Hyun Cheol Roh, PhD
Assistant Professor of Biochemistry & Molecular Biology
- hyunroh@iu.edu
- Phone
- (317) 274-9622
- Address
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Indiana University School of Medicine
635 Barnhill Dr. Medical Sciences Building Room MS1017A(lab)/MS1021G(office)
Indianapolis, IN 46202-5126 - PubMed:
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Bio
Dr. Roh received his B.S in Genetic Engineering and M.S. in Biochemistry from Korea University. He completed his Ph.D. in Molecular Cell Biology at Washington University in St. Louis with Dr. Kerry Kornfeld, working on homeostatic mechanisms for zinc metabolism using C. elegans. Dr. Roh received his postdoctoral training at Harvard Medical School & Beth Israel Deaconess Medical Center under Dr. Evan Rosen, working on the molecular mechanisms that regulate adipocyte identity in response to physiological stimulations and pathological conditions. He was promoted to Instructor in Medicine at Harvard Medical School in 2018. Dr. Roh joined the faculty of the Department of Biochemistry and Molecular Biology in the fall of 2019.
Key Publications
So J, Strobel O, Wann J, Kim K, Paul A, Acri DJ, Dabin LC, Kim J, Peng G, Roh HC. Robust single-nucleus RNA sequencing reveals depot-specific cell population dynamics in adipose tissue remodeling during obesity. eLife. 2025 Jan 13;13:RP97981. doi: 10.7554/eLife.97981. PMID: 39804687; PMCID: PMC11729396.
Kim K, Wann J, Kim HG, So J, Rosen ED, Roh HC. Uncoupling protein 1-driven Cre (Ucp1-Cre) is expressed in the epithelial cells of mammary glands and various non-adipose tissues. Molecular Metabolism. 2024 Jun;84:101948. doi: 10.1016/j.molmet.2024.101948. Epub 2024 Apr 25. PMID: 38677508; PMCID: PMC11070624.
Kim K, Taleb S, So J, Wann J, Cheol Roh H. Adipocyte-Specific ATAC-Seq with Adipose Tissues Using Fluorescence-Activated Nucleus Sorting. J Vis Exp. 2023 Mar 17;(193). doi: 10.3791/65033. PMID: 37010301.
So J, Taleb S, Wann J, Strobel O, Kim K, Roh HC. Chronic cAMP activation induces adipocyte browning through discordant biphasic remodeling of transcriptome and chromatin accessibility. Molecular Metabolism. 2022 Dec;66:101619. doi: 10.1016/j.molmet.2022.101619. Epub 2022 Oct 21. PMID: 36273781; PMCID: PMC9636484.
| Year | Degree | Institution |
|---|---|---|
| 2011 | PhD | Washington University |
| 2005 | MS | Korea University |
| 2003 | BS | Korea University |
The Roh Lab studies how epigenetic mechanisms, including chromatin organization and nuclear architecture, regulate cellular functions in response to metabolic signals, with the goal of developing treatments for metabolic diseases and improving human health.
Adipocyte Identity Control and Reprogramming
Adipocytes play a key role in nutrient and energy homeostasis and come in different flavors: white, brown, beige and more. We are looking for ways to control and reprogram adipocyte identity to improve our metabolic health and prevent diseases such as obesity and diabetes.
Cellular Plasticity in Physiology and Human Disease
Once differentiated, somatic cell types maintain cellular identity and fulfill their unique cellular functions, while some cell types have potentials to switch identity. We are exploring how such cellular plasticity contributes to normal physiology in mammals and is implicated in human disease.
Development of Cutting-Edge Epigenomic Techniques
We have established powerful techniques for cell type-specific epigenomic analysis and single cell/nuclei gene expression profiling in vivo. We keep developing new methods that enable us to gain new insights into metabolism research and more.