024-48484-x
3) Quddus, A.H.M.R., Pervin M.S., Zinchenko A., Al-Amin, M. M., (2024). Investigating the role of structural connectivity in the individuals with moderate hearing loss. Brain disorders. 16, 100165. https://doi.org/10.1016/j.dscb.2024.100165
4) Cadiz, M. P., Gibson, K. A., Todd, K. T., Nascari, D. G., Massa, N., Lilley, M. T., Olney, K. C., Al-Amin, M. M., Jiang, H., Holtzman, D. M., & Fryer, J. D. (2024). Aducanumab anti-amyloid immunotherapy induces sustained microglial and immune alterations. J Exp Med, 221(2). https://doi.org/10.1084/jem.20231363
5) Li, W., Al-Amin, M. M., & Nair, A. (2023). Editorial: New insights into the disorder of brain connectivity in schizophrenia. Front Neuroimaging, 2, 1266695. https://doi.org/10.3389/fnimg.2023.1266695
6) Karahan, H., Smith, D. C., Kim, B., McCord, B., Mantor, J., John, S. K., Al-Amin, M. M., Dabin, L. C., & Kim, J. (2023). The effect of Abi3 locus deletion on the progression of Alzheimer's disease-related pathologies. Front Immunol, 14, 1102530. https://doi.org/10.3389/fimmu.2023.1102530
7) Smith, D. C., Karahan, H., Wijeratne, H. R. S., Al-Amin, M., McCord, B., Moon, Y., & Kim, J. (2022). Deletion of the Alzheimer's disease risk gene Abi3 locus results in obesity and systemic metabolic disruption in mice. Frontiers in aging neuroscience, 14, 1035572. https://doi.org/10.3389/fnagi.2022.1035572
8) Karahan, H., Smith, D. C., Kim, B., Dabin, L. C., Al-Amin, M. M., Wijeratne, H. R. S., Pennington, T., Viana di Prisco, G., McCord, B., Lin, P. B., Li, Y., Peng, J., Oblak, A. L., Chu, S., Atwood, B. K., & Kim, J. (2021). Deletion of Abi3 gene locus exacerbates neuropathological features of Alzheimer's disease in a mouse model of Aβ amyloidosis. Sci Adv, 7(45), eabe3954. https://doi.org/10.1126/sciadv.abe3954
PhD study in Australia
1) Al-Amin, M. M., Sullivan, R. K. P., Alexander, S., Carter, D. A., Bradford, D., & Burne, T. H. J. (2022). Impaired spatial memory in adult vitamin D deficient BALB/c mice is associated with reductions in spine density, nitric oxide, and neural nitric oxide synthase in the hippocampus. AIMS Neurosci, 9(1), 31-56. https://doi.org/10.3934/Neuroscience.2022004
2) Al-Amin, M.M., Bradford, D., Sullivan, R. K. P., Kurniawan, N. D., Moon, Y., Han, S. H., Zalesky, A., & Burne, T. H. J. (2019). Vitamin D deficiency is associated with reduced hippocampal volume and disrupted structural connectivity in patients with mild cognitive impairment. Hum Brain Mapp, 40(2), 394-406. https://doi.org/10.1002/hbm.24380
3) Al-Amin, M. M., Sullivan, R. K. P., Kurniawan, N. D., & Burne, T. H. J. (2019). Adult vitamin D deficiency disrupts hippocampal-dependent learning and structural brain connectivity in BALB/c mice. Brain Struct Funct, 224(3), 1315-1329. https://doi.org/10.1007/s00429-019-01840-w
4) Jaeschke, K. N., Blackmore, D. G., Groves, N. J., Al-Amin, M. M., Alexander, S., & Burne, T. H. J. (2019). Vitamin D Levels Are Not Associated with Hippocampal-Dependent Learning in Young Adult Male C57BL/6J Mice: A Negative Report. Journal of Psychiatry and Brain Science, 4(2), e190008, Article e190008. https://doi.org/10.20900/jpbs.20190008
5) Al-Amin, M.M., Sullivan, R., Jaeschke, K., & Burne, T. (2017). Impact of combined adult vitamin D deficiency and second-hit exposures on brain function. CABI Reviews, 1–16. https://doi.org/10.1079/pavsnnr201712040
6) Zinchenko, A., Al-Amin, M. M., Alam, M. M., Mahmud, W., Kabir, N., Reza, H. M., & Burne
T. H. J. (2017). Content specificity of attentional bias to threat in post-traumatic stress disorder. J Anxiety Disord, 50, 33-39. https://doi.org/10.1016/j.janxdis.2017.05.006
7) Zinchenko, A., Mahmud, W., Alam, M. M., Kabir, N., & Al-Amin, M. M. (2016). Picture Novelty Influences Response Selection and Inhibition: The Role of the In-Group Bias and Task-Difficulty. PLoS One, 11(10), e0165470. https://doi.org/10.1371/journal.pone.0165470
Teaching at North South University, Bangladesh
1) Al-Amin, M. M., Mahmud, W., Pervin, M. S., Ridwanul Islam, S. M., Ashikur Rahman, M., & Zinchenko, A. (2019). Astaxanthin ameliorates scopolamine-induced spatial memory deficit via reduced cortical-striato-hippocampal oxidative stress. Brain Res, 1710, 74-81. https://doi.org/10.1016/j.brainres.2018.12.014
2) Al-Amin, M. M., Chowdury, M. I. A., Saifullah, A. R. M., Alam, M. N., Jain, P., Hossain, M., Alam, M. A., Kazi, M., Ahmad, A., Raish, M., Alqahtani, A., & Reza, H. M. (2019). Levocarnitine Improves AlCl(3)-Induced Spatial Working Memory Impairment in Swiss albino Mice. Front Neurosci, 13, 278. https://doi.org/10.3389/fnins.2019.00278
3) Al-Amin, M. M., Choudhury, M. F. R., Chowdhury, A. S., Chowdhury, T. R., Jain, P., Kazi, M., Alkholief, M., Alshehri, S. M., & Reza, H. M. (2018). Pretreatment With Risperidone Ameliorates Systemic LPS-Induced Oxidative Stress in the Cortex and Hippocampus. Front Neurosci, 12, 384. https://doi.org/10.3389/fnins.2018.00384
4) Rizwan, A., Zinchenko, A., Özdem, C., Rana, M. S., & Al-Amin, M. M. (2017). The effect of black tea on human cognitive performance in a cognitive test battery. Clinical Phytoscience, 3(1), 13. https://doi.org/10.1186/s40816-017-0049-4
5) Al-Amin, M.M., Alam, T., Hasan, S. M., Hasan, A. T., & Quddus, A. H. (2016). Prenatal maternal lipopolysaccharide administration leads to age- and region-specific oxidative stress in the early developmental stage in offspring. Neuroscience, 318, 84-93. https://doi.org/10.1016/j.neuroscience.2016.01.002
6) Al-Amin, M. M., Sultana, R., Sultana, S., Rahman, M. M., & Reza, H. M. (2016). Astaxanthin ameliorates prenatal LPS-exposed behavioral deficits and oxidative stress in adult offspring. BMC Neurosci, 17, 11. https://doi.org/10.1186/s12868-016-0245-z
7) Al-Amin, M. M., Reza, H. M., Saadi, H. M., Mahmud, W., Ibrahim, A. A., Alam, M. M., Kabir, N., Saifullah, A. R., Tropa, S. T., & Quddus, A. H. (2016). Astaxanthin ameliorates aluminum chloride-induced spatial memory impairment and neuronal oxidative stress in mice. Eur J Pharmacol, 777, 60-69. https://doi.org/10.1016/j.ejphar.2016.02.062
8) Zannat, R., Nasir, U. M. M., Atiar, R. M., Jannatul, A., & and Al Amin, M. M. (2016). Antihistamines considerably modulate the cognitive and psychomotor performance of human volunteers. Cogent Psychology, 3(1), 1216242. https://doi.org/10.1080/23311908.2016.1216242
9) Al-Amin, M.M., Akhter, S., Hasan, A. T., Alam, T., Nageeb Hasan, S. M., Saifullah, A. R., & Shohel, M. (2015). The antioxidant effect of astaxanthin is higher in young mice than aged: a region-specific study on brain. Metab Brain Dis, 30(5), 1237-1246. https://doi.org/10.1007/s11011-015-9699-4
10) Das, B. K., Al-Amin, M. M., Chowdhury, N. N., Majumder, M. F., Uddin, M. N., & Pavel, M. A. (2015). Analgesic, anti-inflammatory, and anti-oxidant activities of Phlogacanthus thyrsiflorus leaves. J Basic Clin Physiol Pharmacol, 26(2), 153-159. https://doi.org/10.1515/jbcpp-2013-0164
11) Al-Amin, M. M., Rahman, M. M., Khan, F. R., Zaman, F., & Mahmud Reza, H. (2015). Astaxanthin improves behavioral disorder and oxidative stress in prenatal valproic acid-induced mice model of autism. Behav Brain Res, 286, 112-121. https://doi.org/10.1016/j.bbr.2015.02.041
12) Al-Amin, M. M., Hasan, S. M., Alam, T., Hasan, A. T., Hossain, I., Didar, R. R., Alam, M. A., & Rahman, M. M. (2014). Tadalafil enhances working memory, and reduces hippocampal oxidative stress in both young and aged mice. Eur J Pharmacol, 745, 84-90. https://doi.org/10.1016/j.ejphar.2014.10.026
13) Das, B. K., Al-Amin, M. M., Russel, S. M., Kabir, S., Bhattacherjee, R., & Hannan, J. M. (2014). Phytochemical Screening and Evaluation of Analgesic Activity of Oroxylum indicum. Indian J Pharm Sci, 76(6), 571-575.
14) Shohel, M., Rahman, M. M., Zaman, A., Uddin, M. M., Al-Amin, M. M., & Reza, H. M. (2014). A systematic review of effectiveness and safety of different regimens of levonorgestrel oral tablets for emergency contraception. BMC Womens Health, 14, 54. https://doi.org/10.1186/1472-6874-14-54
15) Wykowska, A., Chellali, R., Al-Amin, M. M., & Müller, H. J. (2014). Implications of robot actions for human perception. How do we represent actions of the observed robots? International Journal of Social Robotics, 6, 357-366.
16) Ali Adnan, M. S., Al-Amin, M. M., Nasir Uddin, M. M., Shohel, M., Bhattacharjee, R., Hannan, J. M., & Das, B. K. (2014). Analgesic, anti-inflammatory, and antipyretic effects of Ixora coccinea. J Basic Clin Physiol Pharmacol. https://doi.org/10.1515/jbcpp-2013-0125
17) Al-Amin, M. M., & Reza, H. M. (2014). Neuroinflammation: Contemporary anti-inflammatory treatment approaches. Neurosciences (Riyadh), 19(2), 87-92.
18) Al-Amin, M. M., Uddin, M. M., Rahman, M. M., Reza, H. M., & Rana, M. S. (2013). Effect of diclofenac and antidepressants on the inflammatory response in astrocyte cell culture. Inflammopharmacology, 21(6), 421-425. https://doi.org/10.1007/s10787-013-0181-9
19) Al-Amin, M. M., Nasir Uddin, M. M., & Mahmud Reza, H. (2013). Effects of antipsychotics on the inflammatory response system of patients with schizophrenia in peripheral blood mononuclear cell cultures. Clin Psychopharmacol Neurosci, 11(3), 144-151. https://doi.org/10.9758/cpn.2013.11.3.144
Master’s Study in Germany
1) Wykowska, A., Chellali, R., Al-Amin, M. M., & Müller, H. J. (2012). Does observing artificial robotic systems influence human perceptual processing in the same way as observing humans? Social Robotics: 4th International Conference, ICSR 2012, Chengdu, China, October 29-31, 2012. Proceedings 4,
2) Al-Amin, M. M., Rana, A. Z. M. S., Uddin, M. M. N., & Pervin, M. S. (2012). Study on polypharmacy in patients with cardiovascular diseases. Journal of Applied Pharmaceutical Science, 2(12), 053-060.
Year | Degree | Institution |
---|---|---|
2019 | PhD | The University of Queensland |
2012 | M.Sc. | Ludwig Maximilian University of Munich |
2010 | MS | Jahangirnager University |
2006 | BPHARM | Jahangirnager University |
I have a longstanding interest in brain structures such as white matter and the hippocampus—both of which undergo significant alterations in many neurological diseases. White matter, which constitutes about half of the human brain, maintains structural connectivity between distant regions and serves as the foundation for functional communication across neural networks. Although disruptions in white matter integrity emerge early in Alzheimer’s disease, the cellular mechanisms underlying these changes remain poorly understood. My research aims to elucidate the cellular basis of impaired white matter integrity and its relationship to cognitive deficits in Alzheimer’s disease. Additionally, I am interested in the hippocampus—a midbrain structure critical for spatial navigation, learning, and memory—which shows consistent structural vulnerability across numerous brain disorders.
Desc: T32 Training Grant on Alzheimer’s Disease and ADRD
Scope: National
Date: 2022-09-01