Tyler Nguyen, PhD

Bio

Tyler Nguyen, Ph.D. M.S., is a trained neuroscientist involved both in preclinical and clinical research studies. Dr. Nguyen received both his Bachelor of Science (Chemistry and Applied Mathematics, 2012) at Purdue University; a Master in Science (Anatomy & Cellular Biology, 2015); a doctoral Ph.D. (Medical Neuroscience, 2020) from Indiana University School of Medicine followed with a post-doctoral fellowship with Dr. Fletcher White at IU School of Medicine. Dr. Nguyen was appointed as a Research Assistant Professor at IU School of Medicine in the Department of Anesthesia and presently on the faculty scientist appointment at Richard L. Roudebush VA Medical Center. 

Dr. Nguyen's works focuses on the understanding neural plasticity, neuroinflammation, and developing new therapeutic strategies for post traumatic brain injury (TBI) associated diseases. Currently, his brain injury works focus on both clinical populations and preclinical animal models aim to understand the underlying acute-to-chronic inflammatory mechanisms, its association with long-term pain, and designing better treatment approach. Dr. Nguyen is highly trained in neuroimaging, electrophysiological recordings, preclinical neurosurgical techniques, and preclinical & clinical pain behavioral testings.

Key Publications

• Nguyen, T.; Nguyen, N.; Cochran, A.; Smith, J.; Al-Juboori, M.; Brumett, A.; Saxena, S.; Talley, S.; Campbell, E.; Obukhov, A.; White, F. "Repeated closed-head mild traumatic brain injury induced inflammation is associated with nociceptive sensitization." Journal of Neuroinflammation (2023), 20 (196).
• Smith, J.; Nguyen, T.; Davis, B.; Juboori, M.; White, F. “Repeated Mild Traumatic Brain Injury in Mice Elicits Long Term Innate Immune Cell Alterations in Blood, Spleen, and Brain.” Frontiers in Neuroscience. 2023.
• Naugle K.; Nguyen, T.; Smith, J.; Saxe J.; White F.A. “Racial differences in head pain and other pain-related outcomes following mild traumatic brain injury.” Journal of Neurotrauma. 2022. DOI: 1089/neu.2022.0415.
• Naugle, K.; Corrona, S.; Smith, J.; Nguyen, T.; Saxe, J.; White, F.A. “Physical activity behavior in the first month after mild traumatic brain injury is associated with physiological psychological risk factors for chronic pain.” Pain Reports (2021), 6(4): e969.
• Wu, W.*; Nguyen, T.*; Ordaz, J.; Zhang, Y.; Liu, N.; Hu, X.; Ping, X.; Wu, X.; Liu, Y.; Qu, W.; Gao, S.; Shields, C.; Jin, X.; Xu, X. “Bilateral activity stimulation of motor cortex promotes forelimb recovery after spinal cord injury.” Journal of Clinical Investigation (2022), 7(12): e158150.
• Zhang E.; Abdel-Mottaleb M.; Nguyen, T.; Jin, X.; Noga, B.; Ganzer, P.; Khizroev, S. “Magnetic-field-synchronized wireless activation of action potentials by magnetoelectric nanoparticles.” SSRN Journal. 2022. DOI: 10.2139/ssrn.4167458
• Nguyen, T.; Gao, J.; Wang, P.; Nagesetti, A.; Andrews, P.; Masood, S.; Vriesman, Z.; Liang, P.; Khizroev, S.; Jin, X. “In vivo wireless brain stimulation via non-invasive and targeted delivery of magnetoelectric nanoparticles.” Neurotherapeutics. 18:2091-2106. (2021).
• Nguyen, T.; Vriesman, Z.; Andrews, P.; Masood S.; Khizroev S.; Jin, X. “Magneto-electric nanoparticles (MENs) cobalt ferrite-barrium titanate (CoFe2O4–BaTiO3) for non-invasive neuromodulation.” Journal of Clinical and Translational Science (2020), 4(S1), 11-11. doi:10.1017/cts.2020.78
• Nguyen, T.; Walerstein, J.; Haider Al-Jaboori, M.; Xiong, W.; Jin, X. “Changes in ionotropic glutamate receptor functions underlies loss of activities of motor cortex after concussive type mild traumatic brain injury (mTBI).” Journal of Neurotrauma (2020).