Robert E. Stratford, PhD
Adjunct Clinical Associate Professor of Medicine
- Phone
- (317) 274-2822
- Address
-
R2 480
CPHR
IN
Indianapolis, IN - PubMed:
-
| Year | Degree | Institution |
|---|---|---|
| 1987 | PhD | University of Southern California |
| 1979 | BS | University of California, Irvine |
The goal of my research is to use pharmacokinetic and pharmacodynamic (PK/PD) modeling approaches to describe the processes of drug absorption, distribution, metabolism and excretion (PK), and ensuing drug actions (PD) based on pre-clinical experimentation to confirm, and ultimately predict drug exposure and ensuing effects in humans. To support this goal, in vitro techniques are employed alongside in vivo non-clinical experiments. This integrated approach informs model design, and is subsequently used to 1) translate drug exposure and effects from animals to humans, and 2) develop hypotheses that broaden and/or deepen our understanding of the pharmacokinetic and pharmacodynamic elements of a patient's response to pharmacotherapy.
Development of a Semimechanistic Pharmacokinetic-Pharmacodynamic Model Describing Dextroamphetamine Exposure and Striatal Dopamine Response in Rats and Nonhuman Primates following a Single Dose of Dextroamphetamine.
van Gaalen MM; Schlumbohm C; Folgering JH; Adhikari S; Bhattacharya C; Steinbach D; Stratford RE Jr; The Journal of pharmacology and experimental therapeutics 2019 Feb 7
van Gaalen MM; Schlumbohm C; Folgering JH; Adhikari S; Bhattacharya C; Steinbach D; Stratford RE Jr; The Journal of pharmacology and experimental therapeutics 2019 Feb 7
Development of a non-human primate model to support CNS translational research: Demonstration with D-amphetamine exposure and dopamine response.
Folgering JH; Choi M; Schlumbohm C; van Gaalen MM; Stratford RE Jr; Journal of neuroscience methods 2019 Feb 12
Folgering JH; Choi M; Schlumbohm C; van Gaalen MM; Stratford RE Jr; Journal of neuroscience methods 2019 Feb 12
Cellular Pharmacokinetic Model-Based Analysis of Genistein, Glyceollin, and MK-571 Effects on 5 (and 6)-Carboxy-2',7'-Dichloroflourescein Disposition in Caco-2 Cells.
Drennen C; Gorse E; Stratford RE Jr; Journal of pharmaceutical sciences 2017 Dec 14
Drennen C; Gorse E; Stratford RE Jr; Journal of pharmaceutical sciences 2017 Dec 14
Glyceollin Effects on MRP2 and BCRP in Caco-2 Cells, and Implications for Metabolic and Transport Interactions.
Chimezie C; Ewing A; Schexnayder C; Bratton M; Glotser E; Skripnikova E; Sá P; Boué S; Stratford RE Jr; Journal of pharmaceutical sciences 2016 Jan 11
Chimezie C; Ewing A; Schexnayder C; Bratton M; Glotser E; Skripnikova E; Sá P; Boué S; Stratford RE Jr; Journal of pharmaceutical sciences 2016 Jan 11
Development of a Rat Plasma and Brain Extracellular Fluid Pharmacokinetic Model for Bupropion and Hydroxybupropion Based on Microdialysis Sampling, and Application to Predict Human Brain Concentrations.
Cremers TI; Flik G; Folgering JH; Rollema H; Stratford RE Jr; Drug metabolism and disposition: the biological fate of chemicals 2016 Feb 25
Cremers TI; Flik G; Folgering JH; Rollema H; Stratford RE Jr; Drug metabolism and disposition: the biological fate of chemicals 2016 Feb 25
Prediction of brain clozapine and norclozapine concentrations in humans from a scaled pharmacokinetic model for rat brain and plasma pharmacokinetics.
Li CH; Stratford RE Jr; Velez de Mendizabal N; Cremers TI; Pollock BG; Mulsant BH; Remington G; Bies RR; Journal of translational medicine 2014 Aug 20
Li CH; Stratford RE Jr; Velez de Mendizabal N; Cremers TI; Pollock BG; Mulsant BH; Remington G; Bies RR; Journal of translational medicine 2014 Aug 20
Ethyl (3S,4aR,6S,8aR)-6-(4-ethoxycar- bonylimidazol-1-ylmethyl)decahydroiso-quinoline-3-carboxylic ester: a prodrug of a GluR5 kainate receptor antagonist active in two animal models of acute migraine.
Filla SA; Winter MA; Johnson KW; Bleakman D; Bell MG; Bleisch TJ; Castaño AM; Clemens-Smith A; del Prado M; Dieckman DK; Dominguez E; Escribano A; Ho KH; Hudziak KJ; Katofiasc MA; Martinez-Perez JA; Mateo A; Mathes BM; Mattiuz EL; Ogden AM; Phebus LA; Stack DR; Stratford RE; Ornstein PL; Journal of medicinal chemistry 2002 Sep 26
Filla SA; Winter MA; Johnson KW; Bleakman D; Bell MG; Bleisch TJ; Castaño AM; Clemens-Smith A; del Prado M; Dieckman DK; Dominguez E; Escribano A; Ho KH; Hudziak KJ; Katofiasc MA; Martinez-Perez JA; Mateo A; Mathes BM; Mattiuz EL; Ogden AM; Phebus LA; Stack DR; Stratford RE; Ornstein PL; Journal of medicinal chemistry 2002 Sep 26
Application of oral bioavailability surrogates in the design of orally active inhibitors of rhinovirus replication.
Stratford RE Jr; Clay MP; Heinz BA; Kuhfeld MT; Osborne SJ; Phillips DL; Sweetana SA; Tebbe MJ; Vasudevan V; Zornes LL; Lindstrom TD; Journal of pharmaceutical sciences 1999 Aug
Stratford RE Jr; Clay MP; Heinz BA; Kuhfeld MT; Osborne SJ; Phillips DL; Sweetana SA; Tebbe MJ; Vasudevan V; Zornes LL; Lindstrom TD; Journal of pharmaceutical sciences 1999 Aug
Activities of the semisynthetic glycopeptide LY191145 against vancomycin-resistant enterococci and other gram-positive bacteria.
Nicas TI; Mullen DL; Flokowitsch JE; Preston DA; Snyder NJ; Stratford RE; Cooper RD; Antimicrobial agents and chemotherapy 1995 Nov
Nicas TI; Mullen DL; Flokowitsch JE; Preston DA; Snyder NJ; Stratford RE; Cooper RD; Antimicrobial agents and chemotherapy 1995 Nov
American Society for Clinical Pharmacology and Therapeutics
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