Matthew D. Durbin, MD
Associate Professor of Pediatrics
- Phone
- (317) 274-4716
- Address
-
1044 W. Walnut Street
R4 221
Indianapolis, IN 46202 - PubMed:
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Bio
Dr. Durbin received a B.S. and B.A. from Indiana University and an M.D. from Wright State University. He completed Pediatric Residency at Loyola University Chicago and Neonatal-Perinatal Medicine Fellowship at Vanderbilt University. He is an Associate Professor of Pediatrics and Assistant Chief of Research for the Division of Neonatal-Perinatal Medicine, and provides clinical care as an attending neonatologist at Riley Hospital for Children, Eskenazi Hospital, and Franciscan Hospital, as well as telemedicine services to Margaret Mary Hospital in Batesville, Indiana. Dr. Durbin is a physician-investigator in the Herman B Wells Center for Pediatric Research and conducts basic/translational research on the genetic and developmental mechanisms of congenital heart disease. His work has been supported by the NIH through an NHLBI K08 career development award, a project within an NHLBI Program Project Grant on ventricular wall morphogenesis, and an NHLBI R01 examining the role of maternal obesity in congenital heart disease. He has published on the diagnostic yield and clinical impact of genetic testing in newborns with congenital heart defects and serves on NIH study sections.
| Year | Degree | Institution |
|---|---|---|
| 2018 | MS | Indiana University |
| 2016 | Fellowship | Vanderbilt University Medical Center |
| 2013 | Residency | Loyola University Medical Center |
| 2010 | MD | Wright State University |
| 2006 | BA&BS | Indiana University |
Congenital heart disease is the most common birth defect and a leading cause of death in the newborn period, yet its etiology remains largely unknown. During Neonatology Fellowship, Dr. Durbin used next-generation sequencing and disease modeling with patient-derived induced pluripotent stem cells to study the genetics and mechanisms of congenital heart disease. After Fellowship he joined the faculty at Indiana University and established an independent laboratory in the Herman B Wells Center for Pediatric Research. His lab uses genomics, gene editing, animal models, and cell culture models to elucidate the developmental pathways and molecular mechanisms altered in structural heart disease, with a focus on SHROOM3 and the WNT/planar cell polarity signaling pathway during cardiac development. A second major area of investigation examines how the maternal environment, including obesity and folic acid status, influences offspring cardiac development and the risk of congenital heart defects. In parallel, Dr. Durbin leads translational work on the optimal genetic evaluation of newborns with congenital heart disease in the ICU, including the diagnostic yield of exome and rapid genome sequencing and the impact of genetic testing guidelines on clinical care.
Pediatrics, Neonatal-Perinatal Medicine, Congenital Heart Disease