42774-Karahan, Hande

Hande Karahan, PhD

Assistant Research Professor of Medical & Molecular Genetics

Phone
(317) 278-6353
Address
NB 108
MMGE
IN
Indianapolis, IN

Bio

Dr. Karahan received her Pharmacy degree from Hacettepe University, Turkey in 2010 and completed her PhD in Pharmacology at the same university in 2016.

During her PhD, she investigated the role of neurosterodiogenic enzymes in Alzheimer's disease pathogenesis. She joined Dr. Jungsu Kim's laboratory as a postdoctoral fellow at the Mayo Clinic in Jacksonville, Florida in 2017.

In 2018, she joined the Stark Neurosciences Research Institute at the Indiana University School of Medicine with Dr. Kim's laboratory. Dr. Karahan is currently an Assistant Research Professor at the Department of Medical and Molecular Genetics, Indiana University School of Medicine.

Her current research focuses on understanding the role of microglial actin-regulatory genes, such as ABI3, and lipid-regulating proteins in the pathogenesis of Alzheimer's disease. 

Key Publications

Kim B, Dabin LC, Tate MD, Karahan H, Sharify AD, Acri DJ, Al-Amin MM, Philtjens S, Smith DC, Wijeratne HRS, Park JH, Jucker M, Kim J. Effects of SPI1-mediated transcriptome remodeling on Alzheimer's disease-related phenotypes in mouse models of Aβ amyloidosis. Nat Commun. 2024 May 11;15(1):3996. doi: 10.1038/s41467-024-48484-x. PMID: 38734693; PMCID: PMC11088624.

Tate MD, Karahan H, Kim J. APOE loss of function: A genetic shield against Alzheimer's disease. Neuron. 2024 Apr 3;112(7):1033-1035. doi: 10.1016/j.neuron.2024.03.003. PMID: 38574724.

Acri DJ, You Y, Tate MD, Karahan H, Martinez P, McCord B, Sharify AD, John S, Kim B, Dabin LC, Philtjens S, Wijeratne HRS, McCray TJ, Smith DC, Bissel SJ, Lamb BT, Lasagna-Reeves CA, Kim J. Network analysis identifies strain-dependent response to tau and tau seeding-associated genes. J Exp Med. 2023 Nov 6;220(11):e20230180. doi: 10.1084/jem.20230180. Epub 2023 Aug 22.

Karahan H, Smith DC, Kim B, McCord B, Mantor J, John SK, Al-Amin MM, Dabin LC, Kim J. The effect of Abi3 locus deletion on the progression of Alzheimer’s disease-related pathologies. Front. Immunol.,14:1102530 (2023).

Smith DC, Karahan H, Wijeratne HRS, Al-Amin MM, McCord B, Moon Y, Kim J. Deletion of the Alzheimer’s disease risk gene Abi3 locus results in obesity and systemic metabolic disruption in mice. Front. Aging Neurosci., 14:1035572 (2022).

Karahan H, Smith DC, Kim B, Dabin LC, Al-Amin MM, Wijeratne HRS, Pennington T, di Prisco GV, McCord B, Lin PB, Li Y, Peng J, Oblak AL, Chu S, Atwood BK, Kim J. Deletion of Abi3 locus exacerbates neuropathological features of Alzheimer’s disease in a mouse model of Aβ amyloidosis. Sci. Adv. 7, eabe3954 (2021).

Ao Z, Cai H, Wu Z, Song S, Karahan H, Kim B, Lu HC, Kim J, Mackie K, Guo F. Tubular human brain organoids to model microglia-mediated neuroinflammation. Lab Chip. 2021 Jul 13;21(14):2751-2762. 

Karahan H, Dabin LC, Tate MD, Kim J. MicroRNAs on the move: microRNAs in astrocyte-derived ApoE particles regulate neuronal function. Neuron. 2021 Mar 17;109(6):907-909. doi: 10.1016/j.neuron.2021.02.021. PMID: 33735610.

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