Luke C. Dabin, PhD

Bio

Luke C. Dabin studied Biochemistry at The University of Birmingham, UK, between 2008-2012. Graduating with a 1st Class Hons MSc, they then applied for and were awarded a Daiwa Anglo-Japanese Foundation scholarship to study Japanese in Tokyo. After one year of intensive study they passed the Japanese Language Proficiency Test N3 level and began an internship at RIKEN's Brain Science Institute, mentored by Jiro Takano in the Takaomi Saido laboratory.

There their interest in amyloid protein broadened to proteopathic neurodgenerative diseases, and they began graduate studies at University College London, supported by The Leonard Wolfson Training Programme in Neurodegeneration. They studied DNA methylation in sporadic Prion Disease patient blood under the mentorship of Simon Mead and Emmanuelle Viré, and in 2019 they graduated with a PhD in Neuroscience. They immediately began a postdoctoral position in the Jungsu Kim laboratory, where their current focus is on omics and computational biology, particularly single-cell studies of Alzheimer's Disease mouse models.

Key Publications

Loss of Inpp5d has disease-relevant and sex-specific effects on glial transcriptomes. Luke C. Dabin*, Holly Kersey*, Byungwook Kim, Dominic J. Acri, Daniel Sharify, Audrey Lee-Gosselin, Cristian A. Lasagna-Reeves, Adrian L. Oblak, Bruce T. Lamb, Jungsu Kim, Alz Dem 2024, 20 (8) 5311-5323 

Effects of SPI1-mediated transcriptome remodeling on Alzheimer’s disease-related phenotypes in mouse models of Aβ amyloidosis. Byungwook Kim, Luke Child Dabin*, Mason Douglas Tate*, Hande Karahan, Ahmad Daniel Sharify, Dominic J. Acri, Md Mamun Al-Amin, Stéphanie Philtjens, Daniel Curtis Smith, H. R. Sagara Wijeratne, Jung Hyun Park, Mathias Jucker, Jungsu Kim, Nat Comms 2024, 15 (1)

Deletion of Abi3 gene locus exacerbates neuropathological features of Alzheimer’s disease in a mouse model of Aβ amyloidosis. Hande Karahan, Daniel C. Smith, Byungwook Kim, Luke C. Dabin, Md Mamun Al-Amin, H.R. Sahara Wijeratne, Taylor Pennington, Gonzalo Viana Di Prisco, Brianne McCord, Peter Bor-Chian Lin, Yuxin Li, Junmin Peng, Adrian L. Oblak, Shaoyou Chu, Brady K. Atwood, Jungsu Kim, Sci Adv 2021, 7 (45)

Altered DNA methylation profiles in blood from patients with sporadic Creutzfeldt-Jakob disease. Luke C. Dabin*, Fernando Guntoro*, Tracy Campbell, Tony Bélicard, Adam R. Smith, Rebecca G. Smith, Rachel Raybould, Jonathan M. Schott, Katie Lunnon, Peter Sarkies, John Collinge, Simon Mead, Emmanuelle Viré, Acta Neuropathol 2020, 140, 863-879

* Denotes both authors contributed equally