18189-Nguyen, Tyler

Tyler Nguyen, PhD

Assistant Research Professor of Anesthesia

Email
ptnguyen@iu.edu
Phone
317-278-5840
Address
FH 203
ANES
IN
Indianapolis, IN
PubMed:

Bio

Tyler Nguyen M.S., Ph.D. is a neuroscientist with expertise in translational pain research spanning both preclinical and clinical domains. He received a B.S. in Chemistry and Applied Mathematics from Purdue University, an M.S. in Anatomy and Cellular Biology and a Ph.D. in Medical Neuroscience from Indiana University School of Medicine, followed by postdoctoral training at IU School of Medicine. He currently serves as a Research Assistant Professor in the Department of Anesthesia at Indiana University School of Medicine and as a faculty scientist at the Richard L. Roudebush VA Medical Center.

Dr. Nguyen’s research focuses on central nervous system plasticity and neuroinflammatory mechanisms that contribute to the development and maintenance of chronic pain. His work encompasses many different painful disorder ranging from traumatic brain injury-related persistent headaches, bone fracture pain, chemotherapy-induced peripheral neuropathy (CIPN), and interstitial cystitis/bladder pain syndrome (IC/BPS).

By integrating mechanistic studies in preclinical models with clinical investigations, he examines the cellular and molecular pathways that drive the transition from acute injury to chronic pain. His research aims to identify novel therapeutic targets and develop mechanism-based interventions to improve pain management and patient outcomes.

Grounded in translational science and interdisciplinary collaboration, his work seeks to accelerate the translation of fundamental discoveries into innovative and more effective pain therapies.

Key Publications

  • Nguyen, T.; Naugle, K.; Fletcher M.; Arellano H.; Leslie K.; Bahdanovich A.; Barger M.; Hill L.; Natoli R.; White F. “The prevalence of neuropathic pain pathophysiology associated with ankle fracture: A study protocol” Plos One. 2025

  • Yang, H.; Nguyen, T.; White, F.; Naugle, K.; Wu, Y. “White matter microstructural changes in post-traumatic headache: a diffusion tensor imaging (DTI) study.” Neuroimage Clinical. 2025.

  • Talley,S*; Nguyen, T*; Van, Ye Le et al. Characterization of age-associated inflammasome activation reveals tissue specific differences in transcriptional and post-translational inflammatory responses. Immun Ageing (2024), 21(1).

  • El Jammal R.,; Tfaily A.; Cochran AG.; Nguyen T.; Miller D.; El Ayoubi N.; Soluoku T.; White FA; Obeid M. “The long-term effects of limbic non-convulsive status epilepticus in peri-adolescent rats.” Epilepsy Behavior. 2024; 161:110086. PMID: 39476704

  • Nguyen, T.; Nguyen, N.; Cochran, A.; Smith, J.; Al-Juboori, M.; Brumett, A.; Saxena, S.; Talley, S.; Campbell, E.; Obukhov, A.; White, F. "Repeated closed-head mild traumatic brain injury induced inflammation is associated with nociceptive sensitization." Journal of Neuroinflammation (2023), 20 (196).

  • Smith, J.; Nguyen, T.; Davis, B.; Juboori, M.; White, F. “Repeated Mild Traumatic Brain Injury in Mice Elicits Long Term Innate Immune Cell Alterations in Blood, Spleen, and Brain.” Frontiers in Neuroscience. 2023.
  • Naugle K.; Nguyen, T.; Smith, J.; Saxe J.; White F.A. “Racial differences in head pain and other pain-related outcomes following mild traumatic brain injury.” Journal of Neurotrauma. 2022. DOI: 1089/neu.2022.0415.
  • Naugle, K.; Corrona, S.; Smith, J.; Nguyen, T.; Saxe, J.; White, F.A. “Physical activity behavior in the first month after mild traumatic brain injury is associated with physiological psychological risk factors for chronic pain.” Pain Reports (2021), 6(4): e969.
  • Wu, W.*; Nguyen, T.*; Ordaz, J.; Zhang, Y.; Liu, N.; Hu, X.; Ping, X.; Wu, X.; Liu, Y.; Qu, W.; Gao, S.; Shields, C.; Jin, X.; Xu, X. “Bilateral activity stimulation of motor cortex promotes forelimb recovery after spinal cord injury.” Journal of Clinical Investigation (2022), 7(12): e158150.
  • Zhang E.; Abdel-Mottaleb M.; Nguyen, T.; Jin, X.; Noga, B.; Ganzer, P.; Khizroev, S. “Magnetic-field-synchronized wireless activation of action potentials by magnetoelectric nanoparticles.” SSRN Journal. 2022. DOI: 10.2139/ssrn.4167458
  • Nguyen, T.; Gao, J.; Wang, P.; Nagesetti, A.; Andrews, P.; Masood, S.; Vriesman, Z.; Liang, P.; Khizroev, S.; Jin, X. “In vivo wireless brain stimulation via non-invasive and targeted delivery of magnetoelectric nanoparticles.” Neurotherapeutics. 18:2091-2106. (2021).
  • Nguyen, T.; Vriesman, Z.; Andrews, P.; Masood S.; Khizroev S.; Jin, X. “Magneto-electric nanoparticles (MENs) cobalt ferrite-barrium titanate (CoFe2O4–BaTiO3) for non-invasive neuromodulation.” Journal of Clinical and Translational Science (2020), 4(S1), 11-11. doi:10.1017/cts.2020.78
  • Nguyen, T.; Walerstein, J.; Haider Al-Jaboori, M.; Xiong, W.; Jin, X. “Changes in ionotropic glutamate receptor functions underlies loss of activities of motor cortex after concussive type mild traumatic brain injury (mTBI).” Journal of Neurotrauma (2020).

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