41977-Kim, Jungsu

Jungsu Kim, PhD

P. Michael Conneally Professor of Medical and Molecular Genetics

Phone
(317) 278-6351
Address
NB 108B
MMGE
Indianapolis, IN
PubMed:

Bio

Dr. Kim is the P. Michael Conneally Professor of Medical and Molecular Genetics. Dr. Kim graduated Summa Cum Laude in 2000 from Pohang University of Science & Technology in Korea with a bachelor’s degree in life science. He earned his Ph.D. from Mayo Clinic College of Medicine in 2007 under the guidance of Dr. Todd Golde and completed his postdoctoral training at Washington University in the laboratory of Dr. David Holtzman. After 3 years of postdoctoral training, he established his laboratory at Washington University, as an Assistant Professor in the Department of Neurology. In June 2013, Dr. Kim joined the Department of Neuroscience at Mayo Clinic. After 5 years of tenure as a Senior Associate Consultant I at Mayo Clinic, Dr. Kim relocated his laboratory to the Stark Neurosciences Research Institute at IU School of Medicine in 2018.

Key Publications

1.         Dabin, L.C., et al. Loss of Inpp5d has disease-relevant and sex-specific effects on glial transcriptomes. Alzheimers Dement 20, 5311-5323 (2024).
https://alz-journals.onlinelibrary.wiley.com/doi/full/10.1002/alz.13901

2.         Kim, B., et al. Effects of SPI1-mediated transcriptome remodeling on Alzheimer’s disease-related phenotypes in mouse models of Aβ amyloidosis. Nat. Commun. 15, 3996 (2024).
https://www.nature.com/articles/s41467-024-48484-x

3.         Tate, M., et al. Deletion of miR-33, a regulator of the ABCA1–APOE pathway, ameliorates neuropathological phenotypes in APP/PS1 mice. Alzheimer's & dementia n/a(2024).
https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.14243

4.         Tate, M.D., et al. APOE loss of function: A genetic shield against Alzheimer’s disease. Neuron 112, 1033-1035 (2024).

           https://www.cell.com/neuron/abstract/S0896-6273(24)00157-0

5.         Acri, D.J., et al. Network analysis identifies strain-dependent response to tau and tau seeding-associated genes. J. Exp. Med. 220(2023).
https://rupress.org/jem/article/220/11/e20230180/276197/Network-analysis-identifies-strain-dependent

6.         Karahan, H., et al. Deletion of Abi3 gene locus exacerbates neuropathological features of Alzheimer's disease in a mouse model of Abeta amyloidosis. Science advances 7, eabe3954 (2021).
https://www.science.org/doi/10.1126/sciadv.abe3954

7.         Karahan, H., et al. MicroRNAs on the move: microRNAs in astrocyte-derived ApoE particles regulate neuronal function. Neuron 109, 907-909 (2021).
https://www.cell.com/neuron/fulltext/S0896-6273(21)00121-5

8.         Liao, F., et al. Apolipoprotein E metabolism and functions in brain and its role in Alzheimer's disease. Curr. Opin. Lipidol. 28, 60-67 (2017).

9.         Yoon, H., et al. MicroRNAs in brain cholesterol metabolism and their implications for Alzheimer's disease. Biochim. Biophys. Acta 1861, 2139-2147 (2016).

10.       Kim, J., et al. miR-27a and miR-27b regulate autophagic clearance of damaged mitochondria by targeting PTEN-induced putative kinase 1 (PINK1). Mol. Neurodegener. 11, 55 (2016).

11.       Kim, J., et al. microRNA-33 Regulates ApoE Lipidation and Amyloid-beta Metabolism in the Brain. J. Neurosci. 35, 14717-14726 (2015).

12.       Choi, J., et al. The E3 ubiquitin ligase Idol controls brain LDL receptor expression, ApoE clearance, and Abeta amyloidosis. Sci. Transl. Med. 7, 314ra184 (2015).

13.       Kim, J., et al. Normal cognition in transgenic BRI2-Abeta mice. Mol. Neurodegener. 8, 15 (2013).

14.       Kim, J., et al. miR-106b impairs cholesterol efflux and increases Aβ levels by repressing ABCA1 expression. Exp. Neurol. 235, 476-483 (2012).

15.       Kim, J., et al. Anti-apoE immunotherapy inhibits amyloid accumulation in a transgenic mouse model of Abeta amyloidosis. J. Exp. Med. 209, 2149-2156 (2012).

16.       Basak, J.M., et al. Measurement of apolipoprotein E and amyloid beta clearance rates in the mouse brain using bolus stable isotope labeling. Mol. Neurodegener. 7, 14 (2012).

17.       Kim, J., et al. Haploinsufficiency of human APOE reduces amyloid deposition in a mouse model of amyloid-beta amyloidosis. J. Neurosci. 31, 18007-18012 (2011).

18.       Castellano, J.M., et al. Human apoE Isoforms Differentially Regulate Brain Amyloid-β Peptide Clearance. Sci. Transl. Med. 3, 89ra57 (2011).

19.       Kim, J., et al. Prion-like behavior of amyloid-beta. Science 330, 918-919 (2010).

20.       Basak, J.M., et al. Differential effects of ApoE isoforms on dendritic spines in vivo: linking an Alzheimer's disease risk factor with synaptic alterations. J. Neurosci. 30, 4526-4527 (2010).

21.       Kim, J., et al. Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular Abeta clearance. Neuron 64, 632-644 (2009).

22.       Kim, J., et al. The role of apolipoprotein E in Alzheimer's disease. Neuron 63, 287-303 (2009).

23.       Kim, J., et al. BRI2 (ITM2b) Inhibits Abeta Deposition In Vivo. J Neurosci. 28, 6030-6036 (2008).

24.       Kim, J., et al. Abeta40 inhibits amyloid deposition in vivo. J. Neurosci. 27, 627-633 (2007).

25.       McGowan, E., et al. Abeta42 is essential for parenchymal and vascular amyloid deposition in mice. Neuron 47, 191-199 (2005).

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