Dongbing Lai, PhD
Associate Research Professor of Medical & Molecular Genetics
- Phone
- (317) 278-9544
- Address
-
HS 4059
MMGE
IN
Indianapolis, IN - PubMed:
-
Bio
Dr. Lai’s research focuses on looking for genes and gene networks responsible for common diseases such as osteoporosis, intracranial aneurysms, alcoholism, Parkinson's disease and Alzheimer's disease by using genome wide array data, whole exome and whole genome data.
Dr. Lai’s research area includes study design to maximize power, bioinformatics and database tools for data processing and storage, annotating and predicting the function of genetic variant, and statistical analysis methods.
Key Publications
Barr P, Neale Z, Chatzinakos C, Schulman J, Mullins N, Zhang J, Chorlian D, Kamarajan C, Kinreich S, Pandey A, Pandey G, de Viteri SS, Acion L, Bauer L, Bucholz K, Chan G, Dick D, Edenberg H, Foroud T, Goate A, Hesselbrock V, Johnson E, Kramer J, Lai D, Plawecki M, Salvatore J, Wetherill L, Agrawal A, Porjesz B, Meyers J. Clinical, genomic, and neurophysiological correlates of lifetime suicide attempts among individuals with alcohol dependence. Res Sq. 2024. Epub 20240209. doi: 10.21203/rs.3.rs-3894892/v1. PubMed PMID: 38405959; PMCID: PMC10889049.
Schuckit MA, Smith TL, Danko G, Bucholz KK, Hesselbrock V, Hesselbrock M, Kuperman S, Kramer J, Nurnberger JI, Lai D, Chan G, Kamarajan C, Kuo S, Dick DM, Tear J, Mendoza LA, Edenberg HJ, Porjesz B. Do personality characteristics predict future alcohol problems after considering current demography, substance use, and alcohol response? Alcohol Clin Exp Res. 2023. Epub 20230418. doi: 10.1111/acer.15085. PubMed PMID: 37073476.
Saenz de Viteri S, Zhang J, Johnson EC, Barr PB, Edenberg HJ, Hesselbrock VM, Nurnberger JI, Jr., Pandey AK, Kamarajan C, Kinreich S, Tischfield JA, Plawecki MH, Kramer JR, Lai D, Kuperman S, Chan G, McCutcheon VV, Bucholz KK, Porjesz B, Meyers JL. Genomic risk for post-traumatic stress disorder in families densely affected with alcohol use disorders. Mol Psychiatry. 2023. Epub 20230621. doi: 10.1038/s41380-023-02117-9. PubMed PMID: 37344610.
Li R, Reiter JL, Chen AB, Chen SX, Foroud T, Edenberg HJ, Lai D, Liu Y. RNA alternative splicing impacts the risk for alcohol use disorder. Mol Psychiatry. 2023. Epub 20230523. doi: 10.1038/s41380-023-02111-1. PubMed PMID: 37217680.
Lai D, Zhang M, Li R, Zhang C, Zhang P, Liu Y, Gao S, Foroud T. Identifying Genes Associated with Alzheimer's Disease Using Gene-Based Polygenic Risk Score. J Alzheimers Dis. 2023. Epub 20231118. doi: 10.3233/jad-230510. PubMed PMID: 38007651.
Lai D, Kuo SI, Wetherill L, Aliev F, Zhang M, Marco A, Schwantes-An TH, Dick D, Francis MW, Johnson EC, Kamarajan C, Kinreich S, Kuperman S, Meyers J, Nurnberger JI, Liu Y, Edenberg HJ, Porjesz B, Agrawal A, Foroud T, Schuckit M, Plawecki MH, Bucholz KK, McCutcheon VV. Associations between alcohol use disorder polygenic score and remission in participants from high-risk families and the Indiana Biobank. Alcohol Clin Exp Res (Hoboken). 2023. Epub 20231206. doi: 10.1111/acer.15239. PubMed PMID: 38054532.
Kamarajan C, Pandey AK, Chorlian DB, Meyers JL, Kinreich S, Pandey G, Subbie-Saenz de Viteri S, Zhang J, Kuang W, Barr PB, Aliev F, Anokhin AP, Plawecki MH, Kuperman S, Almasy L, Merikangas A, Brislin SJ, Bauer L, Hesselbrock V, Chan G, Kramer J, Lai D, Hartz S, Bierut LJ, McCutcheon VV, Bucholz KK, Dick DM, Schuckit MA, Edenberg HJ, Porjesz B. Predicting Alcohol-Related Memory Problems in Older Adults: A Machine Learning Study with Multi-Domain Features. Behav Sci (Basel). 2023;13(5). Epub 20230518. doi: 10.3390/bs13050427. PubMed PMID: 37232664; PMCID: PMC10215235.
Johnson EC, Salvatore JE, Lai D, Merikangas AK, Nurnberger JI, Tischfield JA, Xuei X, Kamarajan C, Wetherill L, Collaborators C, Rice JP, Kramer JR, Kuperman S, Foroud T, Slesinger PA, Goate AM, Porjesz B, Dick DM, Edenberg HJ, Agrawal A. The collaborative study on the genetics of alcoholism: Genetics. Genes, Brain and Behavior. 2023;22(5):e12856. doi: https://doi.org/10.1111/gbb.12856.
Cosentino J, Behsaz B, Alipanahi B, McCaw ZR, Hill D, Schwantes-An TH, Lai D, Carroll A, Hobbs BD, Cho MH, McLean CY, Hormozdiari F. Inference of chronic obstructive pulmonary disease with deep learning on raw spirograms identifies new genetic loci and improves risk models. Nat Genet. 2023;55(5):787-95. Epub 20230417. doi: 10.1038/s41588-023-01372-4. PubMed PMID: 37069358.
Colbert SMC, Mullins N, Chan G, Meyers JL, Schulman J, Kuperman S, Lai D, Nurnberger J, Plawecki MH, Kamarajan C, Anokhin AP, Bucholz KK, Hesselbrock V, Edenberg HJ, Kramer J, Dick DM, Porjesz B, Agrawal A, Johnson EC. Polygenic Contributions to Suicidal Thoughts and Behaviors in a Sample Ascertained for Alcohol Use Disorders. Complex Psychiatry. 2023;9(1-4):11-23. Epub 20230118. doi: 10.1159/000529164. PubMed PMID: 38058956; PMCID: PMC10697665.
| Year | Degree | Institution |
|---|---|---|
| 2015 | PhD | Indiana University |
| 2003 | MS | Indiana University-Purdue University Indianapolis |
| 1993 | BS | Nankai University |
Dr. Lai's research includes discovery genes responsible for common diseases such as osteoporosis, intracranial aneurysms, alcoholism, Parkinson's disease and Alzheimer's disease by using genome wide array data, whole exome and whole genome data.
His research area includes study design to maximize power; bioinformatics and database tools to process raw data; annotating and predicting the function of genetic variant and statistical analysis methods.