Lindsey D. Mayo, PhD
Associate Professor of Pediatrics
Adjunct Associate Professor of Biochemistry & Molecular Biology
- Phone
- (317) 278-3173
- Address
-
R4-W119
PNEB
IN
Indianapolis, IN - PubMed:
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Bio
Dr. Mayo attended Indiana State University on an athletic scholarship and obtained his B.S. in 1992 in Life Sciences. He went on to earn his Ph.D. from Wright State University in Biomedical Science in 1997. His research focus was in Biochemistry and Molecular Biology, focused on the regulation of Mdm2 oncogene.
From 1998-2003, Dr. Mayo did post-doctoral work at Indiana Unversity School of Medicine in the Walther Oncology Center and the Department of Microbiology and Immunology under the direction of Dr. David Donner. There, he made several seminal discoveries related to angiogenesis, NFkB, Akt signaling pathways, and p53-PTEN pathway.
In 2003 Dr. Mayo joined the Faculty at Case Western Reserve University, School of Medicine, in the Department of Radiation Oncology, Case Comprehensive Cancer Center as an Assistant Professor. He continued work on Mdm2 and PTEN.
In 2007, he joined the Department of Pediatrics, Herman B Wells Center for Pediatric Research and Biochemistry and Molecular Biology at IU. From 2009-2013 he was the director of the IU Simon Cancer Center summer research program for underrepresented minorities, which provided research opportunities for high school and college students. Dr. Mayo has trained numerous students (undergraduate, pre-doc, and post-docs and currently serves as a mentor in the I3 faculty mentoring program at IUSM and the Lift program at IUPUI. He currently serves on numerous committees at the university and school levels. He also serves on study sections nationally (NIH, DOD, state departments of health, and foundations) and internationally. He has continued to make novel discoveries in the area of Mdm2, p53, and PTEN related to the regulation of their respective activity and how that relates to the tumor microenvironment and tumor resistance.
| Year | Degree | Institution |
|---|---|---|
| 1997 | PhD | Wright State University |
| 1992 | BS | Indiana State University |
Current Research Interests: Mdm2 was initially described as an oncogene through its ability to transform cells. Clinically, Mdm2 is not detected in normal tissue but is detectable in 40-80% of various types of late stage cancers (adult and children). It remains unclear whether there are specific transcription factors that are necessary to elevate mdm2 gene expression in response to growth factors and cytokines, which are highly elevated in the tumor microenvironment. In addition, there are major voids in our understanding of how Mdm2 is regulated at the post-translational level to regulate proteins in tumor cells to promote metastasis in response to the growth factors and cytokines in the tumor microenvironment.
Understanding how tumor suppressor and oncogenes become altered to promote tumor metastasize and become resistant to conventional therapy.
Desc: Trustee Teaching Award
Scope: University
Date: 2013-05-01
Desc: Scholar Award
Scope: National
Date: 2004-01-01
Desc: Scholar-in-Traning Award
Scope: National
Date: 2003-04-10
Desc: Scholar-in-Traning Award
Scope: National
Date: 2002-02-13